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1.发明公开ISOQUINOLINONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE ( COPD ) AND ASTHMA 有权ISOQUINOLINDERIVATE，其制造方法和它们在治疗哮喘和慢性阻塞性肺疾病的治疗
公开(公告)号：EP2144881A1
公开(公告)日：2010-01-20
申请号：EP08718978.3
申请日：2008-04-04
申请人： AstraZeneca AB
发明人： HALLAM, Matthew , MARTIN, Barrie , RAUBO, Piotr , ROBERTS, Bryan , ST-GALLAY, Stephen , WILLIS, Paul
IPC分类号： C07D217/24 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D487/08 , A61K31/4353 , A61P11/06
CPC分类号： C07D217/24 , C07D217/26 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D487/08
摘要： The present invention relates to isoquinolinone derivatives of formula (I): should be wherein R1, R2, R3, R4, R5, R6 and R7 are as herein defined; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
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2.发明授权N-PYRAZINYL-PHENYLSULPHONAMIDES AND THEIR USE IN THE TREATMENT OF CHEMOKINE MEDIATED DISEASES 有权N-吡嗪phenylsulfonamides及其用于疾病治疗的介导的趋化因子
公开(公告)号：EP1467976B1
公开(公告)日：2011-11-23
申请号：EP03700655.8
申请日：2003-01-14
申请人： AstraZeneca AB
IPC分类号： C07D241/22 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/12 , A61K31/4965 , A61P11/06 , A61P29/00
CPC分类号： C07D231/12 , C07D233/56 , C07D241/22 , C07D249/08 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07F7/0812
摘要： The invention provides N-pyrazinyl-phenylsulphonamides of formula (I) for use in the treatment of chemokine mediated diseases. Particularly inflammatory diseases, such as asthma.
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公开(公告)号：EP1109790B1
公开(公告)日：2003-05-14
申请号：EP99946526.3
申请日：1999-08-27
申请人： AstraZeneca AB
发明人： BAXTER, Andrew , BENNION, Colin , CAGE, Peter , KINDON, Nicholas , MORTIMORE, Michael , ROBERTS, Bryan
IPC分类号： C07D249/12 , C07D401/04 , C07D405/04 , C07D409/04 , A61K31/4196
CPC分类号： C07D401/04 , C07D249/12 , C07D403/04 , C07D405/04 , C07D409/04
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公开(公告)号：EP1109790A1
公开(公告)日：2001-06-27
申请号：EP99946526.3
申请日：1999-08-27
申请人： AstraZeneca AB
发明人： BAXTER, Andrew , BENNION, Colin , CAGE, Peter , KINDON, Nicholas , MORTIMORE, Michael , ROBERTS, Bryan
IPC分类号： C07D249/12 , C07D401/04 , C07D405/04 , C07D409/04 , A61K31/4196
CPC分类号： C07D401/04 , C07D249/12 , C07D403/04 , C07D405/04 , C07D409/04
摘要： The invention provides certain 1,2,4-triazole-3-thione compounds, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
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5.发明授权ISOQUINOLINONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE ( COPD ) AND ASTHMA 有权ISOQUINOLINDERIVATE，其制造方法和它们在治疗哮喘和慢性阻塞性肺疾病的治疗
公开(公告)号：EP2144881B1
公开(公告)日：2012-06-20
申请号：EP08718978.3
申请日：2008-04-04
申请人： AstraZeneca AB
发明人： HALLAM, Matthew , MARTIN, Barrie , RAUBO, Piotr , ROBERTS, Bryan , ST-GALLAY, Stephen , WILLIS, Paul
IPC分类号： C07D217/24 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D487/08 , A61K31/4353 , A61P11/06
CPC分类号： C07D217/24 , C07D217/26 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D487/08
摘要： The present invention relates to isoquinolinone derivatives of formula (I): should be wherein R1, R2, R3, R4, R5, R6 and R7 are as herein defined; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
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6.发明授权NOVEL N-(FLUORO-PYRAZINYL)-PHENYLSULFONAMID.ES AS MOODULATORS OF CHEMOKINE RECEPTOR CCR4. 有权NEW N-（FLUORPYRAZINYL）phenylsulfonamides AS趋化因子受体CCR4的调节剂
公开(公告)号：EP1968951B1
公开(公告)日：2011-06-22
申请号：EP06835834.0
申请日：2006-12-11
申请人： AstraZeneca AB
IPC分类号： C07D241/22 , A61K31/4965 , A61P11/00 , A61P11/06
CPC分类号： C07D241/22
摘要： The invention provides N-(fluoro-pyrazinyl)-phenylsulfonamides of formula (I) wherein R1 -R5 are as defined in the specification; processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy
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7.发明公开NOVEL N-(FLUORO-PYRAZINYL)-PHENYLSULFONAMID.ES AS MOODULATORS OF CHEMOKINE RECEPTOR CCR4. 有权新颖的N-（氟 - 吡嗪基） - 苯基磺酰胺作为趋化因子受体CCR4的调节剂。
公开(公告)号：EP1968951A1
公开(公告)日：2008-09-17
申请号：EP06835834.0
申请日：2006-12-11
申请人： AstraZeneca AB
IPC分类号： C07D241/22 , A61K31/4965 , A61P11/00 , A61P11/06
CPC分类号： C07D241/22
摘要： The invention provides N-(fluoro-pyrazinyl)-phenylsulfonamides of formula (I) wherein R1 -R5 are as defined in the specification; processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy
摘要翻译： 本发明提供式（I）的N-（氟 - 吡嗪基） - 苯基磺酰胺，其中R 1 -R 5如说明书中所定义; 在其制备中使用的方法和中间体，含有它们的药物组合物以及它们在治疗中的用途
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