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1.发明授权
公开(公告)号：EP1761517B1
公开(公告)日：2014-09-24
申请号：EP05758460.9
申请日：2005-06-18
IPC分类号： C07D401/04 , A61K31/4196 , A61P3/10
CPC分类号： C07D471/04 , C07D249/14 , C07D401/04 , C07D401/12 , C07D401/14
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2.发明授权8-[3-AMINO-PIPERIDIN-1-YL] -XANTHINE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 有权8- [3-氨基 - 哌啶-1-基] -xanthines，其制备方法及其作为药物的用途
公开(公告)号：EP1532149B1
公开(公告)日：2009-12-30
申请号：EP03792359.6
申请日：2003-08-18
发明人： HIMMELSBACH, Frank , LANGKOPF, Elke , ECKHARDT, Matthias , MARK, Michael , MAIER, Roland , LOTZ, Ralf, Richard, Hermann , TADAYYON, Mohammad
IPC分类号： C07D473/04 , A61K31/522 , A61P3/10
CPC分类号： A61K9/2866 , A61K9/0095 , A61K9/02 , A61K9/2018 , A61K9/4858 , A61K47/02 , C07D473/04
摘要： The invention relates to substituted xanthines of general formula (I) wherein R1 to R3 have the designations cited in patent claims 1 to 16, and to the tautomers, stereoisomers, mixtures, prodrugs and salts thereof, which have precious pharmacological properties, especially an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
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3.发明授权GLUCOPYRANOSYL-SUBSTITUTED ((HETERO)ARYLETHYNYL-BENZYL)-BENZENE DERIVATIVES AND USE THEREOF AS SODIUM-DEPENDENT GLUCOSE COTRANSPORTER 2 (SGLT2) INHIBITORS 有权GLUCOPYRANOSYLSUBSTITUIERTE（（杂）芳基乙炔 - 苄基）-BENZENDERIVATIVE及其作为钠依赖性葡萄糖协同转运蛋白2型抑制剂（SGLT2）
公开(公告)号：EP1856082B1
公开(公告)日：2009-10-14
申请号：EP06708381.6
申请日：2006-02-20
发明人： HIMMELSBACH, Frank , ECKHARDT, Matthias , EICKELMANN, Peter , THOMAS, Leo , BARSOUMIAN, Edward Leon
IPC分类号： C07D309/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/10 , A61K31/351 , A61K31/381 , A61K31/41 , A61K31/4155 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/443 , A61K31/506 , A61K31/501
CPC分类号： C07D309/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/10
摘要： Glucopyranosyl-substituted (hetero)arylethynyl-benzene derivatives of the general formula (I) where the groups R1 to R6 as well as R7a, R7b, R7c are defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are SGLT2 inhibitors suitable for the treatment of metabolic disorders.
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4.发明公开GLUCOPYRANOSYL-SUBSTITUTED BENZYL-BENZONITRILE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR MANUFACTURE 审中-公开GLUCOPYRANOSYLSUBSTITUIERTE BENZYLBENZONITRILDERIVATE，药物，这些化合物，它们的用途和工艺及其
公开(公告)号：EP2079753A1
公开(公告)日：2009-07-22
申请号：EP07822206.4
申请日：2007-11-05
IPC分类号： C07H7/04 , C07D309/10 , A61K31/70
CPC分类号： C07H7/04 , A61K9/0019 , A61K9/02 , A61K9/2018 , A61K9/4866 , A61K47/02
摘要： Glucopyranosyl-substituted benzyl-benzonitrile derivatives of general formula (I) as defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.
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5.发明公开GLUCOPYRANOSYL-SUBSTITUTED BENZONITRILE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR MANUFACTURE 有权吡喃葡萄糖基取代苯甲腈衍生物，这样的化合物的药物组合物，它们的使用及其制造方法
公开(公告)号：EP2024352A1
公开(公告)日：2009-02-18
申请号：EP07728702.7
申请日：2007-05-02
IPC分类号： C07D309/10 , A61K31/351
CPC分类号： C07H7/04 , A61K9/0019 , A61K9/02 , A61K9/2018 , A61K9/4866 , C07D309/10
摘要： Glucopyranosyl- substituted, benzonitrile derivatives defined according to formula I, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof . The compounds according to the invention are suitable for the treatment of metabolic disorders. formula (I), wherein R3 denotes hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, propyl, \ isopropyl, butyl, sec-butyl, iso-butyl, tert-butyl, 3-methyl-but-1-yl, cyclopropyl, \ cyclobutyl, cyclopentyl, cyclohexyl, 1-hydroxy-cyclopropyl, 1-hydroxy-cyclobutyl, 1- hydroxy-cyclopentyl, 1 -hydroxy-cyclohexyl, difluoromethyl, trifluoromethyl, pentafluoroethyl,_2-hydroxyl-ethyl, hydroxymethyl, 3-hydroxy-propyl, 2-hydroxy-2- methyl-prop-1-yl, 3-hydroxy-3-methyl-but-1-yl, 1-hydroxy-1 -methyl-ethyl, 2,2,2- trifluoro-1-hydroxy-1 -methyl-ethyl, 2,2,2-trifluoro-i-hydroxy-i-trifluoromethyl-ethyl, 2- methoxy-ethyl, 2-ethoxy-ethyl, hydroxy, difiuoromethyloxy, trifluoromethyloxy, 2- methyloxy-ethyloxy, methylsulfanyl, methylsulfinyl, methlysulfonyl, ethylsulfinyl, ethylsulfonyl, trimethylsilyl or cyano,
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公开(公告)号：EP1641799B8
公开(公告)日：2008-10-08
申请号：EP04736644.8
申请日：2004-06-11
发明人： ECKHARDT, Matthias , HAUEL, Norbert , LANGKOPF, Elke , HIMMELSBACH, Frank , KAUFFMANN-HEFNER, Iris , TADAYYON, Mohammad , MARK, Michael
IPC分类号： C07D487/04 , C07D471/04 , C07D519/00 , A61K31/5025 , A61P3/10
CPC分类号： C07D471/04 , C07D487/04
摘要： The invention relates to substituted imidazo-pyridinones and imidazo-pyridazinones of general formula (I), wherein Y and R1 to R4 are defined as indicated in claim 1, the tautomers, enantiomers, diastereomers, mixtures, and salts thereof that have valuable pharmacological properties, especially an inhibiting effect on the activity of the dipeptidyl peptidase IV (DPP-IV) enzyme.
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7.发明公开GLUCOPYRANOSYL-SUBSTITUTED BENZYL-BENZENE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR MANUFACTURE 有权吡喃葡萄糖基取代苄基衍生物，这样的化合物，它们的用途和工艺制毒化
公开(公告)号：EP1924571A2
公开(公告)日：2008-05-28
申请号：EP06778367.0
申请日：2006-08-28
IPC分类号： C07D309/10 , C07H7/04 , A61K31/351
CPC分类号： C07D309/10 , C07D407/12
摘要： Glucopyranosyl-substituted benzyl-benzene derivatives of the general formula (I) where the groups R1 to R6 as well as R7a, R7b, R7c are defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The Compounds according to the invention are suitable for the treatment of metabolic disorders.
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8.发明公开GLUCOPYRANOSYL-SUBSTITUTED BENZENE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR MANUFACTURE 有权吡喃葡萄糖基取代苯的衍生物，这样的化合物，它们的用途和工艺制毒化
公开(公告)号：EP1828216A2
公开(公告)日：2007-09-05
申请号：EP05821489.1
申请日：2005-12-15
发明人： ECKHARDT, Matthias , HIMMELSBACH, Frank , EICKELMANN, Peter , BARSOUMIAN, Edward Leon , THOMAS, Leo
IPC分类号： C07H7/04 , A61K31/7042
CPC分类号： C07H7/04
摘要： Glucopyranosyl-substituted benzene derivatives defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.
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9.发明公开8-(3-AMINO-PIPERIDIN-1-YL)-7-(BUT-2-INYL)-XANTHINE, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL 审中-公开8-（3-氨基 - 哌啶-1-基）-7-（丁-2-炔基）-xanthines，其制备方法及其作为药物的用途
公开(公告)号：EP1791844A1
公开(公告)日：2007-06-06
申请号：EP05790339.5
申请日：2005-09-06
IPC分类号： C07D473/04 , A61K31/437 , A61P3/10
CPC分类号： C07D473/06 , C07D473/04
摘要： The invention relates to substituted xanthines of general formula (I), wherein R1 and R2 have the meaning cited in claims 1 to 11. The invention also relates to the tautomers, enantiomers, diastereomers, mixtures and salts thereof, which have valuable pharmacological properties, especially an inhibiting action on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
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10.发明授权
公开(公告)号：EP1554278B1
公开(公告)日：2006-04-12
申请号：EP03792342.2
申请日：2003-08-16
发明人： ECKHARDT, Matthias , MARK, Michael , HIMMELSBACH, Frank , LANGKOPF, Elke , LOTZ, Ralf , MAIER, Roland
IPC分类号： C07D473/00
CPC分类号： C07D473/04 , C07D473/06
摘要： The invention concerns substituted xanthines of general formula (I), wherein: R1 to R4 are such as defined in Claim 1, and tautomers, stereoisomers, mixtures, prodrugs and salts thereof. Said compounds have advantageous pharmacological properties, in particular an inhibiting effect on the activity of the dipeptidyl peptidase IV (DPP-IV) enzyme.
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