发明授权
US09234169B2 Enzymatical modification of cell glycosylation using serum albumin and divalent cations
有权
使用血清白蛋白和二价阳离子对细胞糖基化进行酶学修饰
- 专利标题： Enzymatical modification of cell glycosylation using serum albumin and divalent cations
- 专利标题（中）： 使用血清白蛋白和二价阳离子对细胞糖基化进行酶学修饰
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申请号： US13054541申请日： 2009-07-16
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公开(公告)号： US09234169B2公开(公告)日： 2016-01-12
- 发明人: Johanna Nystedt , Heidi Anderson , Leena Valmu , Jari Natunen , Tero Satomaa
- 申请人： Johanna Nystedt , Heidi Anderson , Leena Valmu , Jari Natunen , Tero Satomaa
- 申请人地址： FI Helsinki
- 专利权人： Glykos Finland
- 当前专利权人： Glykos Finland
- 当前专利权人地址： FI Helsinki
- 代理机构： Brooks Kushman P.C.
- 优先权： EP08397517 20080716
- 国际申请： PCT/FI2009/050628 WO 20090716
- 国际公布： WO2010/007214 WO 20100121
- 主分类号： C12P21/04
- IPC分类号： C12P21/04 ; C12N9/10 ; C12N5/071 ; C07H21/04 ; C12N5/00 ; C12P21/00 ; C12N5/0775 ; A61K35/12
摘要：
The invention is directed to a method and kit to control and modify the status of cells, such as human stem cells, by changing their glycosylation, in particular sialylation and fucosylation, levels in a reaction condition where culture medium reagents, such as divalent cations, are present and cells are kept non-adherent. The invention is further directed to novel stem cells, the glycosylation of which has been specifically altered.
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