发明授权
- 专利标题： Protein D-an IgD binding protein of Haemophilus influenzae
- 专利标题（中）： 流感嗜血杆菌蛋白D-IgD结合蛋白
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申请号： US747381申请日： 1996-11-12
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公开(公告)号： US5989828A公开(公告)日： 1999-11-23
- 发明人: Arne Forsgren
- 申请人： Arne Forsgren
- 专利权人： Forsgren; Arne
- 当前专利权人： Forsgren; Arne
- 优先权： SEX9001949 19900531
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K38/00 ; A61K39/102 ; A61P31/04 ; C07K14/005 ; C07K14/195 ; C07K14/285 ; C07K14/41 ; C07K14/705 ; C07K16/00 ; C07K16/12 ; C07K19/00 ; C12N1/21 ; C12N5/10 ; C12N15/02 ; C12N15/09 ; C12N15/31 ; C12P21/00 ; C12P21/08 ; C12R1/19 ; C12R1/21 ; C12R1/91 ; G01N33/53 ; G01N33/569 ; G01N33/577 ; C07K1/00 ; C12Q1/70 ; H01R31/08
摘要：
A novel surface exposed protein of Haemophilus influenzae or related Haemophilus species is described. The protein named protein D is an Ig receptor for human IgD and has an apparent molecular weight of 42,000. Protein D can be detected in all of 116 encapsulated and non-encapsulated isolates of H. influenzae studied. The protein from all strains shows in addition to the same apparent molecular weight immunogenic similarities since protein D from all strains interacts with three different mouse monoclonal antibodies and monoclonal human IgD. A method for purification of protein D is described. Cloning of the protein D gene from H. influenzae in E. coli is described as well as the nucleotide sequence and the deduced amino acid sequence.
公开/授权文献
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