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1.发明公开IMIDAZOTHIADIAZOLE AND IMIDAZOPYRAZINE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION 审中-公开作为蛋白酶激活的受体4（PAR4）抑制剂治疗血小板聚集的咪唑并二氮杂和咪唑并吡嗪衍生物
公开(公告)号：EP3243826A1
公开(公告)日：2017-11-15
申请号：EP17172927.0
申请日：2013-04-24
发明人： BANVILLE, Jacques , RÉMILLARD, Roger , RUEDIGER, Edward H. , DEON, Daniel H. , GAGNON, Marc , DUBÉ, Laurence , GUY, Julia , PRIESTLEY, Eldon Scott , POSY, Shoshana L. , MAXWELL, Brad D. , WONG, Pancras C. , LAWRENCE, Michael R. , MILLER, Michael M.
IPC分类号： C07D519/00 , A61K31/433 , C07D513/04 , A61K31/5025 , C07D487/04 , A61K31/4355 , A61P7/02
摘要： The present invention provides thiazole compounds of Formula I
wherein W, Y, R 0 , R 2 , R 4 , R 5 , R 6 , R 7 , X 1 , X 2 , X 3 and X 4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.摘要翻译： 本发明提供了其中W，Y，R 0，R 2，R 4，R 5，R 6，R 7，X 1，X 2，X 3和X 4如本文所定义的式I的噻唑化合物或其立体异构体，互变异构体，药学上可接受的盐或溶剂合物形式 其中所有变量如本文所定义。 这些化合物是血小板聚集抑制剂，因此可以用作治疗或预防血栓栓塞病症的药物。
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2.发明授权IMIDAZOLYL BIPHENYL IMIDAZOLES AS HEPATITIS C VIRUS INHIBITORS 有权IMIDAZOLYLBIPHENYLIMIDAZOLE AS丙型肝炎病毒抑制剂
公开(公告)号：EP2242752B1
公开(公告)日：2012-08-08
申请号：EP08768910.5
申请日：2008-02-13
发明人： BACHAND, Carol , BELEMA, Makonen , DEON, Daniel H. , GOOD, Andrew C. , GOODRICH, Jason , JAMES, Clint A. , LAVOIE, Rico , LOPEZ, Omar D. , MARTEL, Alain , MEANWELL, Nicholas A. , NGUYEN, Van N. , ROMINE, Jeffrey Lee , RUEDIGER, Edward H. , SNYDER, Lawrence B. , ST. LAURENT, Denis R. , YANG, Fukang , LANGLEY, David R. , WANG, Gan , HAMANN, Lawrence G.
IPC分类号： C07D403/14 , C07D405/14 , C07D417/14 , A61P31/00 , A61K31/41
CPC分类号： C07D403/14 , C07D405/14 , C07D417/14
摘要： The present disclosure relates to compounds Formule (I), compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in. the treatment of HCV infection.
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公开(公告)号：EP2245027A1
公开(公告)日：2010-11-03
申请号：EP09709849.5
申请日：2009-02-06
发明人： BACHAND, Carol , BELEMA, Makonen , DEON, Daniel H. , GOOD, Andrew C. , GOODRICH, Jason , JAMES, Clint A. , LAVOIE, Rico , LOPEZ, Omar D. , MARTEL, Alain , MEANWELL, Nicholas A. , NGUYEN, Van N. , ROMINE, Jeffrey Lee , RUEDIGER, Edward H. , SNYDER, Lawrence B. , ST. LAURENT, Denis R. , YANG, Fukang , LANGLEY, David R. , WANG, Gan , HAMANN, Lawrence G.
IPC分类号： C07D403/14 , C07D405/14 , C07D487/04 , C07D491/044 , C07D491/052 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61P31/14
CPC分类号： C07D403/14 , C07D405/14 , C07D487/04 , C07D491/044 , C07D491/052
摘要： The present disclosure relates to compounds of structure (I), compositions and Methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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公开(公告)号：EP1943221A1
公开(公告)日：2008-07-16
申请号：EP06816178.5
申请日：2006-10-03
发明人： WANG, Tao , KADOW, John F. , MEANWELL, Nicholas A. , ZHANG, Zhongxing , YIN, Zhiwei , JAMES, Clint A. , RUEDIGER, Edward H. , PEARCE, Bradley C.
IPC分类号： C07D209/12 , C07D401/04 , C07D409/04 , C07D417/04 , C07D471/04 , C07F5/02 , A61K31/395 , A61P31/12 , A61P31/18
CPC分类号： C07D471/04 , C07D209/12 , C07D209/18 , C07D401/04 , C07D401/12 , C07D409/04 , C07D417/04 , C07F5/025
摘要： This disclosure provides compounds of Formula (I) as described herein having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with indole and azaindole piperazine diamide derivatives that possess unique antiviral activity. More particularly, the present disclosure relates to compounds useful for the treatment of HIV and AIDS. Formula (I) wherein: X is selected from the group consisting of formulae (II, III, IV and V); Y is formula (VI); Z is formula (VII).
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公开(公告)号：EP3632919A1
公开(公告)日：2020-04-08
申请号：EP19192142.8
申请日：2013-04-24
发明人： BANVILLE, Jacques , RÉMILLARD, Roger , RUEDIGER, Edward H. , DEON, Daniel H. , GAGNON, Marc , DUBÉ, Laurence , GUY, Julia , PRIESTLEY, Eldon Scott , POSY, Shoshana L. , MAXWELL, Brad D. , WONG, Pancras C. , LAWRENCE, Michael R. , MILLER, Michael M.
IPC分类号： C07D519/00 , A61K31/433 , C07D513/04 , A61K31/5025 , C07D487/04 , A61K31/4355 , A61P7/02
摘要： The present invention provides pharmaceutical compositions comprising an imidazothiadiazole or imidazopyridazine compound that is a PAR4 antagonist, a pharmaceutically acceptable carrier and another therapeutic agent.
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公开(公告)号：EP2013170B1
公开(公告)日：2012-06-27
申请号：EP07761192.9
申请日：2007-04-24
IPC分类号： C07D209/30 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04 , A61K31/437
CPC分类号： C07D209/14 , C07D209/16 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要： This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with 4-squarylpiperazine derivatives that possess unique antiviral activity. More particularly, the present disclosure relates to compounds useful for the treatment of HIV and AIDS.
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公开(公告)号：EP2049114A2
公开(公告)日：2009-04-22
申请号：EP07813926.8
申请日：2007-08-09
发明人： BACHAND, Carol , BELEMA, Makonen , DEON, Daniel H. , GOOD, Andrew C. , GOODRICH, Jason , JAMES, Clint A. , LAVOIE, Rico , LOPEZ, Omar D. , MARTEL, Alain , MEANWELL, Nicholas A. , NGUYEN, Van N. , ROMINE, Jeffrey Lee , RUEDIGER, Edward H. , SNYDER, Lawrence B. , ST. LAURENT, Denis R. , YANG, Fukang , LANGLEY, David R. , HAMANN, Lawrence G.
IPC分类号： A61K31/501 , A61K31/506 , A61K31/497 , A61P31/12
CPC分类号： C07D403/14 , A61K31/4178 , A61K31/4545 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D401/14 , C07F7/10
摘要： The present disclosure relates to compounds of formula (I), compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
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8.发明授权IMIDAZOTHIADIAZOLE AND IMIDAZOPYRAZINE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION 有权作为蛋白酶激活的受体4（PAR4）抑制剂治疗血小板聚集的咪唑并二氮杂和咪唑并吡嗪衍生物
公开(公告)号：EP2841437B1
公开(公告)日：2017-07-05
申请号：EP13721857.4
申请日：2013-04-24
发明人： BANVILLE, Jacques , RÉMILLARD, Roger , RUEDIGER, Edward H. , DEON, Daniel H. , GAGNON, Marc , DUBÉ, Laurence , GUY, Julia , PRIESTLEY, Eldon Scott , POSY, Shoshana L. , MAXWELL, Brad D. , WONG, Pancras C. , LAWRENCE, Michael, R. , MILLER, Michael, M.
IPC分类号： C07D519/00 , A61K31/433 , C07D513/04 , A61K31/5025 , C07D487/04 , A61K31/4355 , A61P7/02
CPC分类号： C07D513/04 , A61K31/433 , A61K31/435 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/5025 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/55 , A61K31/553 , A61K45/06 , A61K51/0453 , C07B59/002 , C07B2200/05 , C07D487/04 , C07D519/00
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公开(公告)号：EP2499132B1
公开(公告)日：2017-02-15
申请号：EP10779401.8
申请日：2010-11-10
发明人： LAVOIE, Rico , BENDER, John A. , ROMINE, Jeffrey Lee , RUEDIGER, Edward H. , BACHAND, Carol , LOPEZ, Omar D. , CHEN, Qi , BELEMA, Makonen , KADOW, John F. , HAMANN, Lawrence G.
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D403/14 , C07D409/14 , C07D417/14 , C07D493/08
CPC分类号： C07D417/14 , C07D401/14 , C07D403/06 , C07D403/10 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/10 , C07D419/10 , C07D493/08
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公开(公告)号：EP2242751B1
公开(公告)日：2015-07-15
申请号：EP09711416.9
申请日：2009-02-10
发明人： BACHAND, Carol , MAKONEN, Belema , DEON, Daniel H. , GOOD, Andrew C. , GOODRICH, Jason , JAMES, Clint A. , LAVOIE, Rico , LOPEZ, Omar D. , MARTEL, Alain , MEANWELL, Nicholas A. , NGUYEN, Van N. , ROMINE, Jeffrey Lee , RUEDIGER, Edward H. , SNYDER, Lawrence B. , ST. LAURENT, Denis R. , YANG, Fukang , LANGLEY, David R. , WANG, Gan , HAMANN, Lawrence G.
IPC分类号： C07D403/14 , A61K31/517 , A61P31/00
CPC分类号： C07D403/14
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