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公开(公告)号:US09278931B2
公开(公告)日:2016-03-08
申请号:US14237440
申请日:2012-08-08
申请人: Naoki Tomita , Shigeo Kajii , Douglas Robert Cary , Daisuke Tomita , Shinichi Imamura , Ken Tsuchida , Satoru Matsuda , Ryujiro Hara , Yusuke Tominari
发明人: Naoki Tomita , Shigeo Kajii , Douglas Robert Cary , Daisuke Tomita , Shinichi Imamura , Ken Tsuchida , Satoru Matsuda , Ryujiro Hara , Yusuke Tominari
IPC分类号: A61K31/167 , A61K31/435 , A61K31/415 , A61K31/382 , C07D295/14 , C07D231/14 , C07D231/56 , C07D231/20 , C07D231/22 , C07C233/80 , C07C271/22 , C07C235/56 , C07C237/40 , C07D211/98 , A61K31/36 , A61K31/366 , A61K31/381 , A61K31/40 , A61K31/402 , A61K31/4035 , A61K31/404 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/428 , A61K31/429 , A61K31/433 , A61K31/4406 , A61K31/4409 , A61K31/4453 , A61K31/4468 , A61K31/451 , A61K31/495 , A61K31/55 , C07D309/14 , C07D317/58 , C07D223/16 , C07D333/20 , C07D233/61 , C07D233/64 , C07D405/04 , C07D239/36 , C07D409/04 , C07D471/04 , C07D261/08 , C07D261/10 , C07D263/32 , C07D263/34 , C07D207/06 , C07D495/04 , C07D207/337 , C07D277/20 , C07D277/28 , C07D277/30 , C07D209/08 , C07D277/62 , C07D209/42 , C07D513/04 , C07D209/46 , C07D209/48 , C07D285/06 , C07D211/56 , C07D211/58 , C07D211/76 , C07D213/04 , C07D213/38 , C07D213/56 , C07D335/02
CPC分类号: C07C233/80 , A61K31/167 , A61K31/36 , A61K31/366 , A61K31/381 , A61K31/40 , A61K31/402 , A61K31/4035 , A61K31/404 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/428 , A61K31/429 , A61K31/433 , A61K31/4406 , A61K31/4409 , A61K31/4453 , A61K31/4468 , A61K31/451 , A61K31/495 , A61K31/55 , C07C235/56 , C07C237/40 , C07C237/42 , C07C271/20 , C07C271/22 , C07C2601/02 , C07C2601/18 , C07C2602/08 , C07D207/06 , C07D207/337 , C07D209/08 , C07D209/42 , C07D209/46 , C07D209/48 , C07D211/40 , C07D211/56 , C07D211/58 , C07D211/76 , C07D211/98 , C07D213/04 , C07D213/38 , C07D213/56 , C07D223/16 , C07D231/14 , C07D231/20 , C07D231/22 , C07D231/26 , C07D231/56 , C07D233/61 , C07D233/64 , C07D239/36 , C07D261/08 , C07D261/10 , C07D263/32 , C07D263/34 , C07D277/20 , C07D277/28 , C07D277/30 , C07D277/62 , C07D285/06 , C07D295/135 , C07D295/14 , C07D295/155 , C07D309/14 , C07D317/58 , C07D333/20 , C07D335/02 , C07D405/04 , C07D409/04 , C07D471/04 , C07D495/04 , C07D513/04
摘要: The present invention provides a compound having a lysine-specific demethylase 1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for cancer, and central nervous system diseases, and the like. The present invention relates to a compound represented by the formula wherein A is a hydrocarbon group or heterocyclic group optionally having substituent(s); R is H, a hydrocarbon group or heterocyclic group optionally having substituent(s); A and R are optionally bonded to each other to form a ring optionally having substituent(s); Q1, Q2, Q3 and Q4 are each a hydrogen atom or a substituent; Q1 and Q2, and Q3 and Q4, are each optionally bonded to each other to form a ring optionally having substituent(s); X is H, an acyclic hydrocarbon group or saturated cyclic group optionally having substituent(s); Y1, Y2 and Y3 are each H, a hydrocarbon group or heterocyclic group optionally having substituent(s); X and Y1, and Y1 and Y2, are each optionally bonded to each other to form a ring optionally having substituent(s); and Z1, Z2 and Z3 are each H or a substituent, or a salt thereof.
摘要翻译: 本发明提供具有赖氨酸特异性脱甲基酶1抑制作用的化合物,可用作癌症用预防或治疗剂等中药物等中药用药物。 本发明涉及由下式表示的化合物:其中A是任选具有取代基的烃基或杂环基; R是H,任选具有取代基的烃基或杂环基; A和R可以任选地彼此键合形成任选具有取代基的环; Q1,Q2,Q3和Q4各自为氢原子或取代基; Q1和Q2以及Q3和Q4各自任选地彼此结合形成任选具有取代基的环; X是H,任选具有取代基的无环烃基或饱和环基; Y 1,Y 2和Y 3各自为H,任选具有取代基的烃基或杂环基; X和Y1以及Y 1和Y 2各自任选地彼此键合以形成任选具有取代基的环; 并且Z 1,Z 2和Z 3各自为H或取代基,或其盐。
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公开(公告)号:US20140228405A1
公开(公告)日:2014-08-14
申请号:US14237440
申请日:2012-08-08
申请人: Naoki Tomita , Shigeo Kajii , Douglas Robert Cary , Daisuke Tomita , Shinichi Imamura , Ken Tsuchida , Satoru Matsuda , Ryujiro Hara
发明人: Naoki Tomita , Shigeo Kajii , Douglas Robert Cary , Daisuke Tomita , Shinichi Imamura , Ken Tsuchida , Satoru Matsuda , Ryujiro Hara
IPC分类号: C07C233/80 , C07D231/14 , C07D335/02 , C07D211/98
CPC分类号: C07C233/80 , A61K31/167 , A61K31/36 , A61K31/366 , A61K31/381 , A61K31/40 , A61K31/402 , A61K31/4035 , A61K31/404 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/428 , A61K31/429 , A61K31/433 , A61K31/4406 , A61K31/4409 , A61K31/4453 , A61K31/4468 , A61K31/451 , A61K31/495 , A61K31/55 , C07C235/56 , C07C237/40 , C07C237/42 , C07C271/20 , C07C271/22 , C07C2601/02 , C07C2601/18 , C07C2602/08 , C07D207/06 , C07D207/337 , C07D209/08 , C07D209/42 , C07D209/46 , C07D209/48 , C07D211/40 , C07D211/56 , C07D211/58 , C07D211/76 , C07D211/98 , C07D213/04 , C07D213/38 , C07D213/56 , C07D223/16 , C07D231/14 , C07D231/20 , C07D231/22 , C07D231/26 , C07D231/56 , C07D233/61 , C07D233/64 , C07D239/36 , C07D261/08 , C07D261/10 , C07D263/32 , C07D263/34 , C07D277/20 , C07D277/28 , C07D277/30 , C07D277/62 , C07D285/06 , C07D295/135 , C07D295/14 , C07D295/155 , C07D309/14 , C07D317/58 , C07D333/20 , C07D335/02 , C07D405/04 , C07D409/04 , C07D471/04 , C07D495/04 , C07D513/04
摘要: The present invention provides a compound having a lysine-specific demethylase 1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for cancer, and central nervous system diseases, and the like. The present invention relates to a compound represented by the formula wherein A is a hydrocarbon group or heterocyclic group optionally having substituent(s); R is H, a hydrocarbon group or heterocyclic group optionally having substituent(s); A and R are optionally bonded to each other to form a ring optionally having substituent(s); Q1, Q2, Q3 and Q4 are each a hydrogen atom or a substituent; Q1 and Q2, and Q3 and Q4, are each optionally bonded to each other to form a ring optionally having substituent(s); X is H, an acyclic hydrocarbon group or saturated cyclic group optionally having substituent(s); Y1, Y2 and Y3 are each H, a hydrocarbon group or heterocyclic group optionally having substituent(s); X and Y1, and Y1 and Y2, are each optionally bonded to each other to form a ring optionally having substituent(s); and Z1, Z2 and Z3 are each H or a substituent, or a salt thereof.
摘要翻译: 本发明提供具有赖氨酸特异性脱甲基酶1抑制作用的化合物,可用作癌症用预防或治疗剂等中药物等中药用药物。 本发明涉及由下式表示的化合物:其中A是任选具有取代基的烃基或杂环基; R是H,任选具有取代基的烃基或杂环基; A和R可以任选地彼此键合形成任选具有取代基的环; Q1,Q2,Q3和Q4各自为氢原子或取代基; Q1和Q2以及Q3和Q4各自任选地彼此结合形成任选具有取代基的环; X是H,任选具有取代基的无环烃基或饱和环基; Y 1,Y 2和Y 3各自为H,任选具有取代基的烃基或杂环基; X和Y1以及Y 1和Y 2各自任选地彼此键合以形成任选具有取代基的环; 并且Z 1,Z 2和Z 3各自为H或取代基,或其盐。
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公开(公告)号:US20070135960A1
公开(公告)日:2007-06-14
申请号:US10536179
申请日:2003-11-25
申请人: Satoru Shibao , Naoki Tomita
发明人: Satoru Shibao , Naoki Tomita
IPC分类号: B29C39/00
CPC分类号: G05B19/4185 , G05B19/41875 , G05B2219/32179 , G05B2219/32186 , G06Q10/06 , Y02P90/18 , Y02P90/22
摘要: A production evaluation managing system in a factory including facilities in a plurality of production processes from materials to products and a means for evaluating the products based on at least one of inspection and testing characterized by comprising a network connecting the facilities in respective production processes with the evaluating means, and a means for collecting through the network field data of the facility in a production process pertaining to the production of a product corresponding to the information of evaluation results, based on the information of evaluation results of the products outputted from the evaluating means. By this, when a nonconformity is found from the information of evaluation results based on at least one of inspection and testing of the product, field data of the facility in a production process pertaining to production of a product corresponding to the information of evaluation results can be collected and analyzed immediately and the problem with the production process can be investigated immediately in a short time.
摘要翻译: 一种工厂中的生产评估管理系统,包括从材料到产品的多个生产过程中的设施,以及基于检查和测试中的至少一个来评估产品的手段,其特征在于包括将各个生产过程中的设施与 评估装置,以及基于从评价装置输出的产品的评价结果的信息,在与生产对应于评价结果的信息的产品相关的生产过程中通过网络收集设施的现场数据的手段 。 由此,当基于产品的检查和测试中的至少一个从评估结果的信息中找到不合格时,与生产与产品评价结果信息对应的产品的生产过程中的设备的现场数据可以 立即收集和分析,生产过程中的问题可以在短时间内立即进行调查。
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公开(公告)号:US20090270361A1
公开(公告)日:2009-10-29
申请号:US12383502
申请日:2009-03-25
申请人: Mitsuhiro Ito , Naoki Tomita , Tomohiro Kaku , Tomohiko Suzaki
发明人: Mitsuhiro Ito , Naoki Tomita , Tomohiro Kaku , Tomohiko Suzaki
IPC分类号: A61K31/4155 , C07D231/12 , A61K31/415 , A61K31/4439 , C07D401/12 , C07D403/10 , A61P35/00
CPC分类号: C07D231/12 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/12 , C07D413/10 , C07D413/12 , C07D417/12
摘要: The present invention aims to provide a novel pyrazole derivative and a pharmaceutical agent containing the same. The present invention provides a compound represented by the formula (I′) wherein R1′ is (1) a hydrogen atom, (2) a group via a carbon atom, (3) a group via a nitrogen atom, (4) a group via an oxygen atom or (5) a group via a sulfur atom; R2′ is an aromatic ring group optionally having substituent(s); R3′ is (1) a hydrogen atom, (2) a group via a carbon atom, (3) a group via a nitrogen atom, (4) a group via an oxygen atom or (5) a group via a sulfur atom; R4′ is a cyanophenyl group optionally having substituent(s); X′ is (1) —Y′—CR5′R6′-Z′- wherein R5′ and R6′ are the same or different and each is a hydrogen atom, a group via a carbon atom, a group via a nitrogen atom, a group via an oxygen atom or a group via a sulfur atom, or —CR5′R6′— is —C(alkylidene)-; Y′ is a bond, —COCO—, —CONH—, —COCONH— or —O—; and Z′ is a bond, —CH2—, —CONH—, —O—, —OCH2—, —S—, —SO—, —SO2—, —CON(C6H5)— or (2) —CO(CONH)n— wherein n is 0 or 1, (3) —NHCO—, (4) —CONH—, (5) —O—, (6) —CH═CH— or (7) —O(C1-3 alkylene)O—; (excluding the compounds indicated to be excluded from the specification), or a salt thereof.
摘要翻译: 本发明的目的在于提供一种新的吡唑衍生物和含有它们的药剂。 本发明提供由式(I')表示的化合物,其中R 1'为(1)氢原子,(2)通过碳原子的基团,(3)通过氮原子的基团,(4) 通过氧原子或(5)经由硫原子的基团; R2'是任选具有取代基的芳环基团; R 3'为(1)氢原子,(2)经由碳原子的基团,(3)经由氮原子的基团,(4)经由氧原子的基团或(5)经由硫原子的基团; R4'是任选具有取代基的氰基苯基; X'为(1)-Y'-CR5'R6'-Z'-,其中R5'和R6'相同或不同,各自为氢原子,经由碳原子的基团,经由氮原子的基团, 一个经由氧原子或一个经由硫原子的基团,或-CR 5'R 6' - 是-C(亚烷基) - ; Y'是键,-COCO - , - CONH-,-COCONH-或-O-; 并且Z'为键,-CH 2 - , - CONH - , - O - , - OCH 2 - , - S - , - SO - , - SO 2 - , - CON(C 6 H 5) - 或(2)-CO 其中n为0或1,(3)-NHCO-,(4)-CONH-,(5)-O-,(6)-CH-CH-或(7)-O(C1-3亚烷基) O-; (不包括表示从说明书中排除的化合物)或其盐。
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公开(公告)号:US20080125437A1
公开(公告)日:2008-05-29
申请号:US11876635
申请日:2007-10-22
申请人: Qing DONG , Victoria Feher , Stephen W. Kaldor , Naoki Tomita
发明人: Qing DONG , Victoria Feher , Stephen W. Kaldor , Naoki Tomita
IPC分类号: A61K31/495 , A61K31/496 , A61K31/4965 , C07D403/02
CPC分类号: C07D239/545 , C07D239/557 , C07D401/12 , C07D403/06 , C07D405/12 , C07D413/06
摘要: Compounds, pharmaceutical compositions, kits and methods are provided for use with MEK that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.
摘要翻译: 提供化合物,药物组合物,试剂盒和方法用于包含选自以下的化合物的MEK:其中变量如本文所定义。
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公开(公告)号:US20100204471A1
公开(公告)日:2010-08-12
申请号:US12446974
申请日:2007-10-22
申请人: Qing Dong , Victoria Feher , Stephen W. Kaldor , Naoki Tomita
发明人: Qing Dong , Victoria Feher , Stephen W. Kaldor , Naoki Tomita
IPC分类号: C07D413/02 , C07D239/10 , C07D405/02
CPC分类号: C07D239/545 , C07D239/557 , C07D401/12 , C07D403/06 , C07D405/12 , C07D413/06
摘要: Compounds, pharmaceutical compositions, kits and methods are provided for use with MEK that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.
摘要翻译: 提供化合物,药物组合物,试剂盒和方法用于包含选自以下的化合物的MEK:其中变量如本文所定义。
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公开(公告)号:US07335097B2
公开(公告)日:2008-02-26
申请号:US10304999
申请日:2002-11-27
申请人: Naoki Tomita , Tadashi Obara
发明人: Naoki Tomita , Tadashi Obara
CPC分类号: B41L1/22
摘要: A document carrier sheet is provided with a support sheet having a support surface on which a document is supported. The document carrier sheet is also provided with a transparent sheet attached to the support sheet and permitting the document to be held on the support surface, with an image on the document being covered. The support surface of the support sheet has a different color from that of the document.
摘要翻译: 文件载体片设置有具有支撑表面的支撑片,文件支撑在该支撑表面上。 文件载体片还设置有附接到支撑片材的透明片材,并且允许文件被保持在支撑表面上,并且文件上的图像被覆盖。 支撑片的支撑表面具有与文档不同的颜色。
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