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    Hybrid Hepatocyte Growth Factor Gene Having High Expression Efficiency of Two Heterotypes of Hepatocyte Growth Factor
    2.
    发明申请
    Hybrid Hepatocyte Growth Factor Gene Having High Expression Efficiency of Two Heterotypes of Hepatocyte Growth Factor 有权
    具有两种肝细胞生长因子异型表达效率的混合型肝细胞生长因子基因

    公开(公告)号：US20100105878A1

    公开(公告)日：2010-04-29

    申请号：US12650860

    申请日：2009-12-31

    申请人： Jong-Mook Kim ,  Woong Hahn ,  Eun-Jin Park

    发明人： Jong-Mook Kim ,  Woong Hahn ,  Eun-Jin Park

    IPC分类号： C07K14/475 ,  C12N5/02 ,  C12N1/20 ,  C12N1/19

    CPC分类号： C07K14/4753

    摘要： The present invention relates to a hybrid Hepatocyte Growth Factor (HGF) gene which is prepared by inserting an inherent or foreign intron between exons 4 and 5 in HGF cDNA, which has a base sequence of SEQ ID NO: 2. The gene has high expression efficiency and simultaneously expresses two heterotypes of HGF and dHGF (deleted variant HGF). Further the gene may be used for treating or preventing ischemic or liver diseases.

    摘要翻译： 本发明涉及通过在具有SEQ ID NO：2的碱基序列的HGF cDNA中插入外显子4和5之间的固有或外来内含子而制备的混合肝细胞生长因子（HGF）基因。该基因具有高表达 并且同时表达HGF和dHGF（缺失变体HGF）的两种异型。 此外，该基因可用于治疗或预防缺血性或肝脏疾病。

    Compositions for gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof
    4.
    发明申请
    Compositions for gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof 失效
    用于类风湿性关节炎基因治疗的组合物，包括编码抗血管生成蛋白质的基因或其部分

    公开(公告)号：US20050277603A1

    公开(公告)日：2005-12-15

    申请号：US10220824

    申请日：2002-01-03

    申请人： Jong-Mook Kim ,  Seong-Hyun Ho ,  Eun-Jin Park ,  Sunyoung Kim

    发明人： Jong-Mook Kim ,  Seong-Hyun Ho ,  Eun-Jin Park ,  Sunyoung Kim

    IPC分类号： C12N15/09 ,  A61K35/12 ,  A61K35/76 ,  A61K38/00 ,  A61K38/19 ,  A61K38/22 ,  A61K38/39 ,  A61K38/48 ,  A61K48/00 ,  A61P29/00 ,  A61P43/00 ,  C07K14/47 ,  C12N15/867

    CPC分类号： A61K48/005 ,  A01K2267/0325 ,  A61K35/33 ,  A61K38/195 ,  A61K38/39 ,  A61K38/484 ,  A61K48/00 ,  C07K2319/02 ,  C12N15/86 ,  C12N2740/13043

    摘要： The present invention relates to the compositions for a gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof. More specifically, the present invention provides a gene therapy of rheumatoid arthritis by preparing a recombinant vector that expresses a gene encoding an anti-angiogenic protein such as angiostatin or parts thereof, and transplanting the recombinant vector or a cell that is transfected or transduced with the recombinant vector into the affected area of a patient, and also provides the compositions for the gene therapy. The compositions for the gene therapy according to the present invention can be used effectively for the treatment of rheumatoid arthritis, for which effective treating methods have not been developed until now, by providing the anti-angiogenic proteins into the knee of a patient continuously to prevent the synovial tissue hyperplasia and the resulting inflammation.

    摘要翻译： 本发明涉及用于类风湿性关节炎基因治疗的组合物，包括编码抗血管生成蛋白质的基因或其部分。 更具体地，本发明通过制备表达编码抗血管生成蛋白质的基因的重组载体，例如血管抑素或其部分，提供类风湿性关节炎的基因治疗，并移植重组载体或转染或转导的细胞 重组载体进入患者的受影响区域，并且还提供用于基因治疗的组合物。 根据本发明的基因治疗组合物可以有效地用于治疗类风湿性关节炎，通过将抗血管生成蛋白质连续地提供给患者的膝盖以防止其发生，迄今尚未开发出有效的治疗方法 滑膜组织增生和由此引起的炎症。

    Compositions for gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof
    5.
    发明授权
    Compositions for gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof 失效
    用于类风湿性关节炎基因治疗的组合物，包括编码抗血管生成蛋白质的基因或其部分

    公开(公告)号：US07175840B2

    公开(公告)日：2007-02-13

    申请号：US10220824

    申请日：2002-01-03

    申请人： Jong-Mook Kim ,  Seong-Hyun Ho ,  Eun-Jin Park ,  Sunyoung Kim

    发明人： Jong-Mook Kim ,  Seong-Hyun Ho ,  Eun-Jin Park ,  Sunyoung Kim

    IPC分类号： A01N63/00 ,  A01N65/00 ,  A61K48/00 ,  A01N43/04 ,  A61K31/715 ,  C12N15/00 ,  C12N15/09 ,  C12N15/63 ,  C12N15/70 ,  C12N15/74

    CPC分类号： A61K48/005 ,  A01K2267/0325 ,  A61K35/33 ,  A61K38/195 ,  A61K38/39 ,  A61K38/484 ,  A61K48/00 ,  C07K2319/02 ,  C12N15/86 ,  C12N2740/13043

    摘要： The present invention relates to the compositions for a gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof. More specifically, the present invention provides a gene therapy of rheumatoid arthritis by preparing a recombinant vector that expresses a gene encoding an anti-angiogenic protein such as angiostatin or parts thereof, and transplanting the recombinant vector or a cell that is transfected or transduced with the recombinant vector into the affected area of a patient, and also provides the compositions for the gene therapy. The compositions for the gene therapy according to the present invention can be used effectively for the treatment of rheumatoid arthritis, for which effective treating methods have not been developed until now, by providing the anti-angiogenic proteins into the knee of a patient continuously to prevent the synovial tissue hyperplasia and the resulting inflammation.

    摘要翻译： 本发明涉及用于类风湿性关节炎基因治疗的组合物，包括编码抗血管生成蛋白质的基因或其部分。 更具体地，本发明通过制备表达编码抗血管生成蛋白质的基因的重组载体，例如血管抑素或其部分，提供类风湿性关节炎的基因治疗，并移植重组载体或转染或转导的细胞 重组载体进入患者的受影响区域，并且还提供用于基因治疗的组合物。 根据本发明的基因治疗组合物可以有效地用于治疗类风湿性关节炎，通过将抗血管生成蛋白质连续地提供给患者的膝盖以防止其发生，迄今尚未开发出有效的治疗方法 滑膜组织增生和由此引起的炎症。

    Compositions for gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof
    6.
    发明申请
    Compositions for gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof 审中-公开
    用于类风湿性关节炎基因治疗的组合物，包括编码抗血管生成蛋白质的基因或其部分

    公开(公告)号：US20060198826A1

    公开(公告)日：2006-09-07

    申请号：US11431663

    申请日：2006-05-11

    申请人： Jong-Mook Kim ,  Seong-Hyun Ho ,  Eun-Jin Park ,  Sunyoung Kim

    发明人： Jong-Mook Kim ,  Seong-Hyun Ho ,  Eun-Jin Park ,  Sunyoung Kim

    IPC分类号： A61K48/00 ,  C12N15/86

    CPC分类号： A61K48/005 ,  A01K2267/0325 ,  A61K35/33 ,  A61K38/195 ,  A61K38/39 ,  A61K38/484 ,  A61K48/00 ,  C07K2319/02 ,  C12N15/86 ,  C12N2740/13043

    摘要： The present invention relates to the compositions for a gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof. More specifically, the present invention provides a gene therapy of rheumatoid arthritis by preparing a recombinant vector that expresses a gene encoding an anti-angiogenic protein such as endostatin or parts thereof, and transplanting the recombinant vector or a cell that is transfected or transduced with the recombinant vector into the affected area of a patient, and also provides the compositions for the gene therapy. The compositions for the gene therapy according to the present invention can be used effectively for the treatment of rheumatoid arthritis, for which effective treating methods have not been developed until now, by providing the anti-angiogenic proteins into the knee of a patient continuously to prevent the synovial tissue hyperplasia and the resulting inflammation.

    摘要翻译： 本发明涉及用于类风湿性关节炎基因治疗的组合物，包括编码抗血管生成蛋白质的基因或其部分。 更具体地说，本发明通过制备表达编码抗血管生成蛋白质如内皮抑素或其部分的基因的重组载体，并且将所述重组载体或转染或转导的细胞移植到所述基因治疗中来提供类风湿性关节炎的基因治疗 重组载体进入患者的受影响区域，并且还提供用于基因治疗的组合物。 根据本发明的基因治疗组合物可以有效地用于治疗类风湿性关节炎，通过将抗血管生成蛋白质连续地提供给患者的膝盖以防止其发生，迄今尚未开发出有效的治疗方法 滑膜组织增生和由此引起的炎症。

    Compositions for gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof
    7.
    发明申请
    Compositions for gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof 审中-公开
    用于类风湿性关节炎基因治疗的组合物，包括编码抗血管生成蛋白质的基因或其部分

    公开(公告)号：US20060193833A1

    公开(公告)日：2006-08-31

    申请号：US11431526

    申请日：2006-05-11

    申请人： Jong-Mook Kim ,  Seong-Hyun Ho ,  Eun-Jin Park ,  Sunyoung Kim

    发明人： Jong-Mook Kim ,  Seong-Hyun Ho ,  Eun-Jin Park ,  Sunyoung Kim

    IPC分类号： A61K48/00

    CPC分类号： A61K48/005 ,  A01K2267/0325 ,  A61K35/33 ,  A61K38/195 ,  A61K38/39 ,  A61K38/484 ,  A61K48/00 ,  C07K2319/02 ,  C12N15/86 ,  C12N2740/13043

    摘要： The present invention relates to the compositions for a gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof. More specifically, the present invention provides a gene therapy of rheumatoid arthritis by preparing a recombinant vector that expresses a gene encoding an anti-angiogenic protein such as platelet factor-4 or parts thereof, and transplanting the recombinant vector or a cell that is transfected or transduced with the recombinant vector into the affected area of a patient, and also provides the compositions for the gene therapy. The compositions for the gene therapy according to the present invention can be used effectively for the treatment of rheumatoid arthritis, for which effective treating methods have not been developed until now, by providing the anti-angiogenic proteins into the knee of a patient continuously to prevent the synovial tissue hyperplasia and the resulting inflammation.

    摘要翻译： 本发明涉及用于类风湿性关节炎基因治疗的组合物，包括编码抗血管生成蛋白质的基因或其部分。 更具体地说，本发明通过制备表达编码抗血管生成蛋白质如血小板因子-4或其部分的基因的重组载体，并且将重组载体或转染的细胞或其它细胞移植，从而提供类风湿性关节炎的基因治疗 用重组载体转导到患者的受影响区域，并提供用于基因治疗的组合物。 根据本发明的基因治疗组合物可以有效地用于治疗类风湿性关节炎，通过将抗血管生成蛋白质连续地提供给患者的膝盖以防止其发生，迄今尚未开发出有效的治疗方法 滑膜组织增生和由此引起的炎症。

    Lyophilized DNA formulations for enhanced expression of plasmid DNA
    9.
    发明授权
    Lyophilized DNA formulations for enhanced expression of plasmid DNA 有权
    用于增强质粒DNA表​​达的冻干DNA制剂

    公开(公告)号：US08389492B2

    公开(公告)日：2013-03-05

    申请号：US13045460

    申请日：2011-03-10

    申请人： Jong-Mook Kim ,  Sujeong Kim ,  Woong Hahn ,  WonSun Yoo

    发明人： Jong-Mook Kim ,  Sujeong Kim ,  Woong Hahn ,  WonSun Yoo

    IPC分类号： A61K31/7088

    CPC分类号： C07K14/4753

    摘要： The present invention provides for a method of treating or preventing ischemic or liver disease in a subject by administering a composition reconstituted from a lyophilized hepatocyte growth factor (HGF) DNA formulation, where the DNA formulation comprises an HGF plasmid DNA, salt and a carbohydrate. The invention further provides for a method of making such a lyophilized DNA formulation that preserves or enhances gene expression both in vitro and in vivo, thus maintaining or stimulating the biological activity of the expressed protein. The invention also provides for the DNA formulation, or the lyophilized DNA formulation according to the methods disclosed.

    摘要翻译： 本发明提供了通过施用从冻干的肝细胞生长因子（HGF）DNA制剂重组的组合物来治疗或预防受试者的缺血性或肝脏疾病的方法，其中所述DNA制剂包含HGF质粒DNA，盐和碳水化合物。 本发明进一步提供了制备这样的冻干DNA制剂的方法，其在体外和体内保留或增强基因表达，从而维持或刺激所表达的蛋白质的生物学活性。 本发明还提供了根据所公开的方法的DNA制剂或冻干的DNA制剂。