Invention Grant
US6015572A Implantable device containing GDNF secreting cells for treating nerve
damage and methods of use
失效
含有GDNF分泌细胞用于治疗神经损伤的植入式装置和使用方法
- Patent Title: Implantable device containing GDNF secreting cells for treating nerve damage and methods of use
- Patent Title (中): 含有GDNF分泌细胞用于治疗神经损伤的植入式装置和使用方法
-
Application No.: US453176Application Date: 1995-05-30
-
Publication No.: US6015572APublication Date: 2000-01-18
- Inventor: Leu-Fen H. Lin , Franklin D. Collins , Daniel H. Doherty , Jack Lile , Susan Bektesh
- Applicant: Leu-Fen H. Lin , Franklin D. Collins , Daniel H. Doherty , Jack Lile , Susan Bektesh
- Applicant Address: CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: CA Thousand Oaks
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K9/00 ; A61K9/22 ; A61K31/00 ; A61K39/395 ; A61M37/00 ; A61P25/00 ; A61P25/16 ; A61P25/26 ; A61P25/28 ; C07H15/12 ; C07K20060101 ; C07K1/20 ; C07K1/22 ; C07K14/47 ; C07K14/475 ; C07K14/52 ; C07K16/00 ; C07K16/24 ; C12N20060101 ; C12N1/21 ; C12N1/22 ; C12N5/02 ; C12N5/06 ; C12N5/08 ; C12N5/10 ; C12N15/09 ; C12N15/12 ; C12P21/02 ; C12P21/06 ; C12P21/08 ; C12R1/19 ; C12R1/91 ; A61F2/00 ; C12N11/04
Abstract:
A novel neurotrophic factor referred to as glial cell line-derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth medium of B49 glioblastoma cells. Rat and human genes encoding GDNF have been cloned and sequenced. A gene encoding GDNF has been subcloned into a vector, and the vector has been used to transform a host cell in order to produce biologically active GDNF in a recombinant DNA process. An implantable device containing recombinant GDNF secreting cells encapsulated in a semipermeable membrane may be used to treat nerve damage in patients suffering from disorders such as Parkinson's disease.
Public/Granted literature
- US4634475A Deep-drawable aluminum sheet or strip and method of making same Public/Granted day:1987-01-06
Information query
IPC分类:
