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1.发明公开
公开(公告)号：EP2431054A2
公开(公告)日：2012-03-21
申请号：EP10011219.2
申请日：2001-06-14
发明人： Yu, Guo-Liang , Ni, Jian , Gentz, Reiner L. , Dillon, Patrick J.
IPC分类号： A61K47/00 , A61K47/48 , A61K49/00 , C07K14/52 , C07K14/705 , C07K16/28 , G01N33/564
CPC分类号： A61K49/0004 , A61K47/6849 , A61K2039/505 , C07K14/52 , C07K14/70575 , C07K16/2875 , C07K2317/21 , C07K2317/622 , G01N33/564
摘要： The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译： 本发明涉及人TNFδ和TNFε多肽，编码多肽的多核苷酸，用于产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。
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公开(公告)号：EP1491550A1
公开(公告)日：2004-12-29
申请号：EP04008021.0
申请日：1999-11-09
发明人： Ruben, Steven M. , Birse, Charles E. , Ni, Jian , Rosen, Graig A. , Carter, Kenneth C. , Komatsoulis, George A. , Ebner, Reinhard , Young, Paul , Florence, Kiemberly A.
IPC分类号： C07H21/02 , C07H19/00 , C07H21/04 , C07H21/00 , C12Q1/68 , G01N33/53 , C12P21/06 , C12P21/08 , C12N15/00 , C12N15/09
CPC分类号： C07K14/47 , A01K2217/075 , A61K38/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 人类分泌的多核苷酸及其编码的蛋白质是新的。 独立权利要求包括以下内容：（1）分离的核酸分子（I），其包含具有与以下序列之一至少95％相同的核苷酸序列的多核苷酸：（a）31个定义的基因之一的多核苷酸片段 说明书中给出的序列（A）或包含在与（A）可杂交的31个ATCC沉积物（C）之一中的cDNA序列的多核苷酸片段; （b）编码本说明书中给出的31个定义序列（B）之一的多肽片段或（C）的多核苷酸片段的多核苷酸; （c）编码（B）的多肽结构域或由（C）编码的多肽结构域的多核苷酸; （d）编码（B）的多肽表位或由（C）编码的多肽表位的多核苷酸; （e）编码具有生物活性的（B）的多肽或（C）所包含的cDNA序列的多核苷酸的多核苷酸; （f）作为（A）的变体的多核苷酸; （g）作为（A）的等位变体的多核苷酸; （h）编码（B）的物种同系物的多核苷酸; 或（i）能够在严格条件下与（a） - （h）的多核苷酸中的任一种杂交但不与仅具有A或T残基的核苷酸序列的核酸分子杂交的多核苷酸; （2）包含（I）的重组载体; （3）制备包含（I）的重组宿主细胞的方法; （4）通过（3）的方法制备的重组宿主细胞; （5）分离的多肽（II），其包含与以下序列之一至少95％相同的氨基酸序列：（a）（B）的多肽片段或（C）中包含的编码序列; （b）（B）的多肽片段或（C）中包含的具有生物活性的编码序列; （c）（B）的多肽表位或（C）中包含的编码序列; （d）（B）的分泌形式或（C）中包含的编码序列; （e）（B）的全长蛋白质或（C）中包含的编码序列; （f）（B）的变体; （g）（B）的等位基因变体; 或（h）（B）的物种同源物; （6）特异性结合（II）的分离抗体; （7）表达（II）的重组宿主细胞; （8）制备（II）的方法，包括在使多肽表达并回收多肽的条件下培养（7）的重组宿主细胞; （9）用于诊断受试者的病理状况或病理状态敏感性的方法，包括：（I）中确定是否存在突变并基于突变的存在或不存在进行诊断; （10）用于诊断受试者的病理状况或病理状态敏感性的方法，包括测定生物样品中（II）的表达的存在或数量，并基于蛋白质的表达的存在或数量进行诊断 ; （11）鉴定与（II）的结合伴侣的方法，包括使（II）与结合配偶体接触并确定对（II）的活性的任何影响; （12）对应于（C）的cDNA序列的基因; （13）鉴定生物测定中的活性的方法，包括在宿主细胞中表达（A），分离上清液，检测生物测定中的活性并用活性鉴定上清液中的蛋白质; 和（14）通过（13）的方法鉴定的产物。 活动：细胞抑制 增殖; 抗过敏; 皮肤; 免疫抑制; 抗心律不整; Cardiant; 伤药; 抗菌; 杀病毒。 在含有4％胎牛血清（FBS），16单位/ ml肝素和50单位/ ml内皮细胞生长的M199培养基中，将人脐静脉内皮细胞（HUVEC）以2-5×10 4个细胞/ 35mm培养皿密度接种 补充剂。 第二天，用含有10％FBS和8单位/ ml肝素的M199代替培养基。 具有氨基酸序列（B）和阳性对照例如 以各种浓度加入碱性成纤维细胞生长因子（bFGF）。 培养基在第4天和第6天更换，第8天用Coulter计数器测定细胞数。 HUVEC细胞数量的增加将表明本发明的多肽增殖血管内皮细胞。 没有结果。 作用机制：基因治疗。
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公开(公告)号：EP1352962A1
公开(公告)日：2003-10-15
申请号：EP03006291.3
申请日：1998-03-06
发明人： Olsen, Henrik S. , Yu, Guo-Liang , Endress, Gregory A. , Bednarik, Daniel P. , Carter, Kenneth C. , Feng, Ping , Soppet, Daniel R. , Young, Paul E. , Duan, D. Roxanne , Florence, Kimberly A. , Greene, John M. , Fischer, Carrie L. , Hu, Jing-Shan , Ruben, Steven M. , Ebner, Reinhard , Brewer, Laurie A. , Ferrie, Ann M. , Moore, Paul A. , Ni, Jian , Shi, Yanggu , Lafleur, David W. , Li, Yi , Zeng, Zhizhen , Kyaw, Hla , Rosen, Craig A.
IPC分类号： C12N15/12 , C12N5/10 , C12N1/21 , C07K14/47 , C07K16/18 , C12Q1/68 , G01N33/50 , G01N33/53 , G01N33/68 , A61K38/17
摘要： The present invention relates to 186 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及186种新型人分泌蛋白和含有编码这种蛋白质的基因的编码区的分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病的诊断和治疗方法。
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公开(公告)号：EP0972030A2
公开(公告)日：2000-01-19
申请号：EP98905127.1
申请日：1998-03-06
发明人： Ruben, Steven M. , Rosen, Craig A. , Fischer, Carrie L. , Soppet, Daniel R. , Carter, Kenneth C. , Bednarik, Daniel P. , Endress, Gregory A. , Yu, Guo-Liang , Ni, Jian , Feng, Ping , Young, Paul E. , Greene, John M. , Ferrie, Ann M. , Duan, Roxanne , Hu, Jing-Shan , Florence, Kimberley A. , Olsen, Henrik S. , Ebner, Reinhard , Brewer, Laurie A. , Shi, Yanggu , Lafleur, David W. , Li, Yi , Zeng, Zhizhen , Kyaw, Hla
IPC分类号： C12N15/12 , C12N5/10 , C12N1/21 , C07K14/47 , C07K16/18 , C12Q1/68 , G01N33/50 , G01N33/53 , G01N33/68 , A61K38/17
摘要： The present invention relates to 186 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及186种新的人分泌蛋白和含有编码这些蛋白的基因的编码区的分离的核酸。 还提供了用于产生人分泌蛋白的载体，宿主细胞，抗体和重组方法。 本发明进一步涉及诊断和治疗方法，用于诊断和治疗与这些新型人分泌蛋白相关的病症。
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公开(公告)号：EP1712631A3
公开(公告)日：2009-01-21
申请号：EP06010773.7
申请日：1998-01-20
发明人： Olsen, Henrik , Ni, Jian , Murphy, Marianne , Ruben, Steven , Gentz, Reiner
CPC分类号： C07K14/70535
摘要： The present invention relates to five novel Fc receptor-like proteins which are members of the Fc Receptor family. In particular, isolated nucleic acid molecules are provided encoding the human FcR-I, FcR-II, FcR-III, FcR-IV and FcR-V proteins. FcR-I, FcR-II, FcR-III, FcR-IV and FcR-V polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of FcR-I, FcR-II, FcR-III, FcR-IV and FcR-V activities. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
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6.发明公开VEGI, an inhibitor of angiogenesis and tumor growth 审中-公开VEGI，ein Hemmstoff der Angiogenese und Tumorwachstum
公开(公告)号：EP1992633A1
公开(公告)日：2008-11-19
申请号：EP08001068.9
申请日：1998-11-02
发明人： Li, Lu-Yuan , Zhai, Yifan , Yu, Guo-Liang , Ni, Jian , Lippman, Marc, E. , Rosen, Craig, A.
CPC分类号： C07K14/70575 , A61K38/00 , C12N2799/026 , Y02A50/406
摘要： The present invention relates to a vascular endothelial cell inhibitor, VEGI, capable of inhibiting angiogenesis in cellular models and tumourigenesis in animal models, and methods of use.
摘要翻译： 本发明涉及能够抑制动物模型中细胞模型中的血管生成和肿瘤发生的血管内皮细胞抑制剂VEGI及其使用方法。
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公开(公告)号：EP1577391A1
公开(公告)日：2005-09-21
申请号：EP05012261.3
申请日：1996-10-25
发明人： Yu, Guo-Liang , Ebner, Reinhard , Ni, Jian
CPC分类号： C07K14/52 , A61K38/00 , A61K2039/505 , Y02A50/412
摘要： The present invention relates to a novel Neutrokine alpha protein which is a member of the TNF protein family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine alpha protein including soluble forms of the extracellular domain. Neutrokine alpha polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine alpha activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
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公开(公告)号：EP1439189A2
公开(公告)日：2004-07-21
申请号：EP04008119.2
申请日：1998-06-11
发明人： Ruben, Steven M. , Ni, Jian , Rosen, Craig A: , Ebner, Reinhard , Young, Paul , Moore, Paul A , Feng, Ping , LaFleur, David W. , Olsen, Henrik S. , Yanggu, Shi , Brewer, Laurie A. , Greene, John M. , Ferrie, Ann M. , Yu, Guo-Liang
CPC分类号： C07K14/47 , G01N2500/00
摘要： The present invention relates to 86 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及以SEQ ID 26和126为特征的人分泌蛋白质，并且在子宫内膜肿瘤中表达。 还提供了用于产生蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与该蛋白质相关的病症的诊断和治疗方法。
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公开(公告)号：EP1428833A2
公开(公告)日：2004-06-16
申请号：EP04001119.9
申请日：1998-06-04
发明人： Young, Paul , Greene, John M. , Ferrie, Ann M. , Ruben, Steven M. , Rosen, Craig A. , Hu, Jing-Shan , Olsen, Henrik S. , Ebner, Reinhard , Brewer, Laurie A. , More, Paul A. , Shi, Yanggu , Florence, Charles , Florence, Kimberly , LaFleur, David W. , Ni, Jian , Fan, Ping , Wei, Ying-Fei , Fischer, Carrie L. , Soppet, Daniel R. , Li, Yi , Zeng, Zhizhen , Kyaw, Hla , Yu, Guo-Liang , Feng, Ping , Dillon, Patrick J. , Endress, Gregory A. , Carter, Kenneth C.
IPC分类号： C07K14/435 , C12N1/20 , C12N15/00 , C12N15/09 , C12N15/63 , G01N33/53 , A61K38/17 , A61K39/395 , A61K48/00
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regionsof the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：EP1394252A3
公开(公告)日：2004-03-10
申请号：EP03009752.1
申请日：1998-03-06
发明人： Olsen, Henrik S. , Yu, Guo-Liang , Endress, Gregory A. , Bednarik, Daniel P. , Carter, Kenneth C. , Feng, Ping , Soppet, Daniel R. , Young, Paul E. , Duan, D. Roxanne , Florence, Kimberly A. , Greene, John M. , Fischer, Carrie L. , Hu, Jing-Shan , Ruben, Steven M. , Ebner, Reinhard , Brewer, Laurie A. , Ferrie, Ann M. , Moore, Paul A. , Ni, Jian , Shi, Yanggu , Lafleur, David W. , Li, Yi , Zeng, Zhizhen , Kyaw, Hla , Rosen, Craig A.
IPC分类号： C12N15/12 , C12N5/10 , C12N1/21 , C07K14/47 , C07K16/18 , C12Q1/68 , G01N33/50 , G01N33/53 , G01N33/68 , A61K38/17
CPC分类号： C07K14/47
摘要： The present invention relates to 70 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
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