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1.发明公开TISSUE REPAIR DEVICES UTILIZING SELF-ASSEMBLED MATERIALS 审中-公开GEWEBEREPARATURVORRICHTUNGEN MIT SELBSTORGANISIERTEN MATERIALIEN
公开(公告)号：EP3033117A1
公开(公告)日：2016-06-22
申请号：EP13891849.5
申请日：2013-08-20
发明人： WAGNER, William, D. , LEVI-POLYACHENKO, Nicole , WANG, Rui , ARGENTA, Louis, C. , MORYKWAS, Michael, J.
IPC分类号： A61M1/00
CPC分类号： A61H9/0057 , A61L27/26 , A61L27/50 , A61L27/56 , A61L31/042 , A61L31/047 , A61L31/06 , A61L31/146 , A61L2300/236 , A61L2300/252 , A61L2300/606 , A61L2400/06 , A61L2420/02 , A61L2420/06 , A61L2430/20 , A61M1/0088 , C08L89/00 , C08L5/08
摘要： Porous self-assembling biomaterials comprising silk-fibroin and hyaluronic acid and methods for preparing such biomaterials are disclosed. Devices employing the porous self-assembling biomaterials are also provided.
摘要翻译： 公开了包含丝心蛋白和透明质酸的多孔自组装生物材料和制备这种生物材料的方法。 还提供了采用多孔自组装生物材料的装置。
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公开(公告)号：EP2237812A1
公开(公告)日：2010-10-13
申请号：EP09701384.1
申请日：2009-01-09
发明人： ARGENTA, Louis, C. , CARROLL, David, L. , LEVI, Nicole, H. , LIU, Jie , MORYKWAS, Michael, J. , TATTER, Stephen , WAGNER, William, D.
IPC分类号： A61M1/00
CPC分类号： A61M1/0088 , A61H7/00 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/56 , A61M2207/00 , A61M2210/0693 , B29C47/0076 , B29C64/112 , B29C67/202 , B29K2089/00 , B29K2995/006 , B29L2031/753 , C08L67/04 , C08L5/08
摘要： The present invention relates generally to a device and method for treating tissues of the central nervous system and more particularly, but not exclusively, to a device and method for treating the brain tissue.
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3.发明公开DESIGN OF A CONDUIT FOR PERIPHERAL NERVE REPLACEMENT 审中-公开ENTWURF EINER LEITUNGFÜREINEN PERIPHEREN NERVENERSATZ
公开(公告)号：EP2838607A1
公开(公告)日：2015-02-25
申请号：EP13775894.2
申请日：2013-03-15
发明人： WAGNER, William, D. , LEVI-POLYACHENKO, Nicole , MORYKWAS, Michael,J. , ROSENBALM, Tabitha , ARGENTA, Louis, C.
IPC分类号： A61N1/05
CPC分类号： A61B17/1128 , A61B2017/00004 , A61B2017/00831 , A61B2017/00991 , A61B2017/1132 , A61F2/0077 , A61L27/18 , A61L27/26 , A61L27/446 , A61L27/50 , A61L27/58 , A61L2400/12 , A61L2430/32 , C08G63/12 , C08G63/47 , H01B1/125 , C08L67/00
摘要： A biphasic material and devices comprising the same are provided for the development of conductive conduits that may be used for the treatment of peripheral nerve injury. These devices or conduits are designed such that repeated electric field gradients can be initiated to promote neurite and axonal outgrowth. Conducting conduits using doped synthetic and/or natural polymers create specifically patterned high and low conducting segmented materials, which are mechanically used to produce the electrical properties needed for nerve conduits. These electrical properties stimulate neurite outgrowth and axonal repair following a peripheral nerve transection.
摘要翻译： 为了开发可用于治疗周围神经损伤的导电导管，提供了双相材料和包括该双相材料的装置。 这些装置或管道被设计成可以启动重复的电场梯度以促进神经突和轴突向外生长。 使用掺杂的合成和/或天然聚合物的导管产生特异性图案化的高和低导电分段材料，其被机械地用于产生神经导管所需的电性质。 这些电学性质在周围神经横断后刺激神经突生长和轴突修复。
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4.发明公开
公开(公告)号：EP2313008A1
公开(公告)日：2011-04-27
申请号：EP09798735.8
申请日：2009-07-16
发明人： ARGENTA, Louis, C. , CARROLL, David, L. , LEVI, Nicole, H. , LIU, Jie , MORYKWAS, Michael, J. , JORDAN, James, E. , WAGNER, William, D.
IPC分类号： A61B17/00
CPC分类号： A61B17/00234 , A61B90/06 , A61B2017/00243 , A61B2017/306 , A61B2090/064 , A61F13/00068 , A61F2013/0028 , A61M1/0031 , A61M1/0037 , A61M1/0088 , A61M2210/1082 , A61M2210/125
摘要： A method and apparatus are provided for treating cardiac tissue to modulate ischemic heart tissue with topical sub-atmospheric pressure to minimize cell death and damage.
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5.发明公开NOVEL NANOFIBER-BASED GRAFT FOR HEART VALVE REPLACEMENT AND METHODS OF USING THE SAME 审中-公开新型纳米纤维为主移植治疗心脏瓣膜置换及其使用方法
公开(公告)号：EP2911708A1
公开(公告)日：2015-09-02
申请号：EP13849526.2
申请日：2013-10-25
发明人： WAGNER, William, D. , LEVI-POLYACHENKO, Nicole , WANG, Rui , ARGENTA, Louis, C. , MORYKWAS, Michael, J.
CPC分类号： A61F2/2412 , A61F2/2415 , A61F2/82 , A61K9/70 , A61L27/26 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2400/12 , A61L2430/20 , C08J9/0061 , C08J2389/00 , C08J2389/06 , C08J2467/02 , C08J2489/00 , C08J2489/06 , C08L89/00 , C08L89/06 , C08L2201/06 , C08L2203/02 , C08L2203/12 , C08L2205/02 , C08L2205/03 , Y10T428/298 , C08L31/06
摘要： Nanofiber-based biomaterials containing fibroin for wound repair and tissue replacement and, more particularly, heart valve replacement.
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6.发明授权APPARATUS FOR CARDIAC TISSUE MODULATION BY TOPICAL APPLICATION OF VACUUM TO MINIMIZE CELL DEATH AND DAMAGE 有权心脏组织调制器件通过真空外敷法减小细胞死亡和腐败
公开(公告)号：EP2313008B1
公开(公告)日：2017-04-12
申请号：EP09798735.8
申请日：2009-07-16
发明人： ARGENTA, Louis, C. , CARROLL, David, L. , LEVI, Nicole, H. , LIU, Jie , MORYKWAS, Michael, J. , JORDAN, James, E. , WAGNER, William, D.
CPC分类号： A61B17/00234 , A61B90/06 , A61B2017/00243 , A61B2017/306 , A61B2090/064 , A61F13/00068 , A61F2013/0028 , A61M1/0031 , A61M1/0037 , A61M1/0088 , A61M2210/1082 , A61M2210/125
摘要： A method and apparatus are provided for treating cardiac tissue to modulate ischemic heart tissue with topical sub-atmospheric pressure to minimize cell death and damage.
摘要翻译： 提供了用于治疗心脏组织以调制用局部亚大气压，以使细胞死亡和损伤缺血性心脏组织的方法和装置。
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7.发明公开DEVICES AND METHODS FOR TREATING SPINAL CORD TISSUE 有权VORRICHTUNGEN ZUR BEHANDLUNG VONRÜCKENMARKSGEWEBE
公开(公告)号：EP2205189A1
公开(公告)日：2010-07-14
申请号：EP08837309.7
申请日：2008-10-09
发明人： ARGENTA, Louis, C. , CARROLL, David, L. , LEVI, Nicole, H. , LIU, Jie , MORYKWAS, Michael, J. , TATTER, Stephen , WAGNER, William, D.
IPC分类号： A61F2/44
CPC分类号： A61M1/0088 , A61F13/00021 , A61M1/0023 , A61M2210/1003
摘要： The present invention provides devices and methods that treat damaged spinal cord tissue, such as spinal tissue damaged by disease, infection, or trauma, which may lead to the presence of swelling, compression, and compromised blood flow secondary to interstitial edema.
摘要翻译： 本发明提供了治疗损伤的脊髓组织（例如由疾病，感染或创伤损伤的脊髓组织）的装置和方法，其可导致继发于间质性水肿的肿胀，压缩和受损的血流。
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8.发明公开METHODS AND COMPOSITIONS FOR PRINTING BIOLOGICALLY COMPATIBLE NANOTUBE COMPOSITES OF AUTOLOGOUS TISSUE 审中-公开方法和组合物进行印刷生物相容性纳米管复合材料用自体组织
公开(公告)号：EP2203129A1
公开(公告)日：2010-07-07
申请号：EP08838619.8
申请日：2008-10-14
发明人： CARROLL, David, L. , WAGNER, William, D. , LEVI, Nicole, H. , ARGENTA, Louis , MORYKWAS, Michael
CPC分类号： A61L27/38 , C12N5/0629 , C12N5/0656 , C12N2501/115 , C12N2501/165 , C12N2501/17 , C12N2533/54 , C12N2533/74 , C12N2535/10
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