公开(公告)号：EP1228082A1

公开(公告)日：2002-08-07

申请号：EP00947553.4

申请日：2000-07-20

申请人： Human Genome Sciences, Inc.

发明人： ROSEN, Craig, A. ,  RUBEN, Steven, M. ,  EBNER, Reinhard ,  DUAN, Roxanne, D. ,  NI, Jian ,  SOPPET, Daniel, R. ,  MOORE, Paul, A. ,  SHI, Yang-gu ,  LAFLEUR, David, W. ,  OLSEN, Henrik, S. ,  BIRSE, Charles, E. ,  KOMATSOULIS, Georges, A.

IPC分类号： C07H21/04 ,  C07K5/04 ,  C07K16/00 ,  G01N33/53

CPC分类号： C07H21/04 ,  C07K14/47 ,  C07K16/18 ,  C07K2317/622 ,  C07K2319/30

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

公开(公告)号：EP1119369A1

公开(公告)日：2001-08-01

申请号：EP99942058.1

申请日：1999-08-10

申请人： HUMAN GENOME SCIENCES, INC.

发明人： HU, Jing-Shan ,  OLSEN, Henrik, S. ,  ROSEN, Craig, A.

IPC分类号： A61K38/18 ,  A61K48/00 ,  C07K14/475 ,  C07K16/22 ,  C12N1/21 ,  C12N15/16 ,  C12N15/63 ,  G01N33/53

CPC分类号： C07K14/515 ,  A61K38/00 ,  A61K48/00

摘要： The present invention relates to a human protein called Vascular Endothelial Growth Factor 3, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for production. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this human protein.

公开(公告)号：EP0902791A1

公开(公告)日：1999-03-24

申请号：EP96910816.0

申请日：1996-04-10

申请人： HUMAN GENOME SCIENCES, INC.

发明人： OLSEN, Henrik, S. ,  RUBEN, Steven, M.

IPC分类号： C12N15 ,  A61K31 ,  A61K38 ,  A61K39 ,  A61K45 ,  A61K48 ,  A61P43 ,  C07K14 ,  C07K16 ,  C12N1 ,  C12N5 ,  C12P21 ,  C12Q1 ,  G01N33

CPC分类号： C07K14/485 ,  A61K38/00 ,  A61K48/00 ,  C12Q1/6883 ,  C12Q2600/156

摘要： The present invention discloses an extracellular/epidermal growth factor polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include induction of cell growth and differentiation, stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders, treating Marfan syndrome and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia and diabetes. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.

公开(公告)号：EP1317472A1

公开(公告)日：2003-06-11

申请号：EP01984565.0

申请日：2001-01-17

申请人： Human Genome Sciences, Inc.

发明人： ROSEN, Craig, A. ,  KOMATSOULIS, George, A. ,  BAKER, Kevin, P. ,  BIRSE, Charles, E. ,  SOPPET, Daniel, R. ,  OLSEN, Henrik, S. ,  MOORE, Paul, A. ,  WEI, Ping ,  EBNER, Reinhard ,  DUAN, Roxanne, D. ,  SHI, Yanggu ,  CHOI, Gil, H. ,  FISCELLA, Michele ,  NI, Jian

IPC分类号： C07H21/04 ,  C07H21/02 ,  C07H5/00 ,  C07K14/00 ,  C12Q1/68 ,  C12N1/21 ,  C12N15/63 ,  C12N15/85 ,  C12N15/86

CPC分类号： C07K14/70571 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4713

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

公开(公告)号：EP1311669A1

公开(公告)日：2003-05-21

申请号：EP01984537.9

申请日：2001-01-17

申请人： Human Genome Sciences, Inc.

发明人： ROSEN, Craig, A. ,  KOMATSOULIS, George, A. ,  BAKER, Kevin, P. ,  BIRSE, Charles, E. ,  SOPPET, Daniel, R. ,  OLSEN, Henrik, S. ,  MOORE, Paul, A. ,  WEI, Ping ,  EBNER, Reinhard ,  DUAN, D., Roxanne ,  SHI, Yanggu ,  CHOI, Gil, H. ,  FISCELLA, Michele ,  NI, Jian

IPC分类号： C12N15/00

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K48/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

公开(公告)号：EP1254242A1

公开(公告)日：2002-11-06

申请号：EP01910339.9

申请日：2001-01-17

申请人： HUMAN GENOME SCIENCES, INC.

发明人： ROSEN, Craig, A. ,  KOMATSOULIS, George, A. ,  BAKER, Kevin, P. ,  BIRSE, Charles, E. ,  SOPPET, Daniel, R. ,  OLSEN, Henrik, S. ,  MOORE, Paul, A. ,  WEI, Ping ,  EBNER, Reinhard ,  DUAN, D., Roxanne ,  SHI, Yanggu ,  CHOI, Gil, H. ,  FISCELLA, Michele ,  NI, Jian ,  RUBEN, Steven, M. ,  BARASH, Steven, C.

IPC分类号： C12N15/60 ,  C12N9/88 ,  A61K31/00

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K16/18 ,  C07K2319/30 ,  C12N9/6424 ,  C12N2799/026 ,  C12Q1/6883 ,  G01N2500/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

公开(公告)号：EP1218408A1

公开(公告)日：2002-07-03

申请号：EP00965302.3

申请日：2000-09-22

申请人： Human Genome Sciences, Inc.

发明人： NI, Jian ,  BAKER, Kevin, P. ,  BIRSE, Charles, E. ,  EBNER, Reinhard ,  FISCELLA, Michele ,  KOMATSOULIS, George, A. ,  LAFLEUR, David, W. ,  MOORE, Paul, A. ,  OLSEN, Henrik, S. ,  ROSEN, Craig, A. ,  RUBEN, Steven, A. ,  SOPPET, Daniel, R. ,  YOUNG, Paul, E. ,  WEI, Ping ,  FLORENCE, Kimberly, A.

IPC分类号： C07K14/47 ,  C12N5/10 ,  C12N5/16 ,  C12N15/12 ,  C12N15/63 ,  C12N15/64

CPC分类号： C07K14/47

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

公开(公告)号：EP1206573A1

公开(公告)日：2002-05-22

申请号：EP00939504.7

申请日：2000-06-02

申请人： HUMAN GENOME SCIENCES, INC.

发明人： RUBEN, Steven, M. ,  BIRSE, Charles, E. ,  DUAN, Roxanne, D. ,  SOPPET, Daniel, R. ,  ROSEN, Craig, A. ,  SHI, Yanggu ,  LAFLEUR, David, W. ,  OLSEN, Henrik, S. ,  EBNER, Reinhard ,  FLORENCE, Kimberly, A. ,  NI, Jian ,  YOUNG, Paul, E.

IPC分类号： C12Q1/68 ,  C07H21/02

CPC分类号： C07K14/47 ,  A61K38/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

公开(公告)号：EP1124850A1

公开(公告)日：2001-08-22

申请号：EP99972222.6

申请日：1999-10-27

申请人： HUMAN GENOME SCIENCES, INC.

发明人： NI, Jian ,  RUBEN, Steven, M. ,  OLSEN, Henrik, S. ,  YOUNG, Paul, E. ,  KENNY, Joseph, J. ,  MOORE, Paul, A. ,  WEI, Ying-Fei ,  GREENE, John, M.

IPC分类号： C07K14/435 ,  C12N15/12

CPC分类号： C12N9/6424 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/70503 ,  C07K14/70546

摘要： The present invention relates to 12 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

公开(公告)号：EP1078046A1

公开(公告)日：2001-02-28

申请号：EP99921691.4

申请日：1999-05-06

申请人： Human Genome Sciences, Inc.

发明人： RUBEN, Steven, M. ,  FLORENCE, Kimberly ,  NI, Jian ,  ROSEN, Craig, A. ,  CARTER, Kenneth, C. ,  MOORE, Paul, A. ,  OLSEN, Henrik, S. ,  SHI, Yang-gu ,  YOUNG, Paul, E. ,  WEI, Fing-Fei ,  BREWER, Laurie A. ,  SOPPET, Daniel, R. ,  LAFLEUR, David, W. ,  ENDRESS, Gregory, A. ,  EBNER, Reinhard

IPC分类号： C12N15/00 ,  C12N15/12 ,  C07K14/00 ,  C07K14/435

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.