公开(公告)号：EP1817322A2

公开(公告)日：2007-08-15

申请号：EP05817494.7

申请日：2005-11-15

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE

发明人： ROBERT, Véronique ,  VINET, Françoise

IPC分类号： C07H15/04 ,  G01N33/548 ,  G01N33/543 ,  G01N33/66

CPC分类号： G01N33/66 ,  C07H15/04 ,  G01N33/54353 ,  G01N2400/00

摘要： The invention relates to silanizing agents comprising a saccharide end group and to the use thereof for the functionalization of solid supports. The invention also relates to solid supports that have been functionalized by said silanizing agents (glycochips) and to the use of same, such for biological analysis and, in particular, for screening saccharide molecules or proteinaceous ligands of interest.

公开(公告)号：EP1346203A1

公开(公告)日：2003-09-24

申请号：EP01270761.8

申请日：2001-12-12

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE

发明人： CHATON, Patrick ,  VINET, Françoise ,  BARRITAULT, Pierre ,  GETIN, Stéphane

IPC分类号： G01N21/64

CPC分类号： G01N21/6428 ,  G01N21/6458 ,  Y10S435/808

摘要： The invention concerns a device for enhancing fluorescence comprising a support (10) supporting fluorescence enhancing means (11), the fluorescence enhancing means providing a surface for receiving chemical or biological elements to be read by detection of a fluorescence signal emitted by a fluorophore, associated with the chemical or biological elements, under the effect of an excitation light beam. The fluorescence enhancing means (11) consist of a thin transparent dielectric layer or a stack of thin transparent dielectric layers (12 to 16) ensuring a mirror function for the fluorescence signals and for the excitation light beam, the material of the thin layer or of each thin layer of the stack being selected among the following materials: TiO2, Ta2O5, HfO2, ZrO2, MgO, SiO2, Si3N4, MgF2, YF3. The invention is applicable to a biological or chemical optical sensor.

公开(公告)号：EP1216410B1

公开(公告)日：2009-12-30

申请号：EP00966233.9

申请日：2000-09-29

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE

发明人： VINET, Françoise ,  CHATON, Patrick

IPC分类号： G01N21/17 ,  C12Q1/68

CPC分类号： G01N21/171

公开(公告)号：EP1771244A1

公开(公告)日：2007-04-11

申请号：EP05790710.7

申请日：2005-07-05

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ,  Centre National de la Recherche Scientifique

发明人： MARCHAND, Gilles ,  VINET, Françoise ,  DELAPIERRE, Guillaume ,  HASSINE, Fatima ,  GMOUH, Saïd ,  VAULTIER, Michel

IPC分类号： B01J19/00 ,  B01L3/00 ,  G01N27/447

CPC分类号： C07D221/18 ,  B01F13/0071 ,  B01F13/0076 ,  B01J14/00 ,  B01J19/0093 ,  B01L3/502792 ,  B01L2300/0816 ,  B01L2300/089 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0427 ,  B01L2400/0433 ,  B01L2400/0442 ,  B01L2400/0487 ,  C07C41/14 ,  C07C227/16 ,  C12P17/12 ,  G01N2035/1046

摘要： The invention relates to a drop microreactor, i.e. a microreactor comprised of a drop of a particular liquid, whereby this microreactor does not walls, and the interface of the particular liquid with the ambient medium and with the support onto which the drop is deposited define the boundaries of the microreactor. The microreactor is characterized in that it is comprised of a drop containing at least one ionic liquid. The invention also relates to methods for carrying out chemical or biochemical reactions and/or a mixture of the two while using said microreactor as well as to a lab-on-chip comprising a microreactor of the aforementioned type.

公开(公告)号：EP1570101A2

公开(公告)日：2005-09-07

申请号：EP03799710.3

申请日：2003-12-04

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE

发明人： DELAUNAY, Marc ,  VINET, Françoise

IPC分类号： C23C14/00 ,  C23C16/26 ,  C01B31/02 ,  C23C14/58 ,  C23C16/02 ,  B82B3/00

CPC分类号： C23C14/5846 ,  B82Y30/00 ,  C01B32/914 ,  C01P2004/13 ,  C01P2004/64 ,  C01P2004/82 ,  C23C14/0036 ,  C23C14/08 ,  C23C14/58

摘要： The invention relates to a method of synthesising nanorods from a carbide of a metal M1 on a substrate. The inventive method consists in: (a) depositing, on the substrate, a layer of oxide nanocrystals of metal M1 and oxide nanocrystals of at least one other metal M2 which is different from metal M1, the oxide nanocrystals of metal M1 being dispersed in said layer; (b) reducing the oxide nanocrystals of metals M1 and M2 into the corresponding metals; and (c) selectively growing nanocrystals of metal M1. The invention also relates to a method of growing nanorods of a carbide of metal M1 on a substrate from nanocrystals of said material, to the substrates thus obtained and to the applications thereof, such as in the production of: microsystems comprising chemical or biological functions and, in particular, biosensors; electron-emitting sources, e.g. for flat television or computer screens, etc.

公开(公告)号：EP1163049B1

公开(公告)日：2005-05-25

申请号：EP00909431.9

申请日：2000-03-06

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE

发明人： ROSILIO, Charles ,  VINET, Françoise ,  VAUCHIER, Claude ,  CLERC, Jean-Frédéric

IPC分类号： B01J19/00 ,  C07H21/00

CPC分类号： B01L3/5085 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00351 ,  B01J2219/00364 ,  B01J2219/00382 ,  B01J2219/00511 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01L3/5088 ,  C40B40/06 ,  C40B60/14 ,  G01N33/54353 ,  G01N33/6818

摘要： The invention concerns the production of a matrix of sequences of chemical or biological molecules, and more particularly of oligonucleotides by in situ synthesis on a substrate comprising microwells. Said substrate comprises microwells (3) which can, for example, be functionalised by reactive groups (5) protected by protector groups (7). In order to couple the first molecule of the desired sequences on the selected microwells, the method consists in: covering the other microwells with a protective polymer (9), then in performing a chemical reaction on the unprotected microwells, for example by eliminating the protector groups (7) and by coupling the reactive groups (5) with the first molecule of the sequence, then in repeating said operations with other molecules on other microwells, after removing the protective polymer and resetting the protective polymer on the microwells which should not contain the next molecule.

公开(公告)号：EP1344062A1

公开(公告)日：2003-09-17

申请号：EP01994906.4

申请日：2001-12-19

申请人： Commissariat A L'Energie Atomique

发明人： CHATON, Patrick ,  VINET, Françoise

IPC分类号： G01N33/543 ,  C12Q1/68 ,  G01N21/64

CPC分类号： G01N33/54393

摘要： The invention concerns an analysis support for determining an analyte such as a target DNA or RNA, by using a specific binding reaction (hybridization) of said analyte with a ligand specific of said analyte, and determining the binding reaction using at least two fluorescent markers present on the analyte. Said determination is carried out by applying an excitation field and by detecting the fluorescent emission of the different fluorescent markers. The invention is characterised in that the support comprises a substrate coated with one or several material layers forming an assembly capable of attenuating or increasing the excitation field for at least one of the fluorescent markers relative to the others. The ligands are fixed on the last layer of the assembly. A SiO2 layer on a silicon substrate can be used with the Cy3 and Cy5 fluorescent markers.

公开(公告)号：EP1744828A1

公开(公告)日：2007-01-24

申请号：EP05762681.4

申请日：2005-05-12

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ,  THALES ANGENIEUX S.A.

发明人： DELAPIERRE, Guillaume ,  VINET, Françoise ,  PEGON, Philippe

IPC分类号： B01J19/00

CPC分类号： B82Y30/00 ,  B01J19/0046 ,  B01J2219/00378 ,  B01J2219/00387 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00596 ,  B01J2219/00641 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00691 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  B05D1/185 ,  B82Y40/00 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B60/14 ,  G01N33/54353

摘要： The invention relates to a sol-gel process for the functionalisation of a surface of a solid substrate in order to provide said surface with chemical functions that can react with chemical or biological molecules, i.e. chemical functions that can immobilise, attach, graft biological or chemical molecules. The invention can be used, for example, in the preparation of chemical and biological sensors, such as for the production of chips comprising DNA, oligonucleotides, sugars, peptides and small organic molecules.

公开(公告)号：EP1718657A1

公开(公告)日：2006-11-08

申请号：EP05728104.0

申请日：2005-02-22

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE

发明人： PERETTI, Véronique ,  VINET, Françoise ,  BONNAFFE, David

IPC分类号： C07H3/02 ,  G01N33/543

CPC分类号： C07H3/02 ,  G01N33/54353 ,  Y02P20/55

摘要： The invention relates to a molecular spacer, to a method of fixing a molecular unit to a solid support and to the use of said spacer on analysis chips with molecules or biomolecules. According to the invention, the spacer has formula (I) wherein: X0, X4 = C, O, S, Se, N, P, As; X1-3 = C, O, N, S, Se, P, As, or aryl, heteroaryl at C1-6; Z1-2 = C-R, Si-R, N, P and As, where R = alkyl at C1-6; R1-3 = H, or alkyl, aryl, heteroaryl at C1-6; [Gp] = protective group of >N; n, m and n = integers = 1; [Sup] = H or a silanised solid support; and [mo] = H or a molecular unit which is intended to be fixed covalently by means of the spacer to the silanised solid support.

公开(公告)号：EP1626977A2

公开(公告)日：2006-02-22

申请号：EP04742596.2

申请日：2004-04-28

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  Université de Montpellier II

发明人： VINET, Françoise ,  LANNEAU, Gérard ,  GRANIER, Michel ,  MARTIN, Franck

IPC分类号： C07F7/08

CPC分类号： B82Y30/00 ,  B82Y40/00 ,  C07F7/0896 ,  G01N33/54353 ,  G01N33/54393

摘要： The invention relates to ω-silanyl n-alkanal compounds, method for production and use thereof in the functionalisation of solid supports, solid supports functionalised by means of said compounds and the use of solid supports thus functionalised for the immobilisation and/or synthesis of biological molecules of interest.