Invention Grant
US06913909B2 Nucleotide sequences coding for the thrE gene and process for the enzymatic production of L-threonine using coryneform bacteria
失效
编码thrE基因的核苷酸序列和使用棒状细菌酶促生产L-苏氨酸的方法
- Patent Title: Nucleotide sequences coding for the thrE gene and process for the enzymatic production of L-threonine using coryneform bacteria
- Patent Title (中): 编码thrE基因的核苷酸序列和使用棒状细菌酶促生产L-苏氨酸的方法
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Application No.: US09963521Application Date: 2001-09-27
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Publication No.: US06913909B2Publication Date: 2005-07-05
- Inventor: Petra Ziegler , Lothar Eggeling , Hermann Sahm , Georg Thierbach
- Applicant: Petra Ziegler , Lothar Eggeling , Hermann Sahm , Georg Thierbach
- Applicant Address: DE Dusseldorf
- Assignee: Degussa AG
- Current Assignee: Degussa AG
- Current Assignee Address: DE Dusseldorf
- Agency: Pillsbury Winthrop Shaw Pittman LLP
- Priority: DE19941478 19990901
- Main IPC: C12N15/09
- IPC: C12N15/09 ; C07K14/34 ; C12N1/21 ; C12N15/01 ; C12N15/31 ; C12N15/77 ; C12P13/08 ; C12R1/15 ; C12N1/20 ; C12N15/00 ; C12P21/06 ; C12Q1/48
Abstract:
The invention relates to preferably recombinant DNA derived from Corynebacterium and replicable in coryneform microorganisms, which contains at least one nucleotide sequence that codes for the thrE gene, and a process for the production of L-threonine, which is characterised in that the following steps are carried out: a) Fermentation of microorganisms in which at least the thrE gene is amplified (overexpressed), optionally in combination with further genes, b) Enrichment of the L-threonine in the medium or in the cells of the microorganisms, and c) Isolation of the L-threonine.
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