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公开(公告)号：EP2115461A1
公开(公告)日：2009-11-11
申请号：EP08701719.0
申请日：2008-01-18
发明人： LAINE, Jarmo , SATOMAA, Tero , NATUNEN, Jari , HEISKANEN, Annamari , BLOMQVIST, Maria , OLONEN, Anne , SAARINEN, Juhani , TIITINEN, Sari , IMPOLA, Ulla , AITIO, Olli , VALMU, Leena , NATUNEN, Suvi , SALO, Hanna
CPC分类号： C07K16/28 , C07K16/2896 , C07K16/44 , G01N33/56966 , G01N2400/38
摘要： The invention describes reagents and methods for speficic binders to glycan structures of stem cells. Furthermore the invention is directed to screening of additional binding reagents against specific glycan epitopes on the surfaces of the stem cells. The preferred binders of the glycans structures includes proteins such as enzymes, lectins and antibodies.
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2.发明公开NOVEL CARBOHYDRATE FROM HUMAN CELLS AND METHODS FOR ANALYSIS AND MODIFICATION THEREOF 审中-公开新碳水化合物从分析及修改它的人类细胞和方法
公开(公告)号：EP2115460A1
公开(公告)日：2009-11-11
申请号：EP08701717.4
申请日：2008-01-18
发明人： LAINE, Jarmo , SATOMAA, Tero , NATUNEN, Jari , HEISKANEN, Annamari , BLOMQVIST, Maria , OLONEN, Anne , SAARINEN, Juhani , TIITINEN, Sari , IMPOLA, Ulla , AITIO, Olli , VALMU, Leena , ANDERSON, Heidi , PITKÄNEN, Virve , PARTANEN, Jukka , JAATINEN, Taina
CPC分类号： G01N33/5308 , C12N5/0606 , C12N5/0647 , C12N2500/34 , G01N2400/38
摘要： The invention describes reagents and methods for specific binders to glycan structures of stem cells. Furthermore the invention is directed to screening of additional binding reagents against specific glycan epitopes on the surfaces of the stem cells. The preferred binders of the glycans structures includes proteins such as enzymes, lectins and antibodies.
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公开(公告)号：EP2108043A1
公开(公告)日：2009-10-14
申请号：EP08701716.6
申请日：2008-01-18
发明人： LAINE, Jarmo , SATOMAA, Tero , NATUNEN, Jari , HEISKANEN, Annamari , BLOMQVIST, Maria , OLONEN, Anne , SAARINEN, Juhani , TIITINEN, Sari , IMPOLA, Ulla , MIKKOLA, Milla , VALMU, Leena , TIITTANEN, Minna
CPC分类号： C12N5/0606 , C12N5/0647 , C12N5/0663 , C12N5/0665 , C12N2501/59 , C12N2501/90
摘要： The present invention provides methods and mate rials to modulate and grow stem cells by contacting stem cells with a binder recognizing te rminal glycan structures of stem cells. The modulation can be morphological change, change in differentiation status, biological status or adherence. The materials provided in the present invention are also useful to screen such a binding agents and binders.
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4.发明公开ENZYMATICAL MODIF ICATION OF CELL GLYCOSYLATION USING SERUM ALBUMIN AND DIVALENT CATIONS 审中-公开ZELLGLYKOSYLIERUNG BASIS血清白蛋白和二价阳离子的酶法改性
公开(公告)号：EP2318540A1
公开(公告)日：2011-05-11
申请号：EP09797548.6
申请日：2009-07-16
CPC分类号： C12N5/0006 , A61K2035/124 , C12N5/0663 , C12N5/0665 , C12N9/1051 , C12N2501/70 , C12N2501/724 , C12P21/005
摘要： The invention is directed to a method and kit to control and modify the status of cells, such as human stem cells, by changing their glycosylation, in particular sialylation and fucosylation, levels in a reaction condition where culture medium reagents, such as divalent cations, are present and cells are kept non-adherent. The invention is further directed to novel stem cells, the glycosylation of which has been specifically altered.
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公开(公告)号：EP2132566A1
公开(公告)日：2009-12-16
申请号：EP08718563.3
申请日：2008-03-07
发明人： NATUNEN, Suvi , SATOMAA, Tero , NATUNEN, Jari , VALMU, Leena , PITKÄNEN, Virve
CPC分类号： G01N33/5308 , G01N33/56966 , G01N2400/38
摘要： The invention is directed to the analysis of novel acidic glycan markers of several types of human cells. The analysis is performed by mass spectrometry or specific binder molecules.
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6.发明公开USE OF A PROTEOLYTIC ENZYME FOR THE MODIFICATION OF THE CELL SURFACE OF A STEM CELL 审中-公开VERWENDUNG EINES PROTEOLYTISCHEN ENZYMS ZURVERÄNDERUNGDERZELLOBERFLÄCHEEINER STAMMZELLE
公开(公告)号：EP2556144A1
公开(公告)日：2013-02-13
申请号：EP11719588.3
申请日：2011-04-06
IPC分类号： C12N5/00
CPC分类号： C12N5/0665 , A61K35/12 , C12N5/0006 , C12N5/0663 , C12N2501/734 , C12N2509/00
摘要： The present invention relates to a stem cell and/or a population thereof having a specific profile of cell surface proteins and/or proteoglycans. The present invention also relates to use of a proteolytic enzyme in the modification of the cell surface of a stem cell. The present invention further relates to a method of modifying the cell surface of a stem cell by treatment with a proteolytic enzyme.
摘要翻译： 本发明涉及具有细胞表面蛋白和/或蛋白聚糖特异性特征的干细胞和/或其群体。 本发明还涉及蛋白水解酶在干细胞的细胞表面的修饰中的用途。 本发明还涉及通过用蛋白水解酶处理来修饰干细胞的细胞表面的方法。
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7.发明公开A METHOD OF EVALUATING THE INTEGRITY OF THE PLASMA MEMBRANE OF CELLS BY DETECTING GLYCANS FOUND ONLY INTRACELLULARLY 审中-公开评估方法质膜细胞的完整性仅INTREZELLULÄR经过验证的聚糖
公开(公告)号：EP2316028A1
公开(公告)日：2011-05-04
申请号：EP09797547.8
申请日：2009-07-16
发明人： HIRVONEN, Tia , KOTOVUORI, Annika , PITKÄNEN, Virve , NATUNEN, Suvi , NYSTEDT, Johanna , TIITINEN, Sari , VALMU, Leena , NATUNEN, Jari
IPC分类号： G01N33/53 , G01N33/563 , G01N33/577 , C07H13/00
CPC分类号： G01N33/5308 , G01N33/56966 , G01N2400/12 , G01N2400/38
摘要： The invention describes novel reagents that can be applied for analysis of the quality of human cells. The method evaluates the integrity of the plasma membrane of the cells by detecting novel glyco structures found only intracellularly. The method can be applied, for example, to demonstrate exposure of therapeutic cell preparation to potentially harmful conditions. It can also be used as a quality control tool in methods in which intact cell membrane is essential and it can be applied in separation of damaged cells from non- damaged.
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8.发明公开HUMAN MONOCLONAL ANTIBODIES DIRECTED TO SIALYL LEWIS C, SIALYL TN AND N-GLYCOLYLNEURAMINIC ACID EPITOPES AND A METHOD OF ANALYSIS OF STEM CELLS COMPRISING SAID EPITOPES 审中-公开唾液酸基路易斯C，唾液酸Tn和N-羟表位的前瞻性人单克隆抗体以及用于干细胞与这些表位的调查方法
公开(公告)号：EP2209809A1
公开(公告)日：2010-07-28
申请号：EP08847066.1
申请日：2008-11-10
发明人： LAUKKANEN, Marja-Leena , TAKKINEN, Kristiina , NATUNEN, Jari , SATOMAA, Tero , PARKKINEN, Jaakko , VALMU, Leena , TIITINEN, Sari , NATUNEN, Suvi
IPC分类号： C07K16/28 , C12N15/13 , C12P21/08 , C40B30/04 , G01N33/532 , G01N33/563 , G01N33/577 , C12N5/08 , C12N7/01
CPC分类号： C07K16/3076 , C07K2317/21 , C07K2317/622 , G01N33/56966 , G01N2400/10
摘要： This invention relates to antibody engineering technology. More particularly, the present invention relates to human IgM antibodies and derivatives thereof, which have novel binding specificity with regard to several oligosaccharide sequences and/or xenoantigenic sialic aicd residue. The present invention also relates to processes for making and engineering such novel saccharide and/or NeuGc-binding monoclonal antibodies and to methods for using these antibodies and derivatives thereof in the field of immunodiagnostics, enabling qualitative and quantitative determination of xenoantigenic NeuGc in biological and raw material samples, as well as in immunotherapy, enabling blocking of xenoantigenic NeuGc in patients.
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