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公开(公告)号：EP2698386A1
公开(公告)日：2014-02-19
申请号：EP12770896.4
申请日：2012-04-02
CPC分类号： C07K16/42 , A61K38/00 , C07K14/705 , C07K2319/00 , C07K2319/30
摘要： The present invention provides a new fusion protein which can specifically suppress the autoantibodies, which can effectively prevent or treat the autoimmune disease of autoantibody type, and which can be expressed in an amount sufficient for industrial production.
A fusion protein, characterized in that, a protein (X) containing a site recognized by autoantibodies which are a cause of the autoimmune disease of autoantibody type is connected to a protein (A) containing a fragment of the antibody heavy chain constant region which exhibits the antibody-dependent cellular cytotoxicity with a linker peptide (L) consisting of one or more amino acid (s), wherein the protein (X), the linker peptide (L) and the protein (A) are connected in this order by means of peptide bond from N terminal to C terminal.摘要翻译： 本发明提供了一种能特异性抑制自身抗体的新型融合蛋白，能够有效预防或治疗自身抗体型自身免疫性疾病，并且其表达量足以用于工业生产。 1。一种融合蛋白，其特征在于，含有被自身抗体型自身免疫病的原因的自身抗体识别的位点的蛋白质（X）与含有抗体重链恒定区片段的蛋白质（A）连接， 使用由一个或多个氨基酸组成的接头肽（L）的抗体依赖性细胞毒性，其中蛋白质（X），接头肽（L）和蛋白质（A）以此顺序通过手段连接 肽键从N末端到C末端。
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2.发明公开
公开(公告)号：EP2140874A4
公开(公告)日：2010-10-20
申请号：EP08740701
申请日：2008-04-21
发明人： SASAKI TETSUYA , HARA NAOKO , ISHIKAWA MAKOTO
CPC分类号： A61K38/1709
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3.发明公开
公开(公告)号：EP2140874A1
公开(公告)日：2010-01-06
申请号：EP08740701.1
申请日：2008-04-21
发明人： SASAKI, Tetsuya , HARA, Naoko , ISHIKAWA, Makoto
CPC分类号： A61K38/1709
摘要： When acute hepatitis progresses to fulminant hepatitis, a large amount of hepatic cells are rapidly broken, and as a result, the prognosis is seriously worsened. Thus, it is important to prognose the progress of acute hepatitis into fulminant hepatitis at an early stage and quickly start an appropriate treatment therefor. Although the prognosis of progress into fulminant hepatitis becomes possible owing to recent advances in test methods and diagnostic techniques, there has been no appropriate prophylactic/therapeutic agent for fulminant hepatitis. The present invention provides a therapeutic agent for acute hepatitis or a prophylactic/therapeutic agent for fulminant hepatitis with little side effect. The problem of the invention was solved by using a composition containing apolipoprotein A-II.
摘要翻译： 当急性肝炎发展为爆发性肝炎，大量的肝细胞的迅速破裂，并且作为结果，预后严重恶化。 因此，在预测急性肝炎到爆发性肝炎的进展，在早期阶段，并开始迅速适当治疗为此是非常重要的。 虽然由于在测试方法和诊断技术的最新进展的进展预后成暴发性肝炎成为可能，出现了对暴发性肝炎没有适当的预防/治疗剂。 本发明提供了用于急性肝炎或副作用少暴发性肝炎的预防/治疗剂的治疗剂。 本发明的通过使用含有载脂蛋白A-II的组合物是什么解决了这个问题。
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公开(公告)号：EP1506774A1
公开(公告)日：2005-02-16
申请号：EP03752931.0
申请日：2003-05-20
IPC分类号： A61K31/045 , A61K9/107 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/34 , A61K47/44 , A61P1/00 , A61P43/00
CPC分类号： A61K31/045 , A61K9/1075
摘要： An emulsion comprising L-Menthol, a fat or oil and a surfactant wherein oil particles have an average diameter of 100 nm or less inhibits a content reduction attributed to, for example, evaporation of L-menthol, enhances a light transmission through liquid and is stable despite long-term storage. Thus, the emulsion can be appropriately used in the temporary inhibition of contraction of gastrointestinal tract for, for example, observation of gastrointestinal tract by an endoscope. This emulsion can be obtained by heating an oil-in-water type emulsion comprising L-menthol, a fat or oil and a surfactant at 60°C or higher.
摘要翻译： 包含L-薄荷醇，脂肪或油和表面活性剂的乳液，其中油颗粒具有100nm或更小的平均直径抑制由于例如L-薄荷醇的蒸发引起的含量降低，增强了透过液体的透光性，并且是 稳定，尽管长期储存。 因此，乳液可以适当地用于临时抑制胃肠道的收缩，例如通过内窥镜观察胃肠道。 该乳液可以通过在60℃以上加热包含L-薄荷醇，脂肪或油和表面活性剂的水包油型乳液来获得。
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公开(公告)号：EP2698386B1
公开(公告)日：2017-12-20
申请号：EP12770896.4
申请日：2012-04-02
IPC分类号： C07K19/00 , A61K38/00 , A61P37/06 , C07K14/47 , C07K16/18 , C12P21/02 , C12N15/09 , C07K14/705
CPC分类号： C07K16/42 , A61K38/00 , C07K14/705 , C07K2319/00 , C07K2319/30
摘要： The present invention provides a new fusion protein which can specifically suppress the autoantibodies, which can effectively prevent or treat the autoimmune disease of autoantibody type, and which can be expressed in an amount sufficient for industrial production. A fusion protein, characterized in that, a protein (X) containing a site recognized by autoantibodies which are a cause of the autoimmune disease of autoantibody type is connected to a protein (A) containing a fragment of the antibody heavy chain constant region which exhibits the antibody-dependent cellular cytotoxicity with a linker peptide (L) consisting of one or more amino acid (s), wherein the protein (X), the linker peptide (L) and the protein (A) are connected in this order by means of peptide bond from N terminal to C terminal.
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公开(公告)号：EP2783709A4
公开(公告)日：2015-09-30
申请号：EP12851264
申请日：2012-11-21
发明人： NISHIOKA AYUMU
CPC分类号： A61L31/042 , A61L31/14 , A61L31/145 , A61L2400/06 , C08L5/00
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公开(公告)号：EP2698386A4
公开(公告)日：2014-12-03
申请号：EP12770896
申请日：2012-04-02
发明人： KOGURE TAKAHISA , NAKAJIMA KENJI , HOMMA MASAYUKI
IPC分类号： C07K19/00 , A61K38/00 , A61P37/06 , C07K14/47 , C07K14/705 , C07K16/18 , C12N15/09 , C12P21/02
CPC分类号： C07K16/42 , A61K38/00 , C07K14/705 , C07K2319/00 , C07K2319/30
摘要： The present invention provides a new fusion protein which can specifically suppress the autoantibodies, which can effectively prevent or treat the autoimmune disease of autoantibody type, and which can be expressed in an amount sufficient for industrial production. A fusion protein, characterized in that, a protein (X) containing a site recognized by autoantibodies which are a cause of the autoimmune disease of autoantibody type is connected to a protein (A) containing a fragment of the antibody heavy chain constant region which exhibits the antibody-dependent cellular cytotoxicity with a linker peptide (L) consisting of one or more amino acid (s), wherein the protein (X), the linker peptide (L) and the protein (A) are connected in this order by means of peptide bond from N terminal to C terminal.
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公开(公告)号：EP1640022B1
公开(公告)日：2011-12-28
申请号：EP04746565.3
申请日：2004-06-28
发明人： HAMAWAKI, Tomonori C/O OSAKA RES. LABORATORY , KATAOKA, Yosuke C/O OSAKA RES. LABORATORY , ISODA, Takako C/O OSAKA RES. LABORATORY
IPC分类号： A61K31/045 , A61K49/00 , A61K9/107 , A61K47/10 , A61K47/26 , A61K47/34 , A61K47/02 , A61K47/44
CPC分类号： A61K49/00 , A61B1/2736 , A61B1/31 , A61K9/1075 , A61K31/045 , A61K47/14 , A61K47/24 , A61K47/26 , A61K47/44
摘要： It is known that L-menthol soothes smooth muscle motility. In order to use L-menthol in practice as a digestive tract motility soothing agent in digestive tract endoscopy, it is required to devise means of giving a preparation in which an L-menthol-containing solution remains stable and transparent or little cloudy over a long time after the production and which shows little foaming at the administration. To a smooth muscle motility soothing agent or a digestive tract motility soothing agent containing a relatively transparent L-menthol emulsion having an average particle size of less than 100 nm, a defoaming agent is further added. Thus, it is possible to obtain a preparation which remains stable over a long time, has a high light transmittance and suffers from no foaming in filling into a container or topical administration for, e.g., digestive tract endoscopy, thereby facilitating the observation of a disease area.
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9.发明公开Method for preparing a stabilised menthol emulsion 有权Verfahren zur Herstellung einer stableisierten薄荷醇乳液
公开(公告)号：EP2311444A1
公开(公告)日：2011-04-20
申请号：EP11151652.2
申请日：2004-06-28
IPC分类号： A61K31/045 , A61K49/00 , A61K9/107 , A61K47/10 , A61K47/26 , A61K47/34 , A61K47/02 , A61K47/44
CPC分类号： A61K49/00 , A61B1/2736 , A61B1/31 , A61K9/1075 , A61K31/045 , A61K47/14 , A61K47/24 , A61K47/26 , A61K47/44
摘要： It is known that L-menthol controls smooth muscle contraction. In order to use L-menthol in practice as a digestive tract contraction inhibiting agent in digestive tract endoscopy, it is required to devise means of giving a formulation in which an L-menthol-containing formulation remains stable and transparent or little cloudy over a long time after the production and which shows little foaming at the administration. In the present invention, an antifoaming agent is further added to a formulation for inhibiting smooth muscle contraction or a peristaltic contraction in a digestive tract containing a L-menthol emulsion having an average particle size of less than 100nm.
Thus, it is possible to obtain a formulation that remains stable over a long time, has a high light transmittance, and produces little foam when filled into a container and sprayed at a target area to inhibit contraction to facilitate observation of the area in endoscopic examination of the digestive tract etc.摘要翻译： 已知L-薄荷脑控制平滑肌收缩。 为了在实践中使用L-薄荷醇作为消化道内窥镜检查中的消化道收缩抑制剂，需要设计给予其中含L-薄荷醇的制剂保持稳定和透明或长时间多云的制剂的方法 生产后的时间，在施药时几乎没有发泡。 在本发明中，在平均粒径小于100nm的含有L-薄荷醇乳液的消化道中进一步添加抑制平滑肌收缩或蠕动收缩的制剂中的消泡剂。 因此，可以获得长时间保持稳定，具有高透光率的制剂，并且当填充到容器中并且在目标区域喷射以抑制收缩时产生很少的泡沫以便于观察内窥镜检查中的区域 的消化道等
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公开(公告)号：EP1640022A4
公开(公告)日：2008-08-06
申请号：EP04746565
申请日：2004-06-28
发明人： HAMAWAKI TOMONORI , KATAOKA YOSUKE , ISODA TAKAKO
IPC分类号： A61K31/045 , A61B1/273 , A61B1/31 , A61K9/107 , A61K47/02 , A61K47/10 , A61K47/26 , A61K47/34 , A61K47/44 , A61K49/00
CPC分类号： A61K49/00 , A61B1/2736 , A61B1/31 , A61K9/1075 , A61K31/045 , A61K47/14 , A61K47/24 , A61K47/26 , A61K47/44
摘要： It is known that L-menthol controls smooth muscle contraction. In order to use L-menthol in practice as a digestive tract contraction inhibiting agent in digestive tract endoscopy, it is required to devise means of giving a formulation in which an L-menthol-containing formulation remains stable and transparent or little cloudy over a long time after the production and which shows little foaming at the administration. In the present invention, an antifoaming agent is further added to a formulation for inhibiting smooth muscle contraction or a peristaltic contraction in a digestive tract containing a L-menthol emulsion having an average particle size of less than 100nm. Thus, it is possible to obtain a formulation that remains stable over a long time, has a high light transmittance, and produces little foam when filled into a container and sprayed at a target area to inhibit contraction to facilitate observation of the area in endoscopic examination of the digestive tract etc.
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