发明授权
- 专利标题: Cyclopropaneamine compound
- 专利标题(中): 环丙烷胺化合物
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申请号: US14237440申请日: 2012-08-08
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公开(公告)号: US09278931B2公开(公告)日: 2016-03-08
- 发明人: Naoki Tomita , Shigeo Kajii , Douglas Robert Cary , Daisuke Tomita , Shinichi Imamura , Ken Tsuchida , Satoru Matsuda , Ryujiro Hara , Yusuke Tominari
- 申请人: Naoki Tomita , Shigeo Kajii , Douglas Robert Cary , Daisuke Tomita , Shinichi Imamura , Ken Tsuchida , Satoru Matsuda , Ryujiro Hara , Yusuke Tominari
- 申请人地址: JP Osaka
- 专利权人: Takeda Pharmaceutical Company Limited
- 当前专利权人: Takeda Pharmaceutical Company Limited
- 当前专利权人地址: JP Osaka
- 代理机构: Hamre, Schumann, Mueller & Larson, P.C.
- 优先权: JP2011-174305 20110809
- 国际申请: PCT/JP2012/070267 WO 20120808
- 国际公布: WO2013/022047 WO 20130214
- 主分类号: A61K31/167
- IPC分类号: A61K31/167 ; A61K31/435 ; A61K31/415 ; A61K31/382 ; C07D295/14 ; C07D231/14 ; C07D231/56 ; C07D231/20 ; C07D231/22 ; C07C233/80 ; C07C271/22 ; C07C235/56 ; C07C237/40 ; C07D211/98 ; A61K31/36 ; A61K31/366 ; A61K31/381 ; A61K31/40 ; A61K31/402 ; A61K31/4035 ; A61K31/404 ; A61K31/4184 ; A61K31/42 ; A61K31/421 ; A61K31/426 ; A61K31/428 ; A61K31/429 ; A61K31/433 ; A61K31/4406 ; A61K31/4409 ; A61K31/4453 ; A61K31/4468 ; A61K31/451 ; A61K31/495 ; A61K31/55 ; C07D309/14 ; C07D317/58 ; C07D223/16 ; C07D333/20 ; C07D233/61 ; C07D233/64 ; C07D405/04 ; C07D239/36 ; C07D409/04 ; C07D471/04 ; C07D261/08 ; C07D261/10 ; C07D263/32 ; C07D263/34 ; C07D207/06 ; C07D495/04 ; C07D207/337 ; C07D277/20 ; C07D277/28 ; C07D277/30 ; C07D209/08 ; C07D277/62 ; C07D209/42 ; C07D513/04 ; C07D209/46 ; C07D209/48 ; C07D285/06 ; C07D211/56 ; C07D211/58 ; C07D211/76 ; C07D213/04 ; C07D213/38 ; C07D213/56 ; C07D335/02
摘要:
The present invention provides a compound having a lysine-specific demethylase 1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for cancer, and central nervous system diseases, and the like. The present invention relates to a compound represented by the formula wherein A is a hydrocarbon group or heterocyclic group optionally having substituent(s); R is H, a hydrocarbon group or heterocyclic group optionally having substituent(s); A and R are optionally bonded to each other to form a ring optionally having substituent(s); Q1, Q2, Q3 and Q4 are each a hydrogen atom or a substituent; Q1 and Q2, and Q3 and Q4, are each optionally bonded to each other to form a ring optionally having substituent(s); X is H, an acyclic hydrocarbon group or saturated cyclic group optionally having substituent(s); Y1, Y2 and Y3 are each H, a hydrocarbon group or heterocyclic group optionally having substituent(s); X and Y1, and Y1 and Y2, are each optionally bonded to each other to form a ring optionally having substituent(s); and Z1, Z2 and Z3 are each H or a substituent, or a salt thereof.
公开/授权文献
- US20140228405A1 CYCLOPROPANEAMINE COMPOUND 公开/授权日:2014-08-14
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