利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

27 条记录 (耗时 0.023 秒)

    Novel surface explosed immunoglobulin d-binding protein from foraxella catarrhalis
    3.
    发明申请
    Novel surface explosed immunoglobulin d-binding protein from foraxella catarrhalis 失效
    来自卡他莫拉菌的新型表面爆炸免疫球蛋白d结合蛋白

    公开(公告)号：US20050027104A1

    公开(公告)日：2005-02-03

    申请号：US10480456

    申请日：2002-07-01

    申请人： Arne Forsgren ,  Kristian Riesbeck ,  Hakan Jansson

    发明人： Arne Forsgren ,  Kristian Riesbeck ,  Hakan Jansson

    IPC分类号： G01N33/53 ,  A61K35/14 ,  A61K39/00 ,  A61P37/06 ,  C07K1/22 ,  C07K14/195 ,  C07K14/21 ,  C07K16/12 ,  C07K19/00 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N7/00 ,  C12N15/09 ,  C12N15/31 ,  C12P21/02 ,  C07K1/00 ,  C07K14/00 ,  C07K17/00

    CPC分类号： C07K14/212 ,  A61K39/00 ,  C07K2319/00

    摘要： The present invention relates to a surface exposed protein, which can be detected in Moraxella catarrhalis, having an amino acid sequence as described in SEQ ID NO 1, an apparent molecular weight of 200 kDa and a capacity of selectively binding membrane bound or soluble IgD, to an immunogenic or IgD-binding fragment of said surface exposed protein, and to an immunogenic and adhesive fragment of said surface exposed protein. DNA segments, vaccines, plasmids and phages, non human hosts, recombinant DNA molecules and plants, fusion proteins and polypeptides and fusion products are also described. A method of detecting IgD, a method of separating IgD, a method of isolation of a surface exposed protein of Moraxella catarrhalis and a method for treatment of an autoimmune disease are also disclosed.

    摘要翻译： 本发明涉及可以在卡他莫拉菌中检测到的表面暴露蛋白质，其具有如SEQ ID NO：1所示的氨基酸序列，表观分子量为200kDa，选择性结合膜结合或可溶性IgD的能力， 涉及所述表面暴露蛋白的免疫原性或IgD结合片段，以及所述表面暴露蛋白的免疫原性和粘合性片段。 还描述了DNA片段，疫苗，质粒和噬菌体，非人宿主，重组DNA分子和植物，融合蛋白和多肽和融合产物。 还公开了检测IgD的方法，分离IgD的方法，分离莫拉氏卡他莫拉菌的表面暴露蛋白的方法和治疗自身免疫性疾病的方法。

    NOVEL SURFACE EXPOSED IMMUNOGLOBULIN D-BINDING PROTEIN FROM FORAXELLA CATARRHALIS
    6.
    发明申请
    NOVEL SURFACE EXPOSED IMMUNOGLOBULIN D-BINDING PROTEIN FROM FORAXELLA CATARRHALIS 失效
    新型表面暴露于免疫球蛋白D-BINDING蛋白

    公开(公告)号：US20100098729A1

    公开(公告)日：2010-04-22

    申请号：US12124404

    申请日：2008-05-21

    申请人： Arne Forsgren ,  Kristian Riesbeck ,  Håkan Jansson

    发明人： Arne Forsgren ,  Kristian Riesbeck ,  Håkan Jansson

    IPC分类号： A61K39/02 ,  C07K14/00 ,  A61P37/04 ,  G01N33/68

    CPC分类号： C07K14/212 ,  A61K39/00 ,  C07K2319/00

    摘要： The present invention relates to a surface exposed protein, which can be detected in Moraxella catarrhalis, having an amino acid sequence as described in SEQ ID NO: 1, an apparent molecular weight of 200 kDa and a capacity of selectively binding membrane bound or soluble IgD, to an immunogenic or IgD-binding fragment of said surface exposed protein, and to an immunogenic and adhesive fragment of said surface exposed protein. DNA segments, vaccines, plasmids and phages, non human hosts, recombinant DNA molecules and plants, fusion proteins and polypeptides and fusion products are also described. A method of detecting IgD, a method of separating IgD, a method of isolation of a surface exposed protein of Moraxella catarrhalis and a method for treatment of an autoimmune disease are also disclosed.

    摘要翻译： 本发明涉及可以在卡他莫拉菌中检测到的表面暴露蛋白，其具有如SEQ ID NO：1所示的氨基酸序列，表观分子量为200kDa，以及选择性结合膜结合或可溶性IgD的能力 涉及所述表面暴露蛋白的免疫原性或IgD结合片段，以及所述表面暴露蛋白的免疫原性和粘合性片段。 还描述了DNA片段，疫苗，质粒和噬菌体，非人宿主，重组DNA分子和植物，融合蛋白和多肽和融合产物。 还公开了检测IgD的方法，分离IgD的方法，分离莫拉氏卡他莫拉菌的表面暴露蛋白的方法和治疗自身免疫性疾病的方法。

    Methods of producing recombinant protein D
    7.
    发明授权
    Methods of producing recombinant protein D 失效
    重组蛋白D的制备方法

    公开(公告)号：US07666621B2

    公开(公告)日：2010-02-23

    申请号：US11521598

    申请日：2006-09-15

    申请人： Arne Forsgren

    发明人： Arne Forsgren

    IPC分类号： C12P21/06

    CPC分类号： A61K39/102 ,  A61K38/00 ,  A61K39/00 ,  C07K14/285 ,  C07K16/1242 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/705 ,  Y10T436/116664

    摘要： A novel surface exposed protein of Haemophilus influenzae or related Haemophilus species is described. The protein named protein D is an Ig receptor for human IgD and has an apparent molecular weight of 42,000. Protein D can be detected in all of 116 encapsulated and non-encapsulated isolates of H. influenzae studied. The protein from all strains shows in addition to the same apparent molecular weight immunogenic similarities since protein D from all strains interacts with three different mouse monoclonal antibodies and monoclonal human IgD. A method for purification of protein D is described. Cloning of the protein D gene from H. influenzae in E. coli is described as well as the nucleotide sequence and the deduced amino acid sequence.

    摘要翻译： 描述了流感嗜血杆菌或相关嗜血杆菌物种的新型表面暴露蛋白。 称为蛋白D的蛋白质是人IgD的Ig受体，其表观分子量为42,000。 蛋白D可以在所研究的流感嗜血杆菌的所有116个包封和非包囊的分离物中检测到。 来自所有菌株的蛋白质除了具有相同的表观分子量的免疫原性相似性之外还显示出，因为来自所有菌株的蛋白质D与三种不同的小鼠单克隆抗体和单克隆人IgD相互作用。 描述了蛋白D的纯化方法。 描述大肠杆菌中流感嗜血杆菌蛋白D基因的克隆以及核苷酸序列和推导的氨基酸序列。

    Protein D - an IgD-binding protein of Haemophilus influenzae
    8.
    发明申请
    Protein D - an IgD-binding protein of Haemophilus influenzae 失效
    蛋白D - 流感嗜血杆菌的IgD结合蛋白

    公开(公告)号：US20070071774A1

    公开(公告)日：2007-03-29

    申请号：US11521598

    申请日：2006-09-15

    申请人： Arne Forsgren

    发明人： Arne Forsgren

    IPC分类号： A61K39/102 ,  C07H21/04 ,  C12N15/74 ,  C12N1/21 ,  C07K14/195

    CPC分类号： A61K39/102 ,  A61K38/00 ,  A61K39/00 ,  C07K14/285 ,  C07K16/1242 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/705 ,  Y10T436/116664

    摘要： A novel surface exposed protein of Haemophilus influenzae or related Haemophilus species is described. The protein named protein D is an Ig receptor for human IgD and has an apparent molecular weight of 42,000. Protein D can be detected in all of 116 encapsulated and non-encapsulated isolates of H. influenzae studied. The protein from all strains shows in addition to the same apparent molecular weight immunogenic similarities since protein D from all strains interacts with three different mouse monoclonal antibodies and monoclonal human IgD. A method for purification of protein D is described. Cloning of the protein D gene from H. influenzae in E. coli is described as well as the nucleotide sequence and the deduced amino acid sequence.

    摘要翻译： 描述了流感嗜血杆菌或相关嗜血杆菌物种的新型表面暴露蛋白。 称为蛋白D的蛋白质是人IgD的Ig受体，其表观分子量为42,000。 蛋白D可以在所研究的流感嗜血杆菌的所有116个包封和非包囊的分离物中检测到。 来自所有菌株的蛋白质除了具有相同的表观分子量的免疫原性相似性之外还显示出，因为来自所有菌株的蛋白质D与三种不同的小鼠单克隆抗体和单克隆人IgD相互作用。 描述了蛋白D的纯化方法。 描述大肠杆菌中流感嗜血杆菌蛋白D基因的克隆以及核苷酸序列和推导的氨基酸序列。

    Surface exposed Haemophilus influenzae protein (protein E; pE)
    9.
    发明授权
    Surface exposed Haemophilus influenzae protein (protein E; pE) 有权

    公开(公告)号：US09744225B2

    公开(公告)日：2017-08-29

    申请号：US14929011

    申请日：2015-10-30

    申请人： ARNE FORSGREN et al. ,  Olle Forsgren

    发明人： Arne Forsgren ,  Kristian Riesbeck

    IPC分类号： A61K39/102 ,  C07K14/285 ,  A61K39/00

    CPC分类号： A61K39/102 ,  A61K39/00 ,  C07K14/285

    摘要： The present invention relates to a surface exposed protein (protein E; pE), a virulence factor, which can be detected in Haemophilus influenzae, having an amino acid sequence as described in SEQ ID NO 1, an immunogenic fragment of said surface exposed protein, and a recombinant immunogenic protein (pE(A)) or truncated variants thereof based on said surface exposed protein. Nucleic acid sequences, vaccines, plasmids and phages, non human hosts, recombinant nucleic acid sequences, fusion proteins and fusion products are also described. A method of producing the said protein or truncated fragments thereof recombinantly is also disclosed.

    Surface exposed Haemophilus influenzae protein (protein E; pE)
    10.
    发明授权
    Surface exposed Haemophilus influenzae protein (protein E; pE) 有权
    表面暴露的流感嗜血杆菌蛋白（蛋白E; pE）

    公开(公告)号：US08617565B2

    公开(公告)日：2013-12-31

    申请号：US12161040

    申请日：2007-01-17

    申请人： Arne Forsgren ,  Kristian Riesbeck

    发明人： Arne Forsgren ,  Kristian Riesbeck

    IPC分类号： A61K39/02 ,  A61K48/00 ,  C12Q1/68 ,  C12P21/06 ,  C07K14/235 ,  C12N15/74

    CPC分类号： A61K39/102 ,  A61K39/00 ,  C07K14/285

    摘要： The present invention relates to a surface exposed protein (protein E; pE), a virulence factor, which can be detected in Haemophilus influenzae, having an amino acid sequence as described in SEQ ID NO 1, an immunogenic fragment of said surface exposed protein, and a recombinant immunogenic protein (pE (A)) or truncated variants thereof based on said surface exposed protein. Nucleic acid sequences, vaccines, plasmids and phages, non human hosts, recombinant nucleic acid sequences, fusion proteins and fusion products are also described. A method of producing the said protein or truncated fragments thereof recombinantly is also disclosed.

    摘要翻译： 本发明涉及可以在流感嗜血杆菌中检测的具有SEQ ID NO：1所示氨基酸序列的表面暴露蛋白质（蛋白质E; pE），所述蛋白质是能够检测到的表达暴露蛋白质的免疫原性片段的毒力因子， 和基于所述表面暴露蛋白的重组免疫原性蛋白（pE（A））或其截短的变体。 还描述了核酸序列，疫苗，质粒和噬菌体，非人宿主，重组核酸序列，融合蛋白和融合产物。 还公开了重组产生所述蛋白质或其截短片段的方法。