摘要:
Fluid may be pumped within a microfluidic channel across a cell/particle sensor using a microscopic resistor. The microscopic resistor may be selectively actuated so as to heat the fluid within the microfluidic channel to a temperature below a nucleation energy of the fluid so as to regulate a temperature of the fluid for at least when the cell/particle sensor is sensing the fluid.
摘要:
The present invention relates to a common-path interferometric scattering imaging system and a method of using such a system, where the system comprises: - illuminating means for emitting an illumination beam (L 0 ); - light collecting means for collecting through a common collection optical path: - a scattered beam (L s ) provided by the light scattering on an object (T) of the illumination beam (L 0 ); and - a reference beam (L r ) provided by the reflection on or transmission through an interface (I) of the illumination beam (L 0 );
- image sensing means (D) for receiving and sensing the collected scattered (L s ) and reference (L r ) beams interfering thereon as an interferometric light signal; - attenuation means arranged in the common collection optical path for attenuating the reference beam (L r ) before it arrives at the image sensing means (D); and - processing means (P) to process data corresponding to the interferometric light signal.
摘要:
The present invention relates to a method for the large-scale high-content analysis of biological samples, implemented in a reversed open microwell system which comprises an array of open microwells, at least one microchannel, at least one input port for reagents and/or for one or more biological samples and at least one output port for them, said input and output ports being in microfluidic communication with one or more of said microchannels, wherein said microchannel has a cross-section area of micrometric dimensions and provides fluid to said microwells, wherein said reversed open microwell system is inserted in an automated management system which comprises the following features: an incubator at controlled temperature, humidity and CO 2 , fluid dispensing system, phase-contrast and fluorescence image acquisition. The present invention further relates to a kit for introducing fluids in a microfluidic device and a system for discharging one or more fluids in a microfluidic device.
摘要:
A preprocessing step is performed in which a concentration information of a cell C1 I in a biological sample is acquired by optically measuring a predetermined cell C1 contained in the biological sample flowing in a flow cell 45, and the biological sample is subjected to concentration adjustment of the cell C1 based on the acquired concentration information to prepare a measurement sample. Even when the concentrations of measurement target cells of the respective biological samples are highly varied, measurement samples suitable for the analysis of the measurement target cells can be favorably prepared, and the measurement target cells can be analyzed accurately.
摘要:
Provided are a cell analyzer, and a cell analysis method. A cell analyzer 1 includes a measurement device 2 for detecting information of each cell from a measurement specimen containing cells harvested from an epithelial tissue, and a data processing device 3 for determining appropriateness of the cell harvesting of parabasal cells and acquiring information related to canceration of the cell based on the information detected by the measurement device 2. The data processing device 3 displays on a display section a dialogue showing "cell harvesting inappropriate" when determined that the harvesting of parabasal cells is inappropriate.
摘要:
A microfluidic sensing device comprises a channel and an impedance sensor within the channel. The impedance sensor comprises a local ground and an electrode within the channel. The local ground and the electrode are to form an electric field region that is elongated along the channel.
摘要:
A microfluidic sensing device comprises a channel and an impedance sensor within the channel. The impedance sensor comprises a local ground and an electrode within the channel. The local ground and the electrode are to form an electric field region that is elongated along the channel.
摘要:
A microfluidic sensing device comprises a channel and an impedance sensor within the channel. The impedance sensor comprises a local ground and an electrode within the channel. The local ground and the electrode are to form an electric field region that is elongated along the channel.
摘要:
Described herein are devices and methods for high throughput purification of particles. In some cases, methods and devices described herein can be used to remove erythrocytes and purify leukocytes and raise the quality of umbilical cord blood and other transplant grafts, thereby significantly improving patient outcomes.