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公开(公告)号：EP3623370A1
公开(公告)日：2020-03-18
申请号：EP18382659.3
申请日：2018-09-13
发明人： PASTOR FERNANDEZ, Joaquin Angel , BLASCO MARHUENDA, Maria Antonia , MARTINEZ GONZALEZ, Sonia , BLANCO-APARICIO, Carmen , GARCIA GARCIA, Ana Belen , VARELA BUSTO, Carmen , GOMEZ-CASERO ESTEBAN, Elena , BEJARANO BOSQUE, Leire , MENDEZ PERTUZ, Marinela , MARTINEZ RODRIGUEZ, Paula , GARCIA-BECCARIA, Maria
IPC分类号： C07D417/12 , A61P35/00 , A61K31/4439 , A61K31/506
摘要： Novel TRF1 modulators and analogues thereof.
There is provided compounds of Formula I, wherein R, R1, R2 and X have meanings written in the description. Such compounds are useful as TRF1 inhibitors and, for that reason, as medicaments, in the treatment of cancer, particularly high cancer stem cell cancer like glioblastoma and lung cancer, and can be also useful for the development of additional TRF1 inhibitors and increasing knowledge about TRF1 activity.-
公开(公告)号：EP4118082A1
公开(公告)日：2023-01-18
申请号：EP21767406.8
申请日：2021-03-15
申请人： Prosenestar LLC , Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III (F.S.P. CNIO) , Salazar-Roa, María
发明人： MALUMBRES, Marcos , ALVAREZ-FERNÁNDEZ, Mónica , ZAPATERO, Elisabet , SANCHEZ, Juan , SALAZAR-ROA, María
IPC分类号： C07D471/04 , A61K31/505 , A61K31/519 , A61P35/00
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公开(公告)号：EP4089171A1
公开(公告)日：2022-11-16
申请号：EP21382441.0
申请日：2021-05-12
申请人： Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III (F.S.P. CNIO) , Universitat Autònoma de Barcelona
发明人： BLASCO, Maria , MARTINEZ, Paula , BOSCH TUBERT, Maria Fàtima , JIMENEZ CENZANO, Verónica , GARCIA MARTINEZ, Miquel , CASANA LORENTE, Estefanía
IPC分类号： C12N15/86 , C12N15/861 , A61K48/00
摘要： Described herein are recombinant viral genomes comprising a nucleotide sequence encoding a telomerase reverse transcriptase (TERT) operably linked to a tissue-specific and/or organ-specific promoter. Aspects described herein may be used in the treatment of conditions associated with shortened telomere length, such as pulmonary fibrosis, myocardial infarction and conditions associated therewith.
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5.发明公开
公开(公告)号：EP3939999A1
公开(公告)日：2022-01-19
申请号：EP20382631.8
申请日：2020-07-14
申请人： Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III (F.S.P. CNIO) , Fundación Investigación Biomédica Hospital Universitario 12 de Octubre
发明人： OJEDA MÁRQUEZ, Laura , FERRER SÁNCHEZ, Irene , PAZ-ARES RODRÍGUEZ, Luis , MARTÍNEZ TORRECUADRADA, Jorge Luis , RONCADOR, Giovanna
摘要： The present invention relates to neutralizing antibodies which specifically recognize the interleukin 11 receptor alpha subunit (IL11RA) extracellular domain and to antibody drug conjugates (ADCs) comprising a therapeutic agent and said neutralizing antibodies. The invention also relates to a method for detecting the IL-11 receptor, to pharmaceutical compositions and to the use of said antibodies or ADCs in the treatment of diseases characterized by an increased IL11RA signaling.
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公开(公告)号：EP3867363A1
公开(公告)日：2021-08-25
申请号：EP19786816.9
申请日：2019-10-18
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公开(公告)号：EP3630954A1
公开(公告)日：2020-04-08
申请号：EP18727784.3
申请日：2018-05-25
IPC分类号： C12N5/077 , A61K35/34 , C12N15/11 , C12N15/113 , C12N5/074 , C12N5/0735 , A01K67/027
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公开(公告)号：EP3623009A1
公开(公告)日：2020-03-18
申请号：EP18382658.5
申请日：2018-09-13
发明人： BLASCO MARHUENDA, Maria Antonia , PASTOR FERNANDEZ, Joaquin Angel , BEJARANO BOSQUE, Leire , MENDEZ PERTUZ, Marinela , MARTINEZ RODRIGUEZ, Paula , BLANCO-APARICIO, Carmen , GOMEZ-CASERO ESTEBAN, Elena , GARCIA-BECCARIA, Maria
IPC分类号： A61P35/00 , A61K31/4985 , A61K45/06
摘要： The invention provides TRF1 inhibitors and compositions comprising them for the treatment of a brain cancer, such as a glioblastoma, and particularly a glioblastoma multiforme (GBM). PI3K inhibitors can be among the TRF1 inhibitors used. The compositions can comprise more than one TRF1 inhibitor, being particularly advantageous that at least one of the inhibitors is a PI3K inhibitor and that at least a second possible TRF1 inhibitor present is selected from the group an RTK inhibitor, a MEK inhibitor, an ERK inhibitor, an HSP90 inhibitor, docetaxel and gemcitabine, because such compositions show a synergic effect. The invention also relates to a method for identifying compounds candidates to be used for treating glioblastoma or other cancers, which method is based on the identification of the compound as a TRF1 inhibitor.
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公开(公告)号：EP3598973A1
公开(公告)日：2020-01-29
申请号：EP18382555.3
申请日：2018-07-24
IPC分类号： A61K31/395 , C07K16/28 , A61K39/395 , A61P35/00
摘要： The present invention relates to a pharmaceutical composition comprising an inhibitor of the expression, activity and/or function of c-Raf and an inhibitor of the expression, activity and/or function of EGF Receptor (EGFR) and its use in the treatment of pancreatic cancer.
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公开(公告)号：EP4441052A1
公开(公告)日：2024-10-09
申请号：EP22803213.2
申请日：2022-10-14
发明人： FERNÁNDEZ, Joaquin Pastor , BLANCO APARICIO, Carmen , MARTÍNEZ GONZÁLEZ, Sonia , ALBARRÁN SANTIÑO, María Isabel , ÁLVAREZ ESCOBAR, Rosa María , CEBRIÁ GÓMEZ, Antonio , CEBRIÁN MUÑOZ, David Álvaro , GARCÍA GARCÍA, Ana Belén , GÓMEZ DE LA OLIVA, Cristina Ana , GONZÁLEZ CANTALAPIEDRA, Esther , HERNÁNDEZ ENCINAS, Elena , MARTÍN HERNANDO, Jose Ignacio , RAMOS LIMA, Francisco Javier , RIESCO FAGUNDO, Rosario Concepción
IPC分类号： C07D491/147 , C07D498/14 , A61P3/00 , A61P3/10 , A61P7/02 , A61P9/00 , A61P17/06 , A61P19/08 , A61P25/00 , A61P25/28 , A61P29/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/00 , A61K31/5025 , A61K31/5383
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