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公开(公告)号：EP3402789B1
公开(公告)日：2020-03-18
申请号：EP17701778.7
申请日：2017-01-12
发明人： BOSANAC, Todd , BENTZIEN, Joerg , BURKE, Michael Jason , DISALVO, Darren Todd , MAO, Wang , SOLEYMANZADEH, Fariba , WESTBROOK, John , XIONG, Zhaoming
IPC分类号： C07D401/14 , C07D401/04 , C07D401/06 , C07D401/10 , C07D471/04 , A61K31/4725 , A61K31/506 , A61P19/00 , A61P37/00
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公开(公告)号：EP3099674B1
公开(公告)日：2018-10-24
申请号：EP15704880.2
申请日：2015-01-23
发明人： BENTZIEN, Joerg , BERRY, Angela , BOSANAC, Todd , BURKE, Michael, J. , DISALVO, Darren , MAO, Can , MAO, Wang , SHEN, Yue
IPC分类号： C07D403/10 , C07D401/10 , A61K31/4155 , A61K31/454 , A61P19/02 , A61P29/00
CPC分类号： C07D403/04 , C07D401/04 , C07D401/10 , C07D403/10
摘要： The present invention encompasses compounds of the formula (I) wherein the groups R1, Cy, and Y are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.
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公开(公告)号：EP2766360A1
公开(公告)日：2014-08-20
申请号：EP12762428.6
申请日：2012-08-09
发明人： BERRY, Angela , BOSANAC, Todd , GINN, John David , HOPKINS, Tamara Denise , SCHLYER, Sabine , SOLEYMANZADEH, Fariba , WESTBROOK, John , YU, Maolin , ZHANG, Zhonghua
IPC分类号： C07D417/12 , C07D417/14 , A61K31/427 , A61P25/00
CPC分类号： C07D417/14 , C07D417/04 , C07D417/12
摘要： The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein R
1 - R
5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1 -R 5和n如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和用于这些方法的中间体。
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4.发明授权GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF 有权GLUCOCORTICOIDMIMETIKA，用于生产药物组合物的方法及其用途
公开(公告)号：EP2300472B1
公开(公告)日：2012-01-18
申请号：EP09759298.4
申请日：2009-06-03
发明人： BOEHRINGER INGELHEIM PHARMA GMBH&CO. KG , BETAGERI, Rajashekhar , BOSANAC, Todd , BURKE, Michael, Jason , HARCKEN, Christian , KIM, Soojin , KUZMICH, Daniel , LEE, Thomas, Wai-ho , LI, Zhibin , LIU, Pingrong , LORD, John , RAZAVI, Hossein , REEVES, Jonathan, Timothy , THOMSON, David
IPC分类号： C07D471/04 , A61K31/437 , A61P5/44 , A61P5/46
CPC分类号： C07D471/04
摘要： Compounds of Formula I wherein R
1 , R
2 , X, and Y are as defined herein, or a tautomer, optical isomer, prodrug, co-crystal, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.-
公开(公告)号：EP3390390A2
公开(公告)日：2018-10-24
申请号：EP16867378.8
申请日：2016-12-15
发明人： BOSANAC, Todd , BENTZIEN, Joerg , BURKE, Michael Jason , FRYER, Ryan Michael , LARSON, Eric Thomas , MAO, Wang , MCKIBBEN, Bryan Patrick , SHEN, Yue , SOLEYMANZADEH, Fariba , TSCHANTZ, Matt Aaron
IPC分类号： C07D401/14 , C07D403/14 , A61K31/4155 , A61K31/4439 , A61P37/06
CPC分类号： C07D403/14 , C07D401/14
摘要： wherein the groups R1, Cy and Y are defined herein, which are suitable for the treatment of diseases related to BTK, and processes for making these compounds, pharmaceutical preparations containing these compounds, and their methods of use.
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公开(公告)号：EP2331541B1
公开(公告)日：2015-04-22
申请号：EP09791866.8
申请日：2009-08-25
IPC分类号： C07D471/04 , A61K31/437 , A61P9/10 , A61P29/00 , A61P37/00
CPC分类号： C07D471/04
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公开(公告)号：EP2619197A1
公开(公告)日：2013-07-31
申请号：EP11761775.3
申请日：2011-09-20
发明人： BARTOLOZZI, Alessandra , BOSANAC, Todd , CHEN, Zhidong , DE LOMBAERT, Stéphane , DINES, Jonathon, Alan , HUBER, John, D. , LIU, Weimin , LOKE, Pui Leng , MORWICK, Tina, Marie , OLAGUE, Alan , RIETHER, Doris , TYE, Heather , WU, Lifen , ZINDELL, Renee, M.
IPC分类号： C07D413/14 , A61K31/497 , A61P11/00
CPC分类号： C07D413/14
摘要： The present invention relates to compounds of formula (I) and (IA) and pharmaceutically acceptable salts thereof, wherein R
1 - R
5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.摘要翻译： 本发明涉及式（I）和（IA）的化合物及其药学上可接受的盐，其中R 1 -R 5如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和用于这些方法的中间体。
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公开(公告)号：EP2766360B1
公开(公告)日：2017-07-12
申请号：EP12762428.6
申请日：2012-08-09
发明人： BERRY, Angela , BOSANAC, Todd , GINN, John David , HOPKINS, Tamara Denise , SCHLYER, Sabine , SOLEYMANZADEH, Fariba , WESTBROOK, John , YU, Maolin , ZHANG, Zhonghua
IPC分类号： C07D417/12 , C07D417/14 , A61K31/427 , A61P25/00
CPC分类号： C07D417/14 , C07D417/04 , C07D417/12
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9.发明公开HETEROAROMATIC COMPOUNDS AS BRUTON'S TYROSINE KINASE (BTK) INHIBITORS 审中-公开杂芳族化合物ALS布鲁顿酪氨酸激酶（BTK）抑制剂
公开(公告)号：EP2882741A1
公开(公告)日：2015-06-17
申请号：EP13752756.0
申请日：2013-08-08
发明人： BENTZIEN, Joerg Martin , BERRY, Angela Kay , BOSANAC, Todd , BURKE, Michael, Jason , DISALVO, Darren, Todd , HORAN, Joshua, Courtney , LIANG, Shuang , MAO, Can , MAO, Wang , SHEN, Yue , SOLEYMANZADEH, Fariba , ZINDELL, Renee, M.
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D231/38 , C07D401/04 , C07D401/06 , C07D403/02 , C07D403/06 , C07D417/02 , C07D417/04 , C07D417/06 , C07D277/56 , C07D403/04 , A61P19/00 , A61P11/00
CPC分类号： C07D417/08 , C07D231/14 , C07D231/38 , C07D231/40 , C07D277/56 , C07D401/02 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D405/14 , C07D413/14 , C07D417/02 , C07D417/04 , C07D417/06
摘要： wherein the groups A, Cy, X1 and Y are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.
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公开(公告)号：EP2606045A1
公开(公告)日：2013-06-26
申请号：EP11748842.9
申请日：2011-08-11
发明人： BARTOLOZZI, Alessandra , BOSANAC, Todd , CHEN, Zhidong , DE LOMBAERT, Stephane , HUBER, John, D. , LO, Ho Yin , LOKE, Pui Leng , LIU, Weimin , MORWICK, Tina Marie , OLAGUE, Alan , RIETHER, Doris , TYE, Heather , WU, Lifen , ZINDELL, Renee
IPC分类号： C07D413/10 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/04 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/4985 , A61K31/506 , A61K31/5365 , A61K31/5377 , A61K31/541 , A61P9/00 , A61P9/10 , A61P29/00 , A61P37/08 , A61P11/00
CPC分类号： C07D413/14 , C07D413/10 , C07D417/14 , C07D471/04 , C07D498/04
摘要： The present invention relates to compound of formula (I): or pharmaceutically acceptable salts thereof, wherein R
1 -R
5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中R 1 -R 5如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和用于这些方法的中间体。
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