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公开(公告)号：EP1625126A1
公开(公告)日：2006-02-15
申请号：EP04731525.4
申请日：2004-05-06
申请人： AstraZeneca AB
IPC分类号： C07D471/04 , C07D513/04 , C07D498/04 , A61K31/437 , A61P11/06 , A61P37/00 , A61P19/02
CPC分类号： C07D513/04 , C07D471/04
摘要： The present invention relates to novel imidazo and thiazolopyridine compounds which are kinase inhibitors, methods for their preparation intermediates and pharmaceutical compositions comprising them. Formula (I)
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2.发明授权
公开(公告)号：EP2097384B1
公开(公告)日：2012-09-12
申请号：EP07835228.3
申请日：2007-11-22
发明人： BERGER, Markus , BERGSTRÖM, Lena , DAHMÉN, Jan , ERIKSSON, Anders , GABOS, Balint , HEMMERLING, Martin , HENRIKSSON, Krister , IVANOVA, Svetlana , LEPISTÖ, Matti , MCKERRECHER, Darren , NILSSON, Stinabritt , REHWINKEL, Hartmut , TAFLIN, Camilla
IPC分类号： C07D231/56 , A61K31/416 , A61K31/454 , A61K31/4545 , A61P11/00 , A61P29/00 , A61P35/00 , A61P37/06 , A61P37/08 , C07D401/04 , C07D401/14
CPC分类号： C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/12
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公开(公告)号：EP2291359A1
公开(公告)日：2011-03-09
申请号：EP09750864.2
申请日：2009-05-20
发明人： BAYER SCHERING PHARMA AG , BERGER, Markus , DAHMEN, Jan , EDMAN Karl , HANSSON, Thomas , HEMMERLING, Martin , HOSSAIN, Nafizal , JOHANSSON, Henrik , LEPISTÖ, Matti , NILSSON, Stinabritt , REHWINKEL, Hartmut
IPC分类号： C07D231/56 , A61K31/416 , A61K31/422 , A61K31/4439 , A61K31/444 , A61P11/00 , A61P29/00 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/12
CPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/12
摘要： A compound of formula Ia: Formula (la) The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments.
摘要翻译： 式Ia化合物：本发明涉及新的吲唑基衍生物，包含这些衍生物的药物组合物，制备这种新衍生物的方法以及使用这些衍生物作为药物
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公开(公告)号：EP1263724B1
公开(公告)日：2005-05-18
申请号：EP01908557.0
申请日：2001-02-23
申请人： AstraZeneca AB
发明人： BODKIN, Michael Lilly Research Centre , ERIKSSON, Tomas , HANSEN, Peter , HEMMERLING, Martin , HENRIKSSON, Krister , KLINGSTEDT, Tomas , PETTERSSON, Lars
IPC分类号： C07D207/04 , C07D211/06 , C07D295/08 , A61K31/40 , A61K31/435 , A61P11/00 , A61P37/00 , A61P19/00 , A61P31/00
CPC分类号： C07D207/08 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/22 , C07D211/46 , C07D211/58 , C07D295/088 , C07D401/12 , C07D403/12 , C07D471/04
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5.发明授权3,4-DIAMINO-6-CHLOROPYRAZINE-2-CARBOXAMIDE COMPOUNDS FOR THE TREATMENT OF ENAC MEDIATED DISEASES 有权3,4-二氨基-6-氯吡嗪-2-羧酰胺类化合物用于治疗ENAC介导的疾病
公开(公告)号：EP3119752B1
公开(公告)日：2018-05-16
申请号：EP15713339.8
申请日：2015-03-17
申请人： Astrazeneca AB
发明人： BERGLUND, Susanne, Elisabeth , CONNOLLY, Stephen , HEMMERLING, Martin , HOSSAIN, Nafizal , KRISTOFFERSSON, Anna , LUNDKVIST, Johan, Rune, Michael , NIKITIDIS, Grigorios , RIPA, Lena, Elisabeth , SHAMOVSKY, Igor
IPC分类号： C07D401/06 , C07D241/28 , A61K31/497 , A61P11/00
CPC分类号： C07D401/12 , A61K31/4965 , A61K31/497 , A61K45/06 , C07D241/26 , C07D241/28 , C07D401/06
摘要： The present invention provides a compound of a formula (I): or a pharmaceutically acceptable salt thereof; a process for preparing such a compound; and to the use of such a compound in the treatment of an ENaC mediated disease state (such as asthma, CF or COPD).
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6.发明授权INDAZOLYL AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS 有权INDAZOLYLAMIDDERIVATE用于治疗由糖皮质激素介导的疾病
公开(公告)号：EP2102169B1
公开(公告)日：2012-06-20
申请号：EP07852132.5
申请日：2007-12-20
发明人： BERGER, Markus , DAHMÉN, Jan , ERIKSSON, Anders , GABOS, Balint , HANSSON, Thomas , HEMMERLING, Martin , HENRIKSSON, Krister , IVANOVA, Svetlana , LEPISTÖ, Matti , McKERRECHER, Darren , MUNCK AF ROSENSCHÖLD, Magnus , NILSSON, Stinabritt , REHWINKEL, Hartmut , TAFLIN, Camilla , EDMAN, Karl
IPC分类号： C07D231/56 , A61K31/416 , A61K31/4709 , A61P11/06 , A61P17/06 , A61P29/00 , A61P37/00 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
CPC分类号： C07D231/56 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Compounds of formula (I): The present invention relates to novel indazolyl ester or amide derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments
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7.发明公开PHENYL AND BENZODIOXINYL SUBSTITUTED INDAZOLES DERIVATIVES 有权BENZODIOXINYL-SUBSTITUIERTE INDAZOLDERIVATE
公开(公告)号：EP2291369A1
公开(公告)日：2011-03-09
申请号：EP09750866.7
申请日：2009-05-20
申请人： AstraZeneca AB
发明人： BAYER SCHERING PHARMA AG , BERGER, Markus , DAHMEN, Jan , EDMAN, Karl , ERIKSSON, Anders , HANSSON, Thomas , HEMMERLING, Martin , HOSSAIN Nafizal , KLINGSTEDT, Tomas , LEPISTÖ, Matti , NILSSON, Stinabritt , REHWINKEL, Hartmut
IPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61P11/00 , A61P29/00 , C07D407/12 , C07D407/14
CPC分类号： C07D409/14 , A61K31/416 , A61K31/4439 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/12
摘要： A compound of formula la: (Ia) The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments.
摘要翻译： 式Ia化合物：本发明涉及新的吲唑基衍生物，包含这些衍生物的药物组合物，制备这种新衍生物的方法以及使用这些衍生物作为药物
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公开(公告)号：EP3119752A1
公开(公告)日：2017-01-25
申请号：EP15713339.8
申请日：2015-03-17
申请人： Astrazeneca AB
发明人： BERGLUND, Susanne, Elisabeth , CONNOLLY, Stephen , HEMMERLING, Martin , HOSSAIN, Nafizal , KRISTOFFERSSON, Anna , LUNDKVIST, Johan, Rune, Michael , NIKITIDIS, Grigorios , RIPA, Lena, Elisabeth , SHAMOVSKY, Igor
IPC分类号： C07D401/06 , C07D241/28 , A61K31/497 , A61P11/00
CPC分类号： C07D401/12 , A61K31/4965 , A61K31/497 , A61K45/06 , C07D241/26 , C07D241/28 , C07D401/06
摘要： The present invention provides a compound of a formula (I): or a pharmaceutically acceptable salt thereof; a process for preparing such a compound; and to the use of such a compound in the treatment of an ENaC mediated disease state (such as asthma, CF or COPD).
摘要翻译： 本发明提供式（I）的化合物或其药学上可接受的盐; 制备这种化合物的方法; 以及在治疗ENaC介导的疾病状态（例如哮喘，CF或COPD）中使用这种化合物。
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9.发明公开
公开(公告)号：EP2097384A1
公开(公告)日：2009-09-09
申请号：EP07835228.3
申请日：2007-11-22
发明人： BERGER, Markus , BERGSTRÖM, Lena , DAHMÉN, Jan , ERIKSSON, Anders , GABOS, Balint , HEMMERLING, Martin , HENRIKSSON, Krister , IVANOVA, Svetlana , LEPISTÖ, Matti , MCKERRECHER, Darren , NILSSON, Stinabritt , REHWINKEL, Hartmut , TAFLIN, Camilla
IPC分类号： C07D231/56 , A61K31/416 , A61K31/454 , A61K31/4545 , A61P11/00 , A61P29/00 , A61P35/00 , A61P37/06 , A61P37/08 , C07D401/04 , C07D401/14
CPC分类号： C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Compounds of formula (I) or a pharmaceutically acceptable salt thereof; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating the glucocorticoid receptor in a warm blooded animal).
摘要翻译： 式（I）化合物或其药学上可接受的盐; 包含它们的组合物，制备它们的方法以及它们在医学治疗中的用途（例如调节温血动物中的糖皮质激素受体）。
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10.发明公开NOVEL 1 -BENZYL-4-PIPERIDINAMINES THAT ARE USEFUL IN THE TREATMENT OF COPD AND ASTHMA 审中-公开NEW FOR治疗哮喘和COPD的适当的1-苄基-4-哌啶
公开(公告)号：EP1945613A1
公开(公告)日：2008-07-23
申请号：EP06812951.9
申请日：2006-10-31
申请人： AstraZeneca AB
发明人： HEMMERLING, Martin , HOSSAIN, Nafizal , IVANOVA, Svetlana , MUSSIE, Tesfaledet , SHAMOVSKY, Igor , SJÖHOLM Timèn, Åsa
IPC分类号： C07D211/58 , A61K31/4468 , A61K31/454 , A61P11/00 , A61P11/06 , C07D401/12
CPC分类号： C07D211/58 , C07D211/72 , C07D401/12
摘要： The invention provides 1 -benzyl- 4 -piperidinamines of the general formula (I), processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are useful in the treatment of respiratory diseses such as chronic obstructive pulmonary disease and asthma. The compounds are inhibitors of the CCRl receptor.
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