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公开(公告)号：EP2651930B1
公开(公告)日：2015-10-28
申请号：EP11808438.3
申请日：2011-12-14
发明人： BERRY, Angela , CHEN, Zhidong , DE LOMBAERT, Stephane , EMMANUEL, Michel Jose , LOKE, Pui Leng , MAN, Chuk Chui , MORWICK, Tina Marie , TAKAHASHI, Hidenori
IPC分类号： C07D405/10 , C07D405/12 , C07D405/14 , C07D417/12 , C07D417/14 , C07D413/12 , C07D413/14 , C07D409/14 , C07D403/12 , C07D403/04 , C07D403/14 , C07D239/42 , A61K31/506 , A61K31/473 , A61K31/444
CPC分类号： C07D405/10 , C07D239/42 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
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公开(公告)号：EP2651930A1
公开(公告)日：2013-10-23
申请号：EP11808438.3
申请日：2011-12-14
发明人： BERRY, Angela , CHEN, Zhidong , DE LOMBAERT, Stephane , EMMANUEL, Michel Jose , LOKE, Pui Leng , MAN, Chuk Chui , MORWICK, Tina Marie , TAKAHASHI, Hidenori
IPC分类号： C07D405/10 , C07D405/12 , C07D405/14 , C07D417/12 , C07D417/14 , C07D413/12 , C07D413/14 , C07D409/14 , C07D403/12 , C07D403/04 , C07D403/14 , C07D239/42 , A61K31/506 , A61K31/473 , A61K31/444
CPC分类号： C07D405/10 , C07D239/42 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, C, R
1a , R
1b , R
2 , R
3 , R
4a and R
4b are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中A，B，C，R 1a，R 1b，R 2，R 3，R 4a和R 4b如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和用于这些方法的中间体。
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公开(公告)号：EP2398771A2
公开(公告)日：2011-12-28
申请号：EP10704712.8
申请日：2010-02-16
发明人： BARTOLOZZI, Alessandra , BERRY, Angela , CIRILLO, Pier Francesco , HICKEY, Eugene Richard , RIETHER, Doris , WU, Lifen , ZINDELL, Renee M.
IPC分类号： C07D211/60 , C07D401/12 , C07D405/04 , C07D413/12 , C07D417/12 , C07D417/14 , A61K31/4545 , A61P25/04
CPC分类号： C07D413/12 , C07D211/60 , C07D401/12 , C07D405/04 , C07D417/12 , C07D417/14
摘要： Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
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公开(公告)号：EP2766360B1
公开(公告)日：2017-07-12
申请号：EP12762428.6
申请日：2012-08-09
发明人： BERRY, Angela , BOSANAC, Todd , GINN, John David , HOPKINS, Tamara Denise , SCHLYER, Sabine , SOLEYMANZADEH, Fariba , WESTBROOK, John , YU, Maolin , ZHANG, Zhonghua
IPC分类号： C07D417/12 , C07D417/14 , A61K31/427 , A61P25/00
CPC分类号： C07D417/14 , C07D417/04 , C07D417/12
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公开(公告)号：EP2384320B1
公开(公告)日：2015-03-04
申请号：EP09775474.1
申请日：2009-12-15
发明人： BERRY, Angela , BETAGERI, Rajashekhar , RIETHER, Doris , HICKEY, Eugene Richard , WU, Lifen , ZINDELL, Renee M. , KHOR, Someina
IPC分类号： C07D207/16 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , A61K31/401 , A61K31/4015 , A61K31/402 , A61K31/4025
CPC分类号： C07D417/12 , C07D207/16 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04
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公开(公告)号：EP2074084B1
公开(公告)日：2013-08-28
申请号：EP07814833.5
申请日：2007-09-13
发明人： BERRY, Angela , CIRILLO, Pier Francesco , HICKEY, Eugene Richard , RIETHER, Doris , THOMSON, David , ZINDELL, Renee M. , ERMANN, Monika , JENKINS, James Edward , MUSHI, Innocent , TAYLOR, Malcolm , CHOWDHURY, Chandana , PALMER, Christopher Francis , BLUMIRE, Nigel
IPC分类号： C07C317/44 , A61K31/16 , A61P29/00 , A61P37/00 , C07D213/75 , C07D215/38 , C07D217/22 , C07D231/40 , C07D261/12 , C07D277/46 , C07D277/82 , C07D309/04 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/04 , C07D413/12 , C07D417/12
CPC分类号： C07C317/44 , C07D213/75 , C07D215/38 , C07D217/22 , C07D231/40 , C07D261/12 , C07D277/46 , C07D277/82 , C07D309/04 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/04 , C07D413/12 , C07D417/12
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公开(公告)号：EP3099674B1
公开(公告)日：2018-10-24
申请号：EP15704880.2
申请日：2015-01-23
发明人： BENTZIEN, Joerg , BERRY, Angela , BOSANAC, Todd , BURKE, Michael, J. , DISALVO, Darren , MAO, Can , MAO, Wang , SHEN, Yue
IPC分类号： C07D403/10 , C07D401/10 , A61K31/4155 , A61K31/454 , A61P19/02 , A61P29/00
CPC分类号： C07D403/04 , C07D401/04 , C07D401/10 , C07D403/10
摘要： The present invention encompasses compounds of the formula (I) wherein the groups R1, Cy, and Y are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.
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公开(公告)号：EP2766360A1
公开(公告)日：2014-08-20
申请号：EP12762428.6
申请日：2012-08-09
发明人： BERRY, Angela , BOSANAC, Todd , GINN, John David , HOPKINS, Tamara Denise , SCHLYER, Sabine , SOLEYMANZADEH, Fariba , WESTBROOK, John , YU, Maolin , ZHANG, Zhonghua
IPC分类号： C07D417/12 , C07D417/14 , A61K31/427 , A61P25/00
CPC分类号： C07D417/14 , C07D417/04 , C07D417/12
摘要： The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein R
1 - R
5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1 -R 5和n如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和用于这些方法的中间体。
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公开(公告)号：EP2384320A2
公开(公告)日：2011-11-09
申请号：EP09775474.1
申请日：2009-12-15
发明人： BERRY, Angela , BETAGERI, Rajashekhar , RIETHER, Doris , HICKEY, Eugene Richard , WU, Lifen , ZINDELL, Renee M. , KHOR, Someina
IPC分类号： C07D207/16 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , A61K31/401 , A61K31/4015 , A61K31/402 , A61K31/4025
CPC分类号： C07D417/12 , C07D207/16 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain. (I)
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公开(公告)号：EP2081905A2
公开(公告)日：2009-07-29
申请号：EP07813203.2
申请日：2007-07-23
发明人： BERRY, Angela , CIRILLO, Pier Francesco , HICKEY, Eugene Richard , RIETHER, Doris , THOMSON, David S. , ERMANN, Monika , JENKINS, James Edward , MUSHI, Innocent , TAYLOR, Malcolm , CHOWDHURY, Chandana , PALMER, Christopher Francis , BLUMIRE, Nigel
IPC分类号： C07D215/38 , C07D217/22 , C07D213/75 , C07D231/40 , C07D233/88 , C07D235/30 , C07D261/14 , C07D261/20 , C07D263/28 , C07D263/58 , C07D277/56 , C07D277/60 , C07D277/62 , C07D285/08
CPC分类号： C07D261/14 , C07C317/44 , C07D213/75 , C07D215/38 , C07D217/22 , C07D231/40 , C07D233/88 , C07D235/30 , C07D249/14 , C07D261/20 , C07D263/28 , C07D263/58 , C07D271/07 , C07D271/113 , C07D277/46 , C07D277/56 , C07D277/60 , C07D277/82 , C07D285/08 , C07D285/135 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
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