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    METHODS OF DIAGNOSING AND TREATING CANCER
    6.
    发明公开
    METHODS OF DIAGNOSING AND TREATING CANCER 审中-公开
    诊断和治疗癌症的方法

    公开(公告)号：EP3194615A1

    公开(公告)日：2017-07-26

    申请号：EP15760171.7

    申请日：2015-09-07

    申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) ,  Université Paul Sabatier Toulouse III

    发明人： POIROT, Marc ,  POIROT, Sandrine

    IPC分类号： C12Q1/68

    CPC分类号： G01N33/57415 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/743 ,  G01N2333/902

    摘要： The present invention relates to methods for the diagnosis and the treatment of cancer, in particular breast cancer. In particular, the present invention relates to a method of diagnosing cancer in a subject comprising the steps of i) determining the expression level of 11βHSD1 and/or 11βHSD2 in a sample obtained from the subject, ii) comparing the expression level determined at step i) with its predetermined reference value and ii) concluding that the subject suffers from a cancer when the expression level of 11βHSD1 is lower than its predetermined reference value or when the expression level of 11βHSD2 is higher than its predetermined reference value.

    摘要翻译： 本发明涉及诊断和治疗癌症，特别是乳腺癌的方法。 具体而言，本发明涉及诊断受试者中癌症的方法，其包括以下步骤：i）测定​​从受试者获得的样品中11βHSD1和/或11βHSD2的表达水平，ii）比较步骤i中测定的表达水平 ）与其预定的参考值进行比较，并且ii）当11βHSD1的表达水平低于其预定参考值时或者当11βHSD2的表达水平高于其预定参考值时，推断受试者患有癌症。

    COMPATIBLE SOLUTE ECTOINE AS WELL AS DERIVATIVES THEREOF FOR ENZYME STABILIZATION
    9.
    发明公开
    COMPATIBLE SOLUTE ECTOINE AS WELL AS DERIVATIVES THEREOF FOR ENZYME STABILIZATION 有权
    兼容解决ECTOIN及其衍生物的酶稳定化

    公开(公告)号：EP2823052A1

    公开(公告)日：2015-01-14

    申请号：EP13707185.8

    申请日：2013-03-05

    申请人： Roche Diagnostics GmbH ,  F.Hoffmann-La Roche AG

    发明人： CHEMNITIUS, Gabriele ,  GAA, Otto ,  NAGEL, Thomas ,  RECHT, Karl

    IPC分类号： C12Q1/32

    CPC分类号： C12Q1/32 ,  G01N2333/902

    摘要： The present invention is concerned with means and methods for maintaining and preserving enzymatic activity. In particular, the invention relates to a dry composition comprising a dehydrogenase, a redox cofactor, an agent capable of eliciting at least one optical change in an optical property of an indicator reagent in the presence of redox equivalents, an indicator reagent, and at least one compatible solute being ectoine or a derivative thereof. The invention further contemplates a diagnostic test element for the determination of an analyte from a body fluid sample and a method for the manufacture of such a test element. Further envisaged by the present invention is the use of at least one compatibie solute as mentioned above for reducing a decrease of the enzymatic activity of at least one enzyme in a composition under dry conditions. Furthermore, contemplated is a method for determining the presence or amount analyte in a body fluid sample based on the test element according to the invention.

    AMADORIASE HAVING ALTERED SUBSTRATE SPECIFICITY
    10.
    发明公开
    AMADORIASE HAVING ALTERED SUBSTRATE SPECIFICITY 有权
    AMADORIASE MITVERÄNDERTERSUBSTRATSPEZIFITÄT

    公开(公告)号：EP2602318A1

    公开(公告)日：2013-06-12

    申请号：EP11814719.8

    申请日：2011-08-04

    申请人： KIKKOMAN CORPORATION

    发明人： ICHIYANAGI Atsushi ,  HIROKAWA Kozo ,  TANABE Yasuko ,  MASAKARI Yosuke

    IPC分类号： C12N15/09 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/04 ,  C12Q1/26

    CPC分类号： C12N9/0032 ,  C12N1/00 ,  C12N15/63 ,  C12Q1/26 ,  G01N33/723 ,  G01N2333/902

    摘要： This invention provides an amadoriase having high substrate specificity to fructosyl valyl histidine. Such amadoriase comprises substitution of one or more amino acid residues at positions corresponding to amino acids selected from the group consisting of position 98, position 259, position 154, position 125, position 261, position 263, position 106, position 103, position 355, position 96, position 66, position 67, position 70, position 100, position 110, position 113, position 114, and position 156 in the amadoriase derived from the genus Coniochaeta. This invention enables accurate measurement of α-fructosyl valyl histidine derived from the β-chain amino terminus in glycated hemoglobin in the presence of ε-fructosyl lysine.

    摘要翻译： 本发明提供对果糖基缬氨酰组氨酸具有高底物特异性的阿马道里酶。 这种阿马道里酶包括在对应于选自第98位，259位，154位，125位，261位，263位，106位，103位，355位氨基酸的位置上的一个或多个氨基酸残基取代。 位于第59位，位置66，位置67，位置70，位置100，位置110，位置113，位置114和位置156在源自Coniochaeta的阿马多利亚酶。 本发明能够在存在μ-果糖基赖氨酸的情况下，精确测定衍生自糖基化血红蛋白的2-链氨基末端的β-果糖基缬氨酰基组氨酸。