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公开(公告)号：EP1343786A1
公开(公告)日：2003-09-17
申请号：EP01997489.8
申请日：2001-11-09
发明人： STASCH, Johannes-Peter , FEURER, Achim , WEIGAND, Stefan , STAHL, Elke , FLUBACHER, Dietmar , ALONSO-ALIJA, Cristina , WUNDER, Frank , LANG, Dieter , DEMBOWSKY, Klaus , STRAUB, Alexander , PERZBORN, Elisabeth
IPC分类号： C07D471/04 , A61K31/415 , A61P9/00
CPC分类号： C07D471/04 , A61K31/505 , A61K45/06 , A61K2300/00
摘要： The invention relates to novel pyrazolopyridine derivatives of the formula (I), wherein R1 represents 4-pyridinyl or 3-pyridinyl; R2 represents H, NH¿2? or halogen, and to the salts, isomers and hydrates thereof as stimulators of the soluble guanylate cyclase and for the use as agents for treating cardiovascular diseases, hypertonia, thromboembolic diseases and ischemias, sexual dysfunction or inflammations and for treating diseases of the central nervous system.
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公开(公告)号：EP1339716A1
公开(公告)日：2003-09-03
申请号：EP01997487.2
申请日：2001-11-09
发明人： STASCH, Johannes-Peter , FEURER, Achim , WEIGAND, Stefan , STAHL, Elke , FLUBACHER, Dietmar , ALONSO-ALIJA, Cristina , WUNDER, Frank , LANG, Dieter , DEMBOWSKY, Klaus , STRAUB, Alexander , PERZBORN, Elisabeth
IPC分类号： C07D471/04 , A61K31/437 , A61P9/00 , A61P15/00 , A61P25/00
CPC分类号： C07D471/04
摘要： The invention relates to novel pyrazolopyridine derivatives of formula (I) wherein R1 represents NH¿2? or NHCO-C1-6-alkyl, and R?2¿ represents a radical of formula R3NCOR4 which is bonded to the radical of the molecule by means of the nitrogen atom, R?3 and R4¿ forming, together with the amide group to which they are bonded, a five to six-membered heterocycle which can be saturated or partially unsaturated, can optionally contain another heteroatom from the group N, O, S and can comprise between one and five other substituents from the group oxo, C1-6 alkyl, hydroxy, hydroxy-C¿1-6?-alkyl, halogen, or can be anellated to a C6-10 aryl ring or a C3-8 cycloalkyl ring in which optionally two carbon atoms are bonded to each other by means of an oxygen atom. The invention also relates to salts, isomers and hydrates of said derivatives, in the form of stimulators of soluble guanylate cyclase and as agents for treating cardiovascular diseases, hypertonia, thrombo-embolic diseases and ischaemia, sexual dysfunction, inflammations, and diseases of the central nervous system.
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公开(公告)号：EP1339714A1
公开(公告)日：2003-09-03
申请号：EP01989460.9
申请日：2001-11-12
发明人： STASCH, Johannes-Peter , FEURER, Achim , WEIGAND, Stefan , STAHL, Elke , FLUBACHER, Dietmar , ALONSO-ALIJA, Cristina , WUNDER, Frank , LANG, Dieter , DEMBOWSKY, Klaus , STRAUB, Alexander , PERZBORN, Elisabeth
IPC分类号： C07D471/04 , A61K31/437 , A61P9/00 , A61P15/00
CPC分类号： C07D471/04
摘要： The invention relates to novel pyrazolopyridine derivatives of formula (I) wherein R1 represents H, Cl or NH¿2?, and R?2 and R3¿ form, together with the heteroatoms to which they are bonded, a five to six-membered heterocycle which can be saturated or partially unsaturated, can optionally contain at least one other heteroatom from the group N, O, S and can be optionally substituted. The invention also relates to salts, isomers and hydrates of said derivatives, in the form of stimulators of soluble guanylate cyclase and as agents for treating cardiovascular diseases, hypertonia, thrombo-embolic diseases and ischaemia, sexual dysfunction, inflammations, and diseases of the central nervous system.
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4.发明公开NEUARTIGE DICARBONSÄUREDERIVATE MIT PHARMAZEUTISCHEN EIGENSCHAFTEN 有权NEUARTIGEDICARBONSÄUREDERIVATEMIT PHARMAZUUTISCHEN EIGENSCHAFTEN
公开(公告)号：EP1216223A1
公开(公告)日：2002-06-26
申请号：EP00964067.3
申请日：2000-08-31
发明人： ALONSO-ALIJA, Cristina , HEIL, Markus , FLUBACHER, Dietmar , NAAB, Paul , STASCH, Johannes-Peter , WUNDER, Frank , DEMBOWSKY, Klaus , PERZBORN, Elisabeth , STAHL, Elke
IPC分类号： C07C69/94 , C07C69/76 , C07C65/28 , C07C63/33 , C07C63/72 , C07C65/24 , C07C69/92 , C07D241/04 , C07C323/62 , C07C323/56 , C07C317/46 , C07C229/52 , C07C229/38 , C07D213/64 , C07C235/84
CPC分类号： C07D213/64 , C07C63/33 , C07C63/72 , C07C65/24 , C07C65/28 , C07C69/76 , C07C69/92 , C07C69/94 , C07C217/22 , C07C229/38 , C07C229/52 , C07C233/25 , C07C235/42 , C07C275/42 , C07C323/56 , C07C323/62 , C07D211/60 , C07D213/65 , C07D231/12 , C07D233/90 , C07D261/08 , C07D263/57 , C07D271/06 , C07D277/24 , C07D295/088 , C07D295/185 , C07D295/21 , C07D307/42 , C07D333/54
摘要： The invention relates to the use of compounds of formula (I) and of their salts and stereoisomers in the production of medicaments for treating cardiovascular diseases.
摘要翻译： 本发明涉及式（I）化合物及其盐和立体异构体在制备用于治疗心血管疾病的药物中的用途。
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公开(公告)号：EP1339717A1
公开(公告)日：2003-09-03
申请号：EP01997488.0
申请日：2001-11-09
发明人： STASCH, Johannes-Peter , FEURER, Achim , WEIGAND, Stefan , STAHL, Elke , FLUBACHER, Dietmar , ALONSO-ALIJA, Cristina , WUNDER, Frank , LANG, Dieter , DEMBOWSKY, Klaus , STRAUB, Alexander , PERZBORN, Elisabeth
IPC分类号： C07D471/04 , A61K31/437 , A61P9/00 , A61P15/00
CPC分类号： C07D471/04
摘要： The invention relates to novel pyrazolopyridine derivatives of the formula (I), wherein R1 represents hydrogen or a di-C¿1-6?-alkylaminocarbonyl group, R?2¿ represents a rest of the formula -O-CO-NR3R4, wherein R?3 and R4¿ are the same or different and represent a rest of the group comprising optionally substituted C¿1-6 ?alkyl, optionally substituted C2-6 alkenyl, or optionally substituted C3-8 cycloalkyl; or which, together with the nitrogen atom to which they are bound, form a five- to seven-membered saturated heterocycle that may optionally contain an additional hetero atom from the group N, O, S and/or that may be optionally substituted, and to the salts, isomers and hydrates of said derivatives, as stimulants of the soluble guanylate cyclase and for use as agents for treating cardiovascular diseases, hypertonia, thromboembolic diseases and ischemia, sexual dysfunction or inflammations, and for treating diseases of the central nervous system.
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公开(公告)号：EP1216222A2
公开(公告)日：2002-06-26
申请号：EP00962413.1
申请日：2000-08-31
发明人： ALONSO-ALIJA, Cristina , HEIL, Markus , FLUBACHER, Dietmar , NAAB, Paul , STASCH, Johannes-Peter , WUNDER, Frank , DEMBOWSKY, Klaus , PERZBORN, Elisabeth , STAHL, Elke
IPC分类号： C07C69/76 , C07C69/34 , C07C69/738 , C07C69/734 , C07C69/94 , C07C255/57 , C07C309/73 , C07C323/62 , C07C65/28 , C07C63/66 , C07C65/24 , C07C63/331 , C07F9/54 , A61K31/194 , A61K31/235 , A61K31/277 , A61K31/66 , A61P9/00
CPC分类号： C07C69/92 , C07C65/24 , C07C65/28 , C07C69/94 , C07C255/57 , C07C323/62 , C07F9/4006
摘要： The invention relates to compounds of formula (I) as well as the salts and stereoisomers thereof used to produce medicaments for the treatment of cardiovascular diseases.
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7.发明公开PYRROLO (2.1-A) DIHYDROISOQUINOLINES AND THEIR USE AS PHOSPHODIESTERASE 10A INHIBITORS 审中-公开吡咯（2.1）二氢异喹啉及其作为磷酸二酯酶抑制剂10A
公开(公告)号：EP1347973A1
公开(公告)日：2003-10-01
申请号：EP01989571.3
申请日：2001-12-04
发明人： NIEWÖHNER, Ulrich , BAUSER, Marcus , ERGÜDEN, Jens-Kerim , FLUBACHER, Dietmar , NAAB, Paul , REPP, Thorsten-Oliver , STOLTEFUSS, Jürgen , BURKHARDT, Nils , SEWING, Andrea , SCHAUER, Michael , SCHLEMMER, Karl-Heinz , WEBER, Olaf , BOYER, Stephen, J. , MIGLARESE, Mark , Niewöhner, Maria Theresia
IPC分类号： C07D471/04 , A61K31/4745 , A61P35/00
CPC分类号： C07D471/04
摘要： The present invention relates to pyrrolo[2.1-a]dihydroisoquinolines which are inhibitors of phosphodiesterase 10a and can be used for combating cancer.
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8.发明公开NEUARTIGE AMINODICARBONSÄUREDERIVATE MIT PHARMAZEUTISCHEN EIGENSCHAFTEN 有权与制药特性的新AMINODICARBONSÄUREDERIVATE
公开(公告)号：EP1216225A2
公开(公告)日：2002-06-26
申请号：EP00958516.7
申请日：2000-08-31
发明人： ALONSO-ALIJA, Cristina , HEIL, Markus , FLUBACHER, Dietmar , NAAB, Paul , PERNERSTORFER, Josef , STASCH, Johannes-Peter , WUNDER, Frank , DEMBOWSKY, Klaus , PERZBORN, Elisabeth , STAHL, Elke
IPC分类号： C07C229/38 , C07D239/30 , C07D277/24 , C07D271/04 , C07D285/06 , A61K31/195 , A61K31/24 , A61K31/505 , A61K31/426 , A61K31/33
CPC分类号： C07D239/30 , C07C229/38 , C07C233/25 , C07C235/56 , C07C237/12 , C07C255/54 , C07C275/24 , C07C317/18 , C07C323/19 , C07C2601/14 , C07C2602/10 , C07D239/38 , C07D271/06 , C07D277/24 , C07D285/06 , C07D295/088 , C07D333/16
摘要： The invention relates to compounds of formula (I) as well as the salts and stereoisomers thereof used in the production of medicaments for the treatment of cardiovascular diseases.
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