公开(公告)号：EP2283013A1

公开(公告)日：2011-02-16

申请号：EP09733572.3

申请日：2009-04-14

申请人： Vertex Pharmaceuticals Incorporated

发明人： WANG, Tiansheng ,  ARONOV, Alexander ,  CORNEBISE, Mark ,  MALTAIS, Francois ,  LEDOBOER, Mark ,  LE TIRAN, Arnaud ,  MARONE, Valerie ,  MESSERSMITH, David ,  COTTRELL, Kevin ,  COME, Jon, H. ,  BOTELA, Gabriel, Martinez

IPC分类号： C07D417/04 ,  C07D513/04 ,  A61K31/428 ,  A61K31/4365 ,  A61P37/00

CPC分类号： C07D513/04 ,  C07D417/04

摘要： The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3K ggr;. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

摘要翻译： 本发明涉及用作PI3K抑制剂的化合物，特别是PI3K ggr。的抑制剂。 本发明还提供了包含所述化合物的药学上可接受的组合物以及使用该组合物治疗各种疾病，病症或障碍的方法。

公开(公告)号：EP2454254A2

公开(公告)日：2012-05-23

申请号：EP10734877.3

申请日：2010-07-16

申请人： Vertex Pharmaceuticals Incorporated

发明人： HENDERSON, James A. ,  MAXWELL, John ,  VAILLANCOURT, Louis ,  MORRIS, Mark ,  GREY, JR., Ronald ,  GIROUX, Simon ,  KONG, Laval Chan Chun ,  DAS, Sanjoy Kumar ,  LIU, Bingcan ,  POISSON, Carl ,  CADILHAC, Caroline ,  BUBENIK, Monica ,  REDDY, T. Jagadeeswar ,  FALARDEAU, Guy ,  YANNOPOULOS, Constantin ,  WANG, Jian ,  PEREIRA, Oswy Z. ,  BENNANI, Youssef L. ,  PIERCE, Albert C. ,  BHISETTI, Govinda Rao ,  COTTRELL, Kevin M. ,  MARONE, Valerie

IPC分类号： C07D401/14 ,  C07D403/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D495/04 ,  A61K31/4184 ,  A61P3/00

CPC分类号： C07K5/06052 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D495/04

摘要： Compounds represented by formula (I) or pharmaceutically acceptable salts and solvates thereof, wherein A, B, B', X, Y, R
1 , R
1 ', R
2 , R
2 ', R
3 , R
3 ', R
5 , R
5 ', R
6 , m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.

公开(公告)号：EP2401273A1

公开(公告)日：2012-01-04

申请号：EP10706860.3

申请日：2010-02-25

申请人： Vertex Pharmaceuticals Incorporated

发明人： ARONOV, Alex ,  COME, Jon ,  COTTRELL, Kevin ,  GREY, Ronald ,  LE TIRAN, Amaud ,  MARONE, Valerie ,  MARTINEZ-BOTELLA, Gabriel ,  MESSERSMITH, David ,  HUCK, Emilie, Porter

IPC分类号： C07D417/04 ,  C07D513/04 ,  C07D417/14 ,  A61K31/4965 ,  A61K31/4427 ,  A61K31/506 ,  A61K31/501 ,  A61P29/00 ,  A61P37/00

CPC分类号： C07D417/14 ,  C07D417/04 ,  C07D513/04

摘要： The present invention relates to compounds useful as inhibitors of P13K, particularly of P13Kgamma. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of several diseases, such as cancer and autoimmune diseases.

公开(公告)号：EP2252618A1

公开(公告)日：2010-11-24

申请号：EP08867722.4

申请日：2008-12-18

申请人： Vertex Pharmaceuticals Incorporated

发明人： LEDEBOER, Mark ,  STEWART, Michelle ,  MESSERSMITH, David ,  DUFFY, John ,  MARTINEZ-BOTELLA, Gabriel ,  COME, Jon ,  GAO, Huai ,  SALITURO, Francesco ,  MARONE, Valerie ,  PIERCE, Albert

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P35/00

CPC分类号： C07D487/04

摘要： The present invention relates to compounds of formula (I) useful as selective inhibitors of JAK2 kinase. The invention also provides pharmaceutical acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various diseases, conditions or disorders. The invention also provides processes for preparing the compounds of the invention.