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    Hybrid Hepatocyte Growth Factor Gene Having High Expression Efficiency of Two Heterotypes of Hepatocyte Growth Factor
    1.
    发明申请
    Hybrid Hepatocyte Growth Factor Gene Having High Expression Efficiency of Two Heterotypes of Hepatocyte Growth Factor 有权
    具有两种肝细胞生长因子异型表达效率的混合型肝细胞生长因子基因

    公开(公告)号：US20100105878A1

    公开(公告)日：2010-04-29

    申请号：US12650860

    申请日：2009-12-31

    申请人： Jong-Mook Kim ,  Woong Hahn ,  Eun-Jin Park

    发明人： Jong-Mook Kim ,  Woong Hahn ,  Eun-Jin Park

    IPC分类号： C07K14/475 ,  C12N5/02 ,  C12N1/20 ,  C12N1/19

    CPC分类号： C07K14/4753

    摘要： The present invention relates to a hybrid Hepatocyte Growth Factor (HGF) gene which is prepared by inserting an inherent or foreign intron between exons 4 and 5 in HGF cDNA, which has a base sequence of SEQ ID NO: 2. The gene has high expression efficiency and simultaneously expresses two heterotypes of HGF and dHGF (deleted variant HGF). Further the gene may be used for treating or preventing ischemic or liver diseases.

    摘要翻译： 本发明涉及通过在具有SEQ ID NO：2的碱基序列的HGF cDNA中插入外显子4和5之间的固有或外来内含子而制备的混合肝细胞生长因子（HGF）基因。该基因具有高表达 并且同时表达HGF和dHGF（缺失变体HGF）的两种异型。 此外，该基因可用于治疗或预防缺血性或肝脏疾病。

    Compositions for gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof
    4.
    发明申请
    Compositions for gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof 失效
    用于类风湿性关节炎基因治疗的组合物，包括编码抗血管生成蛋白质的基因或其部分

    公开(公告)号：US20050277603A1

    公开(公告)日：2005-12-15

    申请号：US10220824

    申请日：2002-01-03

    申请人： Jong-Mook Kim ,  Seong-Hyun Ho ,  Eun-Jin Park ,  Sunyoung Kim

    发明人： Jong-Mook Kim ,  Seong-Hyun Ho ,  Eun-Jin Park ,  Sunyoung Kim

    IPC分类号： C12N15/09 ,  A61K35/12 ,  A61K35/76 ,  A61K38/00 ,  A61K38/19 ,  A61K38/22 ,  A61K38/39 ,  A61K38/48 ,  A61K48/00 ,  A61P29/00 ,  A61P43/00 ,  C07K14/47 ,  C12N15/867

    CPC分类号： A61K48/005 ,  A01K2267/0325 ,  A61K35/33 ,  A61K38/195 ,  A61K38/39 ,  A61K38/484 ,  A61K48/00 ,  C07K2319/02 ,  C12N15/86 ,  C12N2740/13043

    摘要： The present invention relates to the compositions for a gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof. More specifically, the present invention provides a gene therapy of rheumatoid arthritis by preparing a recombinant vector that expresses a gene encoding an anti-angiogenic protein such as angiostatin or parts thereof, and transplanting the recombinant vector or a cell that is transfected or transduced with the recombinant vector into the affected area of a patient, and also provides the compositions for the gene therapy. The compositions for the gene therapy according to the present invention can be used effectively for the treatment of rheumatoid arthritis, for which effective treating methods have not been developed until now, by providing the anti-angiogenic proteins into the knee of a patient continuously to prevent the synovial tissue hyperplasia and the resulting inflammation.

    摘要翻译： 本发明涉及用于类风湿性关节炎基因治疗的组合物，包括编码抗血管生成蛋白质的基因或其部分。 更具体地，本发明通过制备表达编码抗血管生成蛋白质的基因的重组载体，例如血管抑素或其部分，提供类风湿性关节炎的基因治疗，并移植重组载体或转染或转导的细胞 重组载体进入患者的受影响区域，并且还提供用于基因治疗的组合物。 根据本发明的基因治疗组合物可以有效地用于治疗类风湿性关节炎，通过将抗血管生成蛋白质连续地提供给患者的膝盖以防止其发生，迄今尚未开发出有效的治疗方法 滑膜组织增生和由此引起的炎症。

    Compositions for gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof
    5.
    发明授权
    Compositions for gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof 失效
    用于类风湿性关节炎基因治疗的组合物，包括编码抗血管生成蛋白质的基因或其部分

    公开(公告)号：US07175840B2

    公开(公告)日：2007-02-13

    申请号：US10220824

    申请日：2002-01-03

    申请人： Jong-Mook Kim ,  Seong-Hyun Ho ,  Eun-Jin Park ,  Sunyoung Kim

    发明人： Jong-Mook Kim ,  Seong-Hyun Ho ,  Eun-Jin Park ,  Sunyoung Kim

    IPC分类号： A01N63/00 ,  A01N65/00 ,  A61K48/00 ,  A01N43/04 ,  A61K31/715 ,  C12N15/00 ,  C12N15/09 ,  C12N15/63 ,  C12N15/70 ,  C12N15/74

    CPC分类号： A61K48/005 ,  A01K2267/0325 ,  A61K35/33 ,  A61K38/195 ,  A61K38/39 ,  A61K38/484 ,  A61K48/00 ,  C07K2319/02 ,  C12N15/86 ,  C12N2740/13043

    摘要： The present invention relates to the compositions for a gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof. More specifically, the present invention provides a gene therapy of rheumatoid arthritis by preparing a recombinant vector that expresses a gene encoding an anti-angiogenic protein such as angiostatin or parts thereof, and transplanting the recombinant vector or a cell that is transfected or transduced with the recombinant vector into the affected area of a patient, and also provides the compositions for the gene therapy. The compositions for the gene therapy according to the present invention can be used effectively for the treatment of rheumatoid arthritis, for which effective treating methods have not been developed until now, by providing the anti-angiogenic proteins into the knee of a patient continuously to prevent the synovial tissue hyperplasia and the resulting inflammation.

    摘要翻译： 本发明涉及用于类风湿性关节炎基因治疗的组合物，包括编码抗血管生成蛋白质的基因或其部分。 更具体地，本发明通过制备表达编码抗血管生成蛋白质的基因的重组载体，例如血管抑素或其部分，提供类风湿性关节炎的基因治疗，并移植重组载体或转染或转导的细胞 重组载体进入患者的受影响区域，并且还提供用于基因治疗的组合物。 根据本发明的基因治疗组合物可以有效地用于治疗类风湿性关节炎，通过将抗血管生成蛋白质连续地提供给患者的膝盖以防止其发生，迄今尚未开发出有效的治疗方法 滑膜组织增生和由此引起的炎症。

    Compositions for gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof
    6.
    发明申请
    Compositions for gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof 审中-公开
    用于类风湿性关节炎基因治疗的组合物，包括编码抗血管生成蛋白质的基因或其部分

    公开(公告)号：US20060198826A1

    公开(公告)日：2006-09-07

    申请号：US11431663

    申请日：2006-05-11

    申请人： Jong-Mook Kim ,  Seong-Hyun Ho ,  Eun-Jin Park ,  Sunyoung Kim

    发明人： Jong-Mook Kim ,  Seong-Hyun Ho ,  Eun-Jin Park ,  Sunyoung Kim

    IPC分类号： A61K48/00 ,  C12N15/86

    CPC分类号： A61K48/005 ,  A01K2267/0325 ,  A61K35/33 ,  A61K38/195 ,  A61K38/39 ,  A61K38/484 ,  A61K48/00 ,  C07K2319/02 ,  C12N15/86 ,  C12N2740/13043

    摘要： The present invention relates to the compositions for a gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof. More specifically, the present invention provides a gene therapy of rheumatoid arthritis by preparing a recombinant vector that expresses a gene encoding an anti-angiogenic protein such as endostatin or parts thereof, and transplanting the recombinant vector or a cell that is transfected or transduced with the recombinant vector into the affected area of a patient, and also provides the compositions for the gene therapy. The compositions for the gene therapy according to the present invention can be used effectively for the treatment of rheumatoid arthritis, for which effective treating methods have not been developed until now, by providing the anti-angiogenic proteins into the knee of a patient continuously to prevent the synovial tissue hyperplasia and the resulting inflammation.

    摘要翻译： 本发明涉及用于类风湿性关节炎基因治疗的组合物，包括编码抗血管生成蛋白质的基因或其部分。 更具体地说，本发明通过制备表达编码抗血管生成蛋白质如内皮抑素或其部分的基因的重组载体，并且将所述重组载体或转染或转导的细胞移植到所述基因治疗中来提供类风湿性关节炎的基因治疗 重组载体进入患者的受影响区域，并且还提供用于基因治疗的组合物。 根据本发明的基因治疗组合物可以有效地用于治疗类风湿性关节炎，通过将抗血管生成蛋白质连续地提供给患者的膝盖以防止其发生，迄今尚未开发出有效的治疗方法 滑膜组织增生和由此引起的炎症。

    Compositions for gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof
    7.
    发明申请
    Compositions for gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof 审中-公开
    用于类风湿性关节炎基因治疗的组合物，包括编码抗血管生成蛋白质的基因或其部分

    公开(公告)号：US20060193833A1

    公开(公告)日：2006-08-31

    申请号：US11431526

    申请日：2006-05-11

    申请人： Jong-Mook Kim ,  Seong-Hyun Ho ,  Eun-Jin Park ,  Sunyoung Kim

    发明人： Jong-Mook Kim ,  Seong-Hyun Ho ,  Eun-Jin Park ,  Sunyoung Kim

    IPC分类号： A61K48/00

    CPC分类号： A61K48/005 ,  A01K2267/0325 ,  A61K35/33 ,  A61K38/195 ,  A61K38/39 ,  A61K38/484 ,  A61K48/00 ,  C07K2319/02 ,  C12N15/86 ,  C12N2740/13043

    摘要： The present invention relates to the compositions for a gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof. More specifically, the present invention provides a gene therapy of rheumatoid arthritis by preparing a recombinant vector that expresses a gene encoding an anti-angiogenic protein such as platelet factor-4 or parts thereof, and transplanting the recombinant vector or a cell that is transfected or transduced with the recombinant vector into the affected area of a patient, and also provides the compositions for the gene therapy. The compositions for the gene therapy according to the present invention can be used effectively for the treatment of rheumatoid arthritis, for which effective treating methods have not been developed until now, by providing the anti-angiogenic proteins into the knee of a patient continuously to prevent the synovial tissue hyperplasia and the resulting inflammation.

    摘要翻译： 本发明涉及用于类风湿性关节炎基因治疗的组合物，包括编码抗血管生成蛋白质的基因或其部分。 更具体地说，本发明通过制备表达编码抗血管生成蛋白质如血小板因子-4或其部分的基因的重组载体，并且将重组载体或转染的细胞或其它细胞移植，从而提供类风湿性关节炎的基因治疗 用重组载体转导到患者的受影响区域，并提供用于基因治疗的组合物。 根据本发明的基因治疗组合物可以有效地用于治疗类风湿性关节炎，通过将抗血管生成蛋白质连续地提供给患者的膝盖以防止其发生，迄今尚未开发出有效的治疗方法 滑膜组织增生和由此引起的炎症。

    Method for operating washing machine
    8.
    发明申请
    Method for operating washing machine 审中-公开
    洗衣机操作方法

    公开(公告)号：US20090100608A1

    公开(公告)日：2009-04-23

    申请号：US12230807

    申请日：2008-09-04

    申请人： Deug-Hee Lee ,  Pyoung-Hwan Kim ,  Eun-Jin Park ,  Hyung-Yong Kim ,  Seong-Hae Jeong

    发明人： Deug-Hee Lee ,  Pyoung-Hwan Kim ,  Eun-Jin Park ,  Hyung-Yong Kim ,  Seong-Hae Jeong

    IPC分类号： D06F39/08

    CPC分类号： D06F35/006

    摘要： Disclosed is a method for operating a washing machine. The method includes a rinsing step for rinsing the laundry by supplying water after the rinsing step, the supplying of the circulation water being stopped or executed for only a certain time. Accordingly, the circulation water is not continuously supplied during the rinsing step, thus it is capable of preventing bubbles from being generated caused by continuously supplying the circulation water. Accordingly, it is capable of preventing detergent dregs from remaining on the laundry even after the rinsing step. And, it is capable of preventing large load from being applied to the washing motors due to the bubbles, thereby being capable of enhancing efficiency of the washing motors and preventing a fire due to increase of a temperature.

    摘要翻译： 公开了一种操作洗衣机的方法。 该方法包括：漂洗步骤，用于在漂洗步骤之后通过供水来洗涤衣物，仅在一定时间内供应停止或执行的循环水。 因此，在漂洗工序中不会连续地供给循环水，能够防止连续地供给循环水而产生气泡。 因此，即使在漂洗步骤之后，也能够防止洗涤剂渣残留在衣物上。 并且，能够防止由于气泡而导致的大的负荷被施加到洗涤电动机，从而能够提高洗涤电动机的效率并防止由于温度升高引起的火灾。

    Drum type washing machine having touch up function and method for touching up thereof
    9.
    发明授权
    Drum type washing machine having touch up function and method for touching up thereof 有权
    具有触摸功能的滚筒式洗衣机及其接触方法

    公开(公告)号：US09003587B2

    公开(公告)日：2015-04-14

    申请号：US12204158

    申请日：2008-09-04

    申请人： Deug-Hee Lee ,  Pyoung-Hwan Kim ,  Eun-Jin Park ,  Hyung-Yong Kim ,  Seong-Hae Jeong

    发明人： Deug-Hee Lee ,  Pyoung-Hwan Kim ,  Eun-Jin Park ,  Hyung-Yong Kim ,  Seong-Hae Jeong

    IPC分类号： D06B19/00 ,  D06F58/20 ,  D06F39/00

    CPC分类号： D06F58/203 ,  D06F39/008

    摘要： Disclosed is a drum type washing machine having a touch up function and a method for touching up thereof. The drum type washing machine having the touch up function is provided with a touch up button for removing wrinkles on laundry left in the drum type washing machine and a method for touching up. Accordingly, it is not required for a user to additionally execute rinsing and dehydrating processes, or ironing so as to remove wrinkles on the laundry, thus it is convenient. And, since it is not required to additionally execute the rinsing and dehydrating processes, it is capable of preventing unwanted consumption of water and electricity.

    摘要翻译： 公开了一种具有触摸功能的滚筒式洗衣机及其接触方法。 具有触摸功能的滚筒式洗衣机设置有用于去除滚筒式洗衣机中留下的衣物上的褶皱的触摸按钮和用于触摸的方法。 因此，用户不需要另外执行冲洗和脱水处理或熨烫以消除衣物上的皱纹，因此是方便的。 并且，由于不需要另外执行漂洗和脱水处理，因此能够防止水和电的不期望的消耗。