Technology for reducing coexistence interference in a multi-radio device is disclosed. One method comprises applying discontinuous reception (DRX) to a user equipment (UE) having a plurality of radio transceivers. The DRX can include a long DRX cycle for the UE. One of a 2 milliseconds (ms), 5 ms, and 8 ms cycle start offset period may be provided for the long DRX cycle to reduce coexistence interference between the plurality of radio transceivers in the UE. The cycle start offset period is selected to provide at least one Hybrid Automatic Repeat Request (HARQ) process reservation pattern to reduce the coexistence interference between the plurality of radio transceivers in the UE.