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36 条记录 (耗时 0.021 秒)

    HERBAL COMPOSITIONS FOR TREATING NEUROLOGICAL DISEASES AND IMPROVING MEMORY IMPAIRMENT
    1.
    发明申请
    HERBAL COMPOSITIONS FOR TREATING NEUROLOGICAL DISEASES AND IMPROVING MEMORY IMPAIRMENT 审中-公开
    用于治疗神经病变和改善记忆障碍的草本组合物

    公开(公告)号：US20140023677A1

    公开(公告)日：2014-01-23

    申请号：US14007095

    申请日：2012-03-29

    申请人： Doo Suk Lee ,  Dong Sik Kim ,  Seon Hee Kim

    发明人： Doo Suk Lee ,  Dong Sik Kim ,  Seon Hee Kim

    IPC分类号： A61K36/9066 ,  A61K45/06 ,  A61K36/8988 ,  A61K36/88 ,  A61K36/77 ,  A61K36/537

    CPC分类号： A61K36/9066 ,  A61K36/537 ,  A61K36/77 ,  A61K36/88 ,  A61K36/8988 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention relates to a composition for preventing or treating neurological diseases including an extract of Euphoria longan fruit, red sage and Gastrodia elata as an active ingredient. The composition of the present disclosure has a superior effect of inhibiting the activity of acetylcholinesterase (AChE), which hydrolyzes the neurotransmitter acetylcholine directly involved in impairment of cognitive function. In addition, the composition of the present disclosure is safe for the human body since the biologically safe extract of Euphoria longan fruit, red sage and Gastrodia elata is used as the active ingredient.

    摘要翻译： 本发明涉及一种用于预防或治疗神经系统疾病的组合物，其中包括幸福兰桂果，红鼠尾草和天麻提取物作为活性成分。 本公开的组合物具有抑制乙酰胆碱酯酶（AChE）的活性的优异效果，其水解直接参与认知功能损伤的神经递质乙酰胆碱。 此外，本公开的组合物对于人体来说是安全的，因为使用了富兰克兰龙眼水果，红鼠尾草和天麻的生物安全提取物作为活性成分。

    Lyophilized DNA formulations for enhanced expression of plasmid DNA
    3.
    发明授权
    Lyophilized DNA formulations for enhanced expression of plasmid DNA 有权
    用于增强质粒DNA表​​达的冻干DNA制剂

    公开(公告)号：US08389492B2

    公开(公告)日：2013-03-05

    申请号：US13045460

    申请日：2011-03-10

    申请人： Jong-Mook Kim ,  Sujeong Kim ,  Woong Hahn ,  WonSun Yoo

    发明人： Jong-Mook Kim ,  Sujeong Kim ,  Woong Hahn ,  WonSun Yoo

    IPC分类号： A61K31/7088

    CPC分类号： C07K14/4753

    摘要： The present invention provides for a method of treating or preventing ischemic or liver disease in a subject by administering a composition reconstituted from a lyophilized hepatocyte growth factor (HGF) DNA formulation, where the DNA formulation comprises an HGF plasmid DNA, salt and a carbohydrate. The invention further provides for a method of making such a lyophilized DNA formulation that preserves or enhances gene expression both in vitro and in vivo, thus maintaining or stimulating the biological activity of the expressed protein. The invention also provides for the DNA formulation, or the lyophilized DNA formulation according to the methods disclosed.

    摘要翻译： 本发明提供了通过施用从冻干的肝细胞生长因子（HGF）DNA制剂重组的组合物来治疗或预防受试者的缺血性或肝脏疾病的方法，其中所述DNA制剂包含HGF质粒DNA，盐和碳水化合物。 本发明进一步提供了制备这样的冻干DNA制剂的方法，其在体外和体内保留或增强基因表达，从而维持或刺激所表达的蛋白质的生物学活性。 本发明还提供了根据所公开的方法的DNA制剂或冻干的DNA制剂。

    Adenovirus producing novel cell line and the use thereof
    10.
    发明授权
    Adenovirus producing novel cell line and the use thereof 有权
    产生新型细胞系的腺病毒及其用途

    公开(公告)号：US09404090B2

    公开(公告)日：2016-08-02

    申请号：US14360195

    申请日：2012-11-22

    申请人： VIROMED CO., LTD.

    发明人： Seung Shin Yu ,  Chang-Wan Joo ,  Jin-A Chae ,  Yeon Suk Cha

    IPC分类号： C12P21/00 ,  C12N15/86 ,  C12N7/00 ,  C12N5/16 ,  C12N15/12 ,  C12N15/13 ,  C12N5/10

    CPC分类号： C12N7/00 ,  C12N15/86 ,  C12N2710/10351 ,  C12P21/00

    摘要： The invention relates to a cell line in which an expression construct is introduced into genomic DNA, the expression construct including: (a) a promoter operable in animal cells and heterologous to adenoviruses; and (b) a modified adenovirus El coding gene sequence of SEQ ID NO: 32 operatively linked to the promoter. The cell line of the invention is less likely to produce a replication competent adenovirus (RCA). The adenovirus producing cell line of the invention has a low possibility of producing RCA due to homologous recombination, when compared with conventional cell lines. Therefore, this makes it possible to regulate the required amount of virus during gene therapy using the adenovirus and prevent tissue damage and toxic effects caused by overproduction of the adenovirus. Also, the cell line of the invention shows superior adenovirus producing ability, as compared with an HEK 293 cell which is one of conventional adenovirus producing cell lines.

    摘要翻译： 本发明涉及其中将表达构建体引入基因组DNA的细胞系，该表达构建体包括：（a）可在动物细胞中可操作并且与腺病毒异源的启动子; 和（b）与启动子有效连接的SEQ ID NO：32的修饰的腺病毒E1编码基因序列。 本发明的细胞系不太可能产生复制型腺病毒（RCA）。 与常规细胞系相比，本发明的腺病毒产生细胞系与同源重组产生RCA的可能性低。 因此，这可以在使用腺病毒的基因治疗期间调节所需量的病毒，并防止由腺病毒过量产生引起的组织损伤和毒性作用。 此外，与作为常规腺病毒产生细胞系之一的HEK 293细胞相比，本发明的细胞系显示出优异的腺病毒产生能力。