METHOD FOR SCREENING OF PATIENT TO BE ADMINISTERED WITH PHARMACEUTICAL AGENT COMPRISING ANTI-CANCER ANTIBODY AS ACTIVE INGREDIENT
    1.
    发明公开
    METHOD FOR SCREENING OF PATIENT TO BE ADMINISTERED WITH PHARMACEUTICAL AGENT COMPRISING ANTI-CANCER ANTIBODY AS ACTIVE INGREDIENT 有权
    一种筛选患者给药的药物的方法具有抗癌抗体作为积极的手段

    公开(公告)号:EP2172218A1

    公开(公告)日:2010-04-07

    申请号:EP08777634.0

    申请日:2008-06-26

    IPC分类号: A61K39/395 G01N33/53

    摘要: The present invention provides a method for screening a patient to be administered with a pharmaceutical composition which comprises an anti-cancer antibody as an active ingredient, said method comprising collecting samples from patients who expresses an antigen which is recognized by the anti-cancer antibody, measuring cadherin function in the samples, and selecting a patient whose the cadherin function is decreased or deleted; a method for screening a patient who has a high efficacy ratio for a pharmaceutical composition which comprises an anti-cancer antibody as an active ingredient; and a method for improving an efficacy ratio for a pharmaceutical composition which comprises an anti-cancer antibody as an active ingredient.

    摘要翻译: 本发明提供了以具有抗癌抗体的方法,包括作为活性成分的药物组合物给药用于筛选患者的方法,所述方法包括从谁快车到抗原 - 全部由所述抗癌抗体识别的患者收集的样品, 测量所述样品中的钙粘蛋白的功能,并选择一个患者谁的钙粘蛋白功能降低或缺失; 用于筛选的患者谁具有用于抗癌抗体作为活性成分的,其包含药物组合物的高效力比例的方法; 及用于改善功效比为抗癌抗体的方法,包括如在活性成分的药物组合物的方法。

    Container for suspension and filtration of stool
    3.
    发明公开
    Container for suspension and filtration of stool 审中-公开
    Behälterzur Aufbewahrung und Filtration von Stuhlproben

    公开(公告)号:EP1656887A1

    公开(公告)日:2006-05-17

    申请号:EP05018730.1

    申请日:2005-08-29

    IPC分类号: A61B10/00

    CPC分类号: A61B10/0038 A61B10/0096

    摘要: A container for the suspension and filtration of stool enables quick, simple, and safe collection of cancer cells separated in stool. The container comprises (a) a stool collection container 1, (c) a stool processing container main body 20, and (d) a pushing member 30. The stool collection container 1 comprises a syringe 2 capable of collecting 0.5 g or more of stool by being thrust into stool, a stool collecting opening, a handle 3 provided on the periphery of the syringe at the opposite end to the stool collecting opening, and a cap member 4 provided at the opposite end to the stool collecting opening. The stool processing container main body 20 comprises: a syringe storage portion 21 for storing the syringe; a suspension portion 22 connected to the syringe storage portion for suspending the stool; a filtrate receiving container 23 detachably connected to the suspension portion for receiving a filtrate of the stool that has been suspended and filtered; and a filter 26 provided at a connection portion between the suspension portion and the filtrate receiving container. The pushing member 30 is pressed to press or tear the cap member so as to move the stool collected in the syringe of the stool collection container into the suspension portion.

    摘要翻译: 用于粪便的悬浮和过滤的容器能够快速,简单和安全地收集在粪便中分离的癌细胞。 容器包括(a)粪便收集容器1,(c)粪便处理容器主体20和(d)推动构件30.粪便收集容器1包括能够收集0.5g或更多粪便的注射器2 通过推入粪便,粪便收集口,在与粪便收集口相对的端部处设置在注射器的周边上的把手3和设置在粪便收集口的相对端的帽部件4。 粪便处理容器主体20包括:用于储存注射器的注射器存放部21; 连接到注射器存储部分用于悬挂粪便的悬挂部分22; 滤液接收容器23,其可拆卸地连接到悬挂部分,用于接收已经悬浮和过滤的粪便滤液; 以及设置在悬架部分和滤液接收容器之间的连接部分处的过滤器26。 按压构件30按压或撕开盖构件,以将收集在粪便收集容器的注射器中的粪便移动到悬挂部分中。

    HST-2, a member of the heparin binding growth factor family
    4.
    发明公开
    HST-2, a member of the heparin binding growth factor family 失效
    HST-2,ein Mitglied der Heparin-bindenden Wachstumsfaktoren-Familie。

    公开(公告)号:EP0488196A2

    公开(公告)日:1992-06-03

    申请号:EP91120244.8

    申请日:1991-11-27

    CPC分类号: C07K14/50 A61K38/00

    摘要: Disclosed are (1) an HST2 protein; (2) a recombinant DNA containing a nucleotide sequence coding for the HST2 protein; (3) a vector containing the recombinant DNA; (4) a transformant transformed with the vector; and (5) a method for preparing the protein which comprises cultivating the transformant and accumulating the protein in a culture broth, whereby the HST2 protein can be produced in high purity and in large amounts which is applicable to wound healing, or repair of the cardiac muscle or the nervous tissue after ischemia.

    摘要翻译: 公开了(1)HST2蛋白; (2)含有编码HST2蛋白的核苷酸序列的重组DNA; (3)含有重组DNA的载体; (4)用载体转化的转化体; (5)一种蛋白质的制备方法,其特征在于,培养上述转化体并在培养液中积聚蛋白质,从而能够以高纯度,大量生产适用于伤口愈合或心脏修复的HST2蛋白质 肌肉或神经组织缺血后。