Invention Grant
US09206116B2 Process for preparing 5-biphenyl-4-amino-2-methyl pentanoic acid
有权
制备5-联苯-4-氨基-2-甲基戊酸的方法
- Patent Title: Process for preparing 5-biphenyl-4-amino-2-methyl pentanoic acid
- Patent Title (中): 制备5-联苯-4-氨基-2-甲基戊酸的方法
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Application No.: US14627542Application Date: 2015-02-20
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Publication No.: US09206116B2Publication Date: 2015-12-08
- Inventor: David Hook , Thomas Ruch , Bernard Riss , Bernhard Wietfeld , Gottfried Sedelmeier , Matthias Napp , Markus Bänziger , Steven Hawker , Lech Ciszewski , Liladhar Murlidhar Waykole
- Applicant: David Hook , Thomas Ruch , Bernard Riss , Bernhard Wietfeld , Gottfried Sedelmeier , Matthias Napp , Markus Bänziger , Steven Hawker , Lech Ciszewski , Liladhar Murlidhar Waykole
- Applicant Address: CH Basel
- Assignee: NOVARTIS AG
- Current Assignee: NOVARTIS AG
- Current Assignee Address: CH Basel
- Agent David R. Kurlandsky
- Priority: EP07100451 20070112
- Main IPC: C07C231/02
- IPC: C07C231/02 ; C07C227/16 ; C07C227/22 ; C07C227/32 ; C07C229/34 ; C07C233/47 ; C07C271/22 ; C07D207/24 ; C07D207/26 ; C07D207/267 ; C07D207/27 ; C07D207/273 ; C07D207/277 ; C07D207/40 ; C07D207/44 ; C07F7/10 ; C07C219/18 ; C07D207/12 ; C07C227/20 ; C07C231/12 ; C07C269/04 ; C07D207/404 ; C07D403/06 ; C07C231/14
Abstract:
The present invention relates to pyrrolidin-2-ones according to the formula (1), or salts thereof, wherein R1 is hydrogen or a nitrogen protecting group, methods for their preparation and their use in the preparation of NEP-inhibitors, particularly in the preparation of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof.
Public/Granted literature
- US20150166468A1 Process for Preparing 5-biphenyl-4-amino-2-methyl Pentanoic Acid Public/Granted day:2015-06-18
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