- 专利标题： Hybrid hepatocyte growth factor gene having high expression efficiency of two heterotypes of hepatocyte growth factor
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申请号： US10944277申请日： 2004-09-20
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公开(公告)号： US07812146B2公开(公告)日： 2010-10-12
- 发明人: Jong-Mook Kim , Woong Hahn , Eun-Jin Park
- 申请人： Jong-Mook Kim , Woong Hahn , Eun-Jin Park
- 申请人地址： KR Seoul
- 专利权人： ViroMed Co., Ltd.
- 当前专利权人： ViroMed Co., Ltd.
- 当前专利权人地址： KR Seoul
- 代理机构： Sterne, Kessler, Goldstein & Fox P.L.L.C.
- 优先权： KR10-2002-0015074 20020320
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; C12N15/63 ; C12N15/85 ; C12N15/86 ; C12N1/20 ; C12N1/19 ; C12N15/00 ; A61K48/00 ; C12P21/00
摘要：
The present invention relates to a hybrid Hepatocyte Growth Factor (HGF) gene which is prepared by inserting an inherent or foreign intron between exons 4 and 5 in HGF cDNA, which has a base sequence of SEQ ID NO: 2. The gene has high expression efficiency and simultaneously expresses two heterotypes of HGF and dHGF (deleted variant HGF). Further the gene may be used for treating or preventing ischemic or liver diseases.
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