公开(公告)号：EP4401788A1

公开(公告)日：2024-07-24

申请号：EP22809018.9

申请日：2022-10-21

申请人： BioNTech SE ,  Universidad de Sevilla ,  Consejo Superior de Investigaciones Científicas (CSIC)

发明人： MORENO HERRERO, Jorge ,  HAAS, Heinrich ,  ERBAR, Stephanie ,  STAHL, Theo Benjamin ,  GARCIA FERNANDEZ, Jose Manuel ,  BENITO HERNANDEZ, Juan Manuel ,  LOPEZ FERNANDEZ, Jose ,  ORTIZ MELLET, Maria del Carmen ,  DE LA CRUZ RUIZ, Noelia ,  GONZALEZ CUESTA, Manuel ,  AMBULUDI, Egon Jack Jacobus ,  VLATKOVIC, Irena

IPC分类号： A61K47/54 ,  C07H15/14 ,  C07H15/26 ,  A61P31/12 ,  A61K9/00 ,  A61K9/51 ,  A61K47/26

CPC分类号： A61K47/549 ,  A61P31/12 ,  A61K9/0019 ,  A61K9/5123 ,  A61K47/543 ,  C12N15/88

公开(公告)号：EP3950684B1

公开(公告)日：2024-03-20

申请号：EP20784747.6

申请日：2020-03-30

发明人： LI, Yi ,  YU, Tao ,  MAO, Qinghua ,  WU, Chengde ,  CHEN, Shuhui

IPC分类号： C07H15/14 ,  C07D405/12 ,  C07D405/10 ,  A61K31/435 ,  A61K31/40 ,  A61P3/04 ,  A61P3/10

公开(公告)号：EP3712147B8

公开(公告)日：2023-04-26

申请号：EP19735712.2

申请日：2019-01-04

发明人： WU, Chengde ,  MAO, Qinghua ,  LI, Yi ,  YU, Tao ,  CHEN, Shuhui

IPC分类号： C07H15/14 ,  A61K31/351 ,  A61K31/381 ,  A61P3/10

公开(公告)号：EP3466958A1

公开(公告)日：2019-04-10

申请号：EP17802197.8

申请日：2017-05-25

申请人： Crystal Pharmaceutical (Suzhou) Co., Ltd.

发明人： CHEN, Minhua ,  ZHANG, Yanfeng ,  ZOU, Po ,  LIU, Kai ,  ZHANG, Xiaoyu

IPC分类号： C07H15/14 ,  C07H1/06 ,  A61K31/7028 ,  A61P3/10

摘要： The present disclosure relates to novel crystalline forms of a sodium-glucose co-transporter inhibitor drug (Sotagliflozin), processes for preparation and use thereof. The present disclosure also relates to pharmaceutical composition comprises novel crystalline forms of Sotagliflozin and use of novel crystalline forms and pharmaceutical composition of Sotagliflozin for preparing drugs for treating diseases. The crystalline forms provided by the present disclosure have advantages of good stability, relatively low hygroscopicity, suitability for process development and post-treatment, simple processes for preparation, low cost, and has significant value for future drug optimization and development.

公开(公告)号：EP2877481A4

公开(公告)日：2016-04-06

申请号：EP13823249

申请日：2013-07-26

申请人： CALLAGHAN INNOVATION RES LTD ,  COMPTON BENJAMIN JASON ,  HAYMAN COLIN MALCOLM ,  HERMANS IAN FRANCIS ,  LARSEN DAVID SAMUEL ,  PAINTER GAVIN FRANK ,  ANDERSON REGAN JAMES

发明人： COMPTON BENJAMIN JASON ,  HAYMAN COLIN MALCOLM ,  HERMANS IAN FRANCIS ,  LARSEN DAVID SAMUEL ,  PAINTER GAVIN FRANK ,  ANDERSON REGAN JAMES

IPC分类号： C07H15/04 ,  A61K31/7028 ,  A61P3/10 ,  A61P11/06 ,  A61P31/04 ,  A61P35/00 ,  A61P37/02 ,  A61P37/08 ,  C07D309/02 ,  C07H15/14

CPC分类号： C07H15/04 ,  A61K39/39 ,  A61K2039/55511 ,  C07H15/06

摘要： This invention relates to sphingoglycolipid analogs, compositions comprising these compounds, processes for preparing the compounds, and methods of treating or preventing diseases or conditions using the compounds, such as diseases or conditions relating to infection, atopic disorders, autoimmune disease, diabetes or cancer.

摘要翻译： 本发明涉及鞘糖脂类似物，包含这些化合物的组合物，制备该化合物的方法，以及使用该化合物治疗或预防疾病或病症的方法，例如与感染，特应性疾病，自身免疫疾病，糖尿病或癌症有关的疾病或病症。

公开(公告)号：EP2014670A3

公开(公告)日：2010-05-19

申请号：EP08104378.8

申请日：2008-06-11

申请人： Kraft Foods Global Brands LLC

发明人： West, Leslie George ,  Pomerleau, Theresa ,  Matusheski, Nathan V. ,  Ludwig, Cathy Jean ,  Hestekin, Jamie ,  Crowley, Colin ,  Kim, Nam-Cheol

IPC分类号： C07H15/14 ,  C07H1/08 ,  A61K31/7028 ,  A61P35/00

CPC分类号： C07H15/14 ,  C07H1/08

摘要： The present invention relates to a process for producing glucosinolates, particularly glucoraphanin, from cruciferous plants. More particularly, a method is provided for producing glucosinolates from agricultural by-products and waste. The general method comprises providing a mixture of glucosinolate-containing plant material and liquid, heating the mixture to inactivate enzymes in the plant material, contacting the heat inactivated mixture with an anion exchange membrane whereby at least a portion of the glucosinolates are extracted from the liquid and absorbed onto the anion exchange membrane, and releasing the glucosinolates from the anion exchange membrane. Preferably, the extraction and release steps are repeated at least once. The glucosinolates produced by the method of the invention may be incorporated into a variety of food products, pharmaceuticals, and health supplements.

公开(公告)号：EP1408045B1

公开(公告)日：2009-05-27

申请号：EP02743752.4

申请日：2002-06-27

申请人： KAO CORPORATION

发明人： UEMATSU, Rie ,  NAKAJIMA, Fumio ,  YOSHIDA, Masahiro ,  FUKUNAGA, Kyoko ,  HARA, Mariko ,  INOUE, Shintaro ,  NISHIMURA, Shinichiro

IPC分类号： C07H15/14 ,  A61K8/00 ,  A61K31/7028 ,  A61P17/16 ,  A61P43/00

CPC分类号： C07H15/14 ,  A61K8/602 ,  A61Q19/00

摘要： Galactosylceramide analogs represented by the following general formula (1) or (2): (1) (2) wherein X and Y represent each S or O; R 1 and R 2 represent each C 9−35 alkyl or alkenyl; and R 3 represents C 2−30 alkyl or alkenyl. Easily available β−glucocerebrosidase activators, external skin preparations and a method of activating β−glucocerebrosidase whereby the formation of a horny layer penetration barrier can be improved through the activation of β−glucocerebrosidase and, as result, it is expected that skin roughness can be ameliorated.

公开(公告)号：EP1751171A1

公开(公告)日：2007-02-14

申请号：EP05745033.0

申请日：2005-05-20

申请人： Forskarpatent i Syd AB

发明人： NILSSON, Ulf ,  LEFFLER, Hakon ,  CUMPSTEY, Ian

IPC分类号： C07H13/04 ,  C07H5/06 ,  C07H15/04 ,  C07H15/14 ,  C07H15/12 ,  C07H3/04 ,  A61K31/7016 ,  A61K31/7028 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00

CPC分类号： C07H13/04 ,  C07H3/04 ,  C07H5/06 ,  C07H15/04 ,  C07H15/12 ,  C07H15/14

摘要： The present invention relates to novel galactosides and the use of the galactosides as a medicament, as well as for the manufacture of a medicament for treatment of disorders relating to the binding of galactin to receptors in a mammal. Said galectin is preferably galectin-3.

公开(公告)号：EP0640613A1

公开(公告)日：1995-03-01

申请号：EP92906226.3

申请日：1992-03-03

申请人： RIKAGAKU KENKYUSHO ,  MECT CORPORATION

发明人： OGAWA, Tomoya ,  NUNOMURA, Shigeki ,  SUGIMOTO, Mamoru

IPC分类号： C07H15/04 ,  A61K31/70 ,  C07H15/14 ,  C07H15/26 ,  C07H15/18 ,  C07H3/06

CPC分类号： C07H15/04 ,  C07H3/06 ,  C07H15/18 ,  C07H15/26 ,  Y02P20/55

摘要： An oligosialyl-1,2-dialkyl-Sn-glycerol represented by general formula (I) and an intermediate for its synthesis, wherein R¹ groups represent each independently hydrogen or an alkali metal; R² groups represent each independently C₁₄ to C₁₈ alkyl; Ac represents acetyl; and n represents an integer of 0 to 20. The above glycerol can be used as immunopotentiator, antitumor agent, and diagnostic and therapeutic agent for cancer.

摘要翻译： 由通式（I）表示的寡唾液酸-1,2-二烷基-Sn-甘油和其合成中间体，其中R 1各自独立地表示氢或碱金属; R 2基团各自独立地表示C 14至C 18烷基; Ac表示乙酰基; n表示0〜20的整数。上述甘油可以用作免疫增强剂，抗肿瘤剂，癌症用诊断治疗剂。

公开(公告)号：EP0561523A3

公开(公告)日：1993-09-29

申请号：EP93301554.7

申请日：1993-03-01

申请人： Japan Tobacco Inc.

发明人： Kodama, Hisashi, c/o Japan Tobacco Inc. ,  Hashimoto, Hironobu ,  Kajihara, Yasuhiro

IPC分类号： C07H13/04 ,  A61K31/70 ,  A61K47/48 ,  C07H15/14 ,  C07H17/04 ,  C07H15/04

CPC分类号： C07H13/04 ,  A61K47/62 ,  C07H15/04 ,  C07H15/14 ,  C07H17/04

摘要： A sialic acid-containing sugar chains' biosynthesis inhibitor is excellent in suppression of inflammation or allergy. A sialic acid-containing sugar chains' biosynthesis inhibitor comprises as an active ingredient a sugar compound of the formula (1):

wherein R¹ is a hydrogen atom, a substituted or unsubstituted aliphatic hydrocarbon group, a substituted or unsubstituted aromatic hydrocarbon group, a peptide residue or a sugar residue, and R² is a hydrogen atom, a sulfhydryl group, an acyloxy group, an acylthio group, an aryloxy group, an alkyloxy group, a sugar residue or a glycothio residue. The sialic acid-containing sugar chains' biosynthesis inhibitor may be used as a therapeutic agent for inflammation or the like caused by the sialic acid-containing sugar chains.