公开(公告)号：EP2129395A2

公开(公告)日：2009-12-09

申请号：EP08799657.5

申请日：2008-03-27

申请人： The Regents of the University of California ,  Duke University ,  THE UNIVERSITY OF ALABAMA AT BIRMINGHAM ,  UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

发明人： HAYNES, Barton, F. ,  KORBER, Bette, T. ,  HAHN, Beatrice, H. ,  BHATTACHARYA, Tanmoy ,  GNANAKARAN, Gnana, S. ,  GAO, Feng ,  SWANSTROM, Ron ,  SHAW, George

IPC分类号： A61K39/21

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  C12N2740/16122 ,  C12N2740/16134

摘要： The present invention relates, in general, to human immunodeficiency virus (HIV) and, in particular, to a method of inducing an immune response to HIV in a patient and to immunogens suitable for use in such a method. The invention also relates to diagnostic test kits and methods of using same.

公开(公告)号：EP1667714B1

公开(公告)日：2018-01-03

申请号：EP04784298.4

申请日：2004-09-17

申请人： Duke University ,  The University of Alabama at Birmingham Research Foundation ,  The Regents of the University of California

发明人： HAYNES, Barton, F. ,  GAO, Feng ,  KORBER, Bette, T. ,  HAHN, Beatrice, H. ,  SHAW, George, M. ,  KOTHE, Denise ,  LI, Ying Ying ,  DECKER, Julie ,  LIAO, Hua-Xin

IPC分类号： A61K39/21 ,  C07H21/04 ,  C12N5/02 ,  C12N15/74

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/005 ,  C07K16/4225 ,  C12N2740/15022 ,  C12N2740/15034 ,  C12N2740/16034 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  C12N2740/16322

摘要： The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.

公开(公告)号：EP3119890A1

公开(公告)日：2017-01-25

申请号：EP15764507.8

申请日：2015-03-19

申请人： Duke University ,  Los Alamos National Security, LLC

发明人： HAYNES, Barton, F. ,  GAO, Feng ,  KORBER, Bette, T. ,  HRABER, Peter, T.

IPC分类号： C12N15/46 ,  C07K14/155 ,  C12N15/85 ,  A61K39/21

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/55555 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/24143 ,  C12N2740/16134

摘要： In certain aspects the invention provides HIV-1 immunogens, including envelopes (CH505) and selections therefrom, and methods for swarm immunizations using combinations of HIV-1 envelopes.

摘要翻译： 在某些方面，本发明提供HIV-1免疫原，包括信封（CH505）及其选择，以及使用HIV-1包膜组合的群体免疫的方法。

公开(公告)号：EP3049524A1

公开(公告)日：2016-08-03

申请号：EP14849379.4

申请日：2014-09-26

申请人： Duke University

发明人： HAYNES, Barton, F. ,  PERMAR, Sallie ,  MOODY, M., Anthony ,  GAO, Feng ,  LIAO, Hua-Xin ,  TOMARAS, Georgia ,  MONTEFIORI, David, C.

IPC分类号： C12N15/49 ,  C07K14/16 ,  A61K31/7088 ,  A61P31/18 ,  G01N33/50

CPC分类号： A61K31/7088 ,  A61K2039/505 ,  C07K14/005 ,  C07K16/1063 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/76 ,  C12N2770/00041 ,  G01N33/56988 ,  G01N2800/50

摘要： The invention provides compositions and methods to induce and boost antibody response, including but not limited to IgG responses binding to HIV-1 in a subject in need thereof, wherein the induced/boosted plasma level of the antibody responses, for example V3 and/or CD4 binding site antibody responses, is over a threshold level and is associated with reduced risk of maternal-to-child-transmission (MTCT) of HIV-1.

摘要翻译： 本发明提供诱导和增强抗体应答的组合物和方法，包括但不限于在有需要的受试者中结合HIV-1的IgG应答，其中所述抗体应答的诱导/升高的血浆水平，例如V3和/或 CD4结合位点抗体应答超过阈值水平，与HIV-1的母婴传播风险（MTCT）相关。

公开(公告)号：EP2094296A2

公开(公告)日：2009-09-02

申请号：EP07867507.1

申请日：2007-11-19

申请人： Duke University

发明人： HAYNES, Barton F. ,  SMITH, Nancy G. ,  ALAM, S., Munir ,  GAO, Feng ,  LIAO, Hua-Xin

IPC分类号： A61K39/00

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  A61K39/385 ,  A61K39/39 ,  A61K39/39533 ,  A61K39/3955 ,  A61K39/42 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/6018 ,  C07K2319/04 ,  C12N15/86 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2760/20243

摘要： The present invention relates, in general, to human immunodeficiency virus (HIV) and, in particular, to a multicomponent vaccine and method of using same to protect against HTV-I infection.

公开(公告)号：EP2566884A2

公开(公告)日：2013-03-13

申请号：EP11777718.5

申请日：2011-05-09

申请人： Duke University ,  Los Alamos National Security, LLC ,  Musonda, Rosemary

发明人： MUSONDA, Rosemary ,  HAYNES, Barton, F. ,  GAO, Feng ,  KORBER, Bette, T. ,  MONTEFIORI, David

IPC分类号： C07K14/155 ,  C12N15/49 ,  A61K39/21 ,  A61K39/42 ,  A61P29/00 ,  A61P31/18

CPC分类号： A61K39/42 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/53 ,  C07K14/005 ,  C12N2740/16122 ,  C12N2740/16134

摘要： The present invention relates, in general, to HIV-1 and, in particular, to immunogens that elicit broadly neutralizing antibodies against HIV-1 subtype C envelope glycoproteins, and compositions comprising same. The invention further relates to methods of inducing the production of such antibodies in a subject.

公开(公告)号：EP2895500A1

公开(公告)日：2015-07-22

申请号：EP13837551.4

申请日：2013-09-12

申请人： Duke University ,  Los Alamos National Security LLC ,  The Trustees Of The University Of Pennsylvania ,  Trustees of Boston University ,  The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services ,  The Board of Trustees of the Leland Stanford Junior University

发明人： HAYNES, Barton, F. ,  LIAO, Hua-Xin ,  LYNCH, Rebecca, M. ,  ZHOU, Tongqing ,  GAO, Feng ,  BOYD, Scott ,  SHAW, George, M. ,  HAHN, Beatrice, H. ,  KEPLER, Thomas, B. ,  KORBER, Bette, T. ,  KWONG, Peter ,  MASCOLA, John

IPC分类号： C07K14/155 ,  A61K39/12 ,  A61P31/18

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/57 ,  C07K14/005 ,  C12N7/00 ,  C12N2740/15022 ,  C12N2740/16022 ,  C12N2740/16122 ,  C12N2740/16134

摘要： The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).

摘要翻译： 本发明一般涉及HIV-1，特别涉及广泛中和HIV-1抗体和HIV-1免疫原，以及涉及使用此类免疫原以诱导产生广泛中和HIV-1抗体的方法 主题（例如，人）。

公开(公告)号：EP1667714A2

公开(公告)日：2006-06-14

申请号：EP04784298.4

申请日：2004-09-17

申请人： Duke University ,  The University of Alabama at Birmingham Research Foundation ,  The Regents of the University of California

发明人： HAYNES, Barton, F. ,  GAO, Feng ,  KORBER, Bette, T. ,  HAHN, Beatrice, H. ,  SHAW, George, M. ,  KOTHE, Denise ,  LI, Ying Ying ,  DECKER, Julie ,  LIAO, Hua-Xin

IPC分类号： A61K39/21 ,  C07H21/04 ,  C12N5/02 ,  C12N15/74

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/005 ,  C07K16/4225 ,  C12N2740/15022 ,  C12N2740/15034 ,  C12N2740/16034 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  C12N2740/16322

摘要： The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.

摘要翻译： 本发明一般涉及免疫原，特别涉及用于诱导中和广谱HIV原发分离株和/或诱导T细胞免疫应答的免疫原的抗体的免疫原。 本发明还涉及使用这种免疫原诱导抗HIV抗体的方法，和/或诱导T细胞免疫应答的方法。 本发明还涉及编码本发明免疫原的核酸序列。