Invention Grant
US09567604B2 Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing
有权
使用截短的引导RNA（tru-gRNA）增加RNA指导基因组编辑的特异性
- Patent Title: Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing
- Patent Title (中): 使用截短的引导RNA（tru-gRNA）增加RNA指导基因组编辑的特异性
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Application No.: US14213723Application Date: 2014-03-14
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Publication No.: US09567604B2Publication Date: 2017-02-14
- Inventor: J. Keith Joung , Jeffry D. Sander , Morgan Maeder , Yanfang Fu
- Applicant: The General Hospital Corporation
- Applicant Address: US MA Boston
- Assignee: The General Hospital Corporation
- Current Assignee: The General Hospital Corporation
- Current Assignee Address: US MA Boston
- Agency: Fish & Richardson P.C.
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C12N15/00 ; A61K48/00 ; C12N15/85 ; C12N9/22 ; C12N15/63 ; C07K14/005 ; C07K14/195 ; C12N9/02 ; C12N9/10 ; C12N9/16 ; C12N9/96 ; C12N15/01
Abstract:
Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems, using truncated guide RNAs (tru-gRNAs).
Public/Granted literature
- US20140295557A1 Using Truncated Guide RNAs (tru-gRNAs) to Increase Specificity for RNA-Guided Genome Editing Public/Granted day:2014-10-02
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