公开(公告)号：EP2911708A4

公开(公告)日：2016-06-22

申请号：EP13849526

申请日：2013-10-25

Applicant: UNIV WAKE FOREST HEALTH SCIENCES

Inventor： WAGNER WILLIAM D ,  LEVI-POLYACHENKO NICOLE ,  WANG RUI ,  ARGENTA LOUIS C ,  MORYKWAS MICHAEL J

IPC: A61L27/26 ,  A61F2/82 ,  A61L27/54 ,  A61L27/56

CPC classification number: A61F2/2412 ,  A61F2/2415 ,  A61F2/82 ,  A61K9/70 ,  A61L27/26 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2400/12 ,  A61L2430/20 ,  C08J9/0061 ,  C08J2389/00 ,  C08J2389/06 ,  C08J2467/02 ,  C08J2489/00 ,  C08J2489/06 ,  C08L89/00 ,  C08L89/06 ,  C08L2201/06 ,  C08L2203/02 ,  C08L2203/12 ,  C08L2205/02 ,  C08L2205/03 ,  Y10T428/298 ,  C08L31/06

Abstract: Nanofiber-based biomaterials containing fibroin for wound repair and tissue replacement and, more particularly, heart valve replacement.

Abstract translation: 基于纳米纤维生物材料含有创伤修复和组织替代，更具体地说，心脏瓣膜置换素。

公开(公告)号：EP3000489B1

公开(公告)日：2017-04-05

申请号：EP14306475.6

申请日：2014-09-24

Applicant: Sofradim Production

Inventor： Prost, Nicolas ,  Petit, Delphine ,  Bourges, Xavier

IPC: A61L31/10 ,  A61L31/14 ,  C08L89/06

CPC classification number: A61L31/044 ,  A61F2/0063 ,  A61F2/0077 ,  A61F2002/009 ,  A61L27/34 ,  A61L27/58 ,  A61L31/10 ,  A61L31/148 ,  A61L2400/18 ,  A61L2420/08 ,  C08J5/18 ,  C08J7/047 ,  C08J2389/06 ,  C08J2489/06 ,  C08L89/06

Abstract: The present invention relates to a method for preparing a surgical anti-adhesion barrier film comprising the following steps: a°) a first solution, comprising an oxidized collagen is prepared, b) a polyphosphate compound is added to the solution of a) in a quantity so as to obtain a concentration of polyphosphate ranging from 0.007 to 0.7%, by weight, with respect to the total weight of the solution, c) the pH of the solution obtained in b) is adjusted to about 9 by addition of a base or to about 5.1 by addition of an acid, d) a diluted solution is prepared by adding water to solution of c), e) a first layer of solution obtained in c) is casted on an inert support, f) before complete gelation of the layer obtained in d), a second layer, of diluted solution obtained in d) is applied on top of said first layer and let to gelify, g) the gelified first and second layers are dried to obtain a film. The invention further relates to a film obtainable by such a method and to a surgical implant comprising a prosthetic fabric and such a film.

Abstract translation: 本发明涉及一种制备外科抗粘连屏障膜的方法，包括以下步骤：a）制备包含氧化胶原的第一溶液，b）将多磷酸盐化合物加入到a）的溶液中 以获得相对于溶液的总重量为0.007〜0.7重量％的多磷酸盐浓度，c）将b）中得到的溶液的pH调节至约9，加入碱 或通过加入酸至约5.1，d）通过向c）溶液中加入水制备稀释的溶液，e）将c）中得到的第一层溶液浇铸在惰性载体上，f）在完全凝胶化之前 将d）中得到的稀释溶液d）中得到的第二层施加在所述第一层的顶部并使其凝胶化，g）将凝胶化的第一和第二层干燥以获得膜。 本发明还涉及通过这种方法可获得的膜和包括假体织物和这种膜的手术植入物。

公开(公告)号：EP2351779A1

公开(公告)日：2011-08-03

申请号：EP10305093.6

申请日：2010-01-27

Applicant: BIOSPHERE MEDICAL, INC. ,  Biosphere Medical, S.A.

Inventor： Krom, James ,  Reb, Philippe ,  Marion, Pierre ,  De Gioannis, Barbara

IPC: C08F2/44 ,  C08L33/26 ,  A61L27/38

CPC classification number: A61L24/043 ,  A61B6/504 ,  A61K9/16 ,  A61K9/1682 ,  A61K38/39 ,  A61L24/06 ,  A61L2430/36 ,  C08F2/44 ,  C08F220/54 ,  C08J3/246 ,  C08J2333/26 ,  C08J2389/00 ,  C08J2489/06 ,  C08L33/26 ,  C08F222/385

Abstract: Provided herein, for example, are microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Also provided are methods of producing microspheres comprising a copolymer comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bisacrylamide monomer unit. Further provided herein, for example, are compositions comprising the microspheres and methods of using the microspheres and compositions thereof.

Abstract translation: 例如，本文提供了包含明胶或明胶替代物和N-三羟甲基甲基丙烯酰胺单体单元，二乙基氨基乙基丙烯酰胺单体单元和N，N-亚甲基双丙烯酰胺单体单元的共聚物的微球。 还提供了制备包含明胶或明胶替代物的共聚物和N-三羟甲基甲基丙烯酰胺单体单元，二乙基氨基乙基丙烯酰胺单体单元和N，N-亚甲基双丙烯酰胺单体单元的共聚物的微球的方法。 本文进一步提供的是包含微球体的组合物和使用微球体及其组合物的方法。

公开(公告)号：EP3189095A1

公开(公告)日：2017-07-12

申请号：EP15781421.1

申请日：2015-09-02

Applicant: Universita' Degli Studi di Pisa ,  Società Generale per la Gestione del Polo Tecnologico Conciario Società Consortile a responsabilità limitata (PO.TE.CO. S.c.r.l)

Inventor： VITOLO, Sandra ,  PUCCINI, Monica ,  SEGGIANI, Maurizia ,  CASTIELLO, Domenico

IPC: C08J5/18 ,  C08L67/04 ,  C08L89/00 ,  C08L89/04 ,  C08L89/06 ,  C08J11/10 ,  B29C67/00

CPC classification number: C08L89/00 ,  B33Y70/00 ,  C08J5/18 ,  C08J2367/04 ,  C08J2489/06 ,  C08L67/04 ,  C08L89/04 ,  C08L89/06 ,  C08L2201/06 ,  C08L2203/16 ,  C08L2205/18

Abstract: The present invention refers to thermoplastic polymer compositions, highly biodegradable, based on polycaprolactone and a proteic hydrolysate material, that are useful for the quick prototyping with 3D printers and for the manufacture of semi-finished products in the form of filaments, pellets and thin films by hot extrusion.

Abstract translation: 本发明涉及热塑性聚合物组合物，其基于聚己内酯和蛋白质水解产物材料是高度可生物降解的，其可用于利用3D打印机的快速原型制造以及用于制造长丝，丸粒和薄膜形式的半成品 通过热挤压。

公开(公告)号：EP2696851A4

公开(公告)日：2014-10-08

申请号：EP12771498

申请日：2012-04-12

Applicant: UNIV CALIFORNIA

Inventor： LANCE KEVIN D ,  DESAI TEJAL A ,  STEEDMAN MARK RORY ,  BHISITKUL ROBERT B ,  BERNARDS DANIEL A

IPC: A61K9/00

CPC classification number: A61K9/0048 ,  A61F9/0017 ,  A61K9/0051 ,  A61K9/2086 ,  A61K9/7007 ,  A61K31/436 ,  A61K47/34 ,  A61K47/42 ,  B82Y30/00 ,  B82Y40/00 ,  C08J5/18 ,  C08J2300/16 ,  C08J2367/04 ,  C08J2489/06

Abstract: Multilayer thin film devices that include a bioactive agent for elution to the surrounding tissue upon administration to a subject are provided. The multilayer thin film devices are useful as medical devices, such as ocular devices. Also provided are methods and kits for localized delivery of a bioactive agent to a tissue of a subject, and methods of preparing the subject devices. The multilayer thin film medical device includes a first layer, a bioactive agent and a second layer. The first and the second layers may be porous or non-porous. The devices have a furled structure, suitable for administration to a subject.

公开(公告)号：EP2673360A2

公开(公告)日：2013-12-18

申请号：EP12704688.6

申请日：2012-02-09

Applicant: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. ,  Hochschule Regensburg ,  Julius-Maximilians-Universität Würzburg

Inventor： PROBST, Jörn ,  BÖSE, Holger ,  RABINDRANATH, Raman ,  SCHLUNCK, Günther ,  MONKMANN, Gareth ,  CHAMONINE, Mikhail ,  FORSTER, Eva ,  MAYER, Matthias ,  BENTZ, Alexander

IPC: C12N11/08 ,  C12N13/00 ,  C12M1/42 ,  C10M171/00

CPC classification number: C12N11/08 ,  C08J7/047 ,  C08J2300/14 ,  C08J2300/26 ,  C08J2333/26 ,  C08J2383/04 ,  C08J2489/00 ,  C08J2489/06 ,  C12M35/04 ,  C12M35/06 ,  C12N13/00

Abstract: The invention relates to biocompatible, soft, magneto-active polymers (MAP), the elasto-mechanical properties of which can be adjusted by a magnetic field. The invention further relates to special magnetic field systems for locally controlling the MAP and moving, separating, controlling, and influencing biological cells on the surface of the MAP material.

Abstract translation: 本发明涉及一种生物相容的，软的，磁活性聚合物（MAP），其中的弹性力学性能可以通过磁场来调整。 本发明还涉及到特殊的磁场系统用于局部控制MAP和移动，分离，控制，以及材料MAP的表面上影响生物细胞。

公开(公告)号：EP3245246A1

公开(公告)日：2017-11-22

申请号：EP16703010.5

申请日：2016-01-14

Applicant: Nitto Denko Corporation

Inventor： ZHENG, Shijun ,  KATAYAMA, Hiroyuki ,  SIMAVORYAN, Sergey

IPC: C08J7/04 ,  C08J5/18 ,  C08K3/34 ,  C08K5/00 ,  C08K5/07

CPC classification number: C08J7/047 ,  C08F16/06 ,  C08F2500/26 ,  C08F2810/20 ,  C08J3/24 ,  C08J7/123 ,  C08J2367/02 ,  C08J2401/00 ,  C08J2403/00 ,  C08J2405/08 ,  C08J2429/04 ,  C08J2489/00 ,  C08J2489/06 ,  C08K3/042 ,  C08K5/07 ,  C08K5/5415 ,  C08K2201/008 ,  C08K2201/011 ,  C09D129/04 ,  C08K13/02

Abstract: Described herein is a transparent graphene and polymer based nanocomposite barrier film that provides gas, fluid, and/or vapor resistance. Also described is a barrier film where the graphene may be selected from reduced graphene oxide, graphene oxide, and is also functionalized or crosslinked. Also described is a barrier film where there is crosslinking between the graphene and/or the polymers to provide enhanced water resistance. A barrier device is also described that incorporates the barrier film and further comprises a substrate and a protective coating, encompassing the barrier film. Also described are methods for making the aforementioned barrier films and related devices.

公开(公告)号：EP3000489A1

公开(公告)日：2016-03-30

申请号：EP14306475.6

申请日：2014-09-24

Applicant: Sofradim Production

Inventor： Prost, Nicolas ,  Petit, Delphine ,  Bourges, Xavier

IPC: A61L31/10 ,  A61L31/14 ,  C08L89/06

CPC classification number: A61L31/044 ,  A61F2/0063 ,  A61F2/0077 ,  A61F2002/009 ,  A61L27/34 ,  A61L27/58 ,  A61L31/10 ,  A61L31/148 ,  A61L2400/18 ,  A61L2420/08 ,  C08J5/18 ,  C08J7/047 ,  C08J2389/06 ,  C08J2489/06 ,  C08L89/06

Abstract: The present invention relates to a method for preparing a surgical anti-adhesion barrier film comprising the following steps:
a°) a first solution, comprising an oxidized collagen is prepared,
b) a polyphosphate compound is added to the solution of a) in a quantity so as to obtain a concentration of polyphosphate ranging from 0.007 to 0.7%, by weight, with respect to the total weight of the solution,
c) the pH of the solution obtained in b) is adjusted to about 9 by addition of a base or to about 5.1 by addition of an acid,
d) a diluted solution is prepared by adding water to solution of c),
e) a first layer of solution obtained in c) is casted on an inert support,
f) before complete gelation of the layer obtained in d), a second layer, of diluted solution obtained in d) is applied on top of said first layer and let to gelify,
g) the gelified first and second layers are dried to obtain a film.
The invention further relates to a film obtainable by such a method and to a surgical implant comprising a prosthetic fabric and such a film.

公开(公告)号：EP2911708A1

公开(公告)日：2015-09-02

申请号：EP13849526.2

申请日：2013-10-25

Applicant: Wake Forest University Health Sciences

Inventor： WAGNER, William, D. ,  LEVI-POLYACHENKO, Nicole ,  WANG, Rui ,  ARGENTA, Louis, C. ,  MORYKWAS, Michael, J.

IPC: A61L27/24 ,  A61L27/14 ,  A61F2/24 ,  A61F2/82

CPC classification number: A61F2/2412 ,  A61F2/2415 ,  A61F2/82 ,  A61K9/70 ,  A61L27/26 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2400/12 ,  A61L2430/20 ,  C08J9/0061 ,  C08J2389/00 ,  C08J2389/06 ,  C08J2467/02 ,  C08J2489/00 ,  C08J2489/06 ,  C08L89/00 ,  C08L89/06 ,  C08L2201/06 ,  C08L2203/02 ,  C08L2203/12 ,  C08L2205/02 ,  C08L2205/03 ,  Y10T428/298 ,  C08L31/06

Abstract: Nanofiber-based biomaterials containing fibroin for wound repair and tissue replacement and, more particularly, heart valve replacement.

公开(公告)号：EP2696851A1

公开(公告)日：2014-02-19

申请号：EP12771498.8

申请日：2012-04-12

Applicant: The Regents of the University of California

Inventor： LANCE, Kevin D. ,  DESAI, Tejal A. ,  STEEDMAN, Mark Rory ,  BHISITKUL, Robert B. ,  BERNARDS, Daniel A.

IPC: A61K9/00

CPC classification number: A61K9/0048 ,  A61F9/0017 ,  A61K9/0051 ,  A61K9/2086 ,  A61K9/7007 ,  A61K31/436 ,  A61K47/34 ,  A61K47/42 ,  B82Y30/00 ,  B82Y40/00 ,  C08J5/18 ,  C08J2300/16 ,  C08J2367/04 ,  C08J2489/06

Abstract: Multilayer thin film devices that include a bioactive agent for elution to the surrounding tissue upon administration to a subject are provided. The multilayer thin film devices are useful as medical devices, such as ocular devices. Also provided are methods and kits for localized delivery of a bioactive agent to a tissue of a subject, and methods of preparing the subject devices. The multilayer thin film medical device includes a first layer, a bioactive agent and a second layer. The first and the second layers may be porous or non-porous. The devices have a furled structure, suitable for administration to a subject.