公开(公告)号：EP2074144A2

公开(公告)日：2009-07-01

申请号：EP07811727.2

申请日：2007-09-05

申请人： Medarex, Inc.

发明人： ZIMMERMAN, Deborah ,  SELBY, Mark ,  SRINIVASAN, Mohan ,  BELL, Alasdair ,  SINGH, Sujata ,  THEOLIS, Richard Jr. ,  LEBLANC, Heidi N. ,  ZENS, Kyra D. ,  SPROUL, Timothy William

IPC分类号： C07K16/00 ,  C07K16/18 ,  C07K16/22 ,  C07K16/26 ,  C07K16/46 ,  C12N15/13 ,  C12N15/63 ,  C12N15/10 ,  C12N15/16 ,  C12N15/22 ,  C12N15/24 ,  C12N15/26 ,  C12N15/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21

CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K16/22 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, which specifically bind to BMP2, BMP4, BMPRlA, BMPRlB, ACTRl, and/or BMPR2 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Also provided are immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention and, optionally, one or more additional therapeutic. The invention also provides methods for treating diseases associated with abnormal bone formation and ossification mediated by BMP2, -BMP4, BMPRlA, BMPRlB, ACTRl5 and/or BMPR2.

公开(公告)号：EP1740210A4

公开(公告)日：2009-03-25

申请号：EP05744084

申请日：2005-03-29

申请人： MEDAREX INC

发明人： GRAZIANO ROBERT ,  CARDARELLI JOSEPHINE M ,  KEMPE THOMAS D ,  CUTTER BETH ,  SRINIVASAN MOHAN

IPC分类号： A61K39/395 ,  C07H21/04 ,  C07K16/28 ,  C07K16/30 ,  C12N5/10 ,  C12N15/00 ,  C12N15/63

CPC分类号： C07K16/3061 ,  A61K2039/505 ,  C07K16/283 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/92

公开(公告)号：EP1691837A4

公开(公告)日：2009-02-11

申请号：EP04813771

申请日：2004-12-10

申请人： MEDAREX INC

发明人： DESHPANDE SHRIKANT ,  HUANG HAICHUN ,  SRINIVASAN MOHAN ,  CARDARELLI JOSEPHINE M ,  WANG CHANGYU ,  PASSMORE DAVID ,  RANGAN VANGIPURAM S ,  LANE THOMAS E ,  KEIRSTEAD HANS S ,  LIU MICHAEL T

IPC分类号： C07K16/24 ,  A61K39/395 ,  A61P31/04 ,  A61P31/12 ,  A61P37/06 ,  C07D20060101 ,  C07K14/52 ,  C07K16/28 ,  C12N5/18

CPC分类号： C07K16/24 ,  A61K2039/505 ,  C07K14/522 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP- 10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.

公开(公告)号：EP1781705A4

公开(公告)日：2008-11-26

申请号：EP05787743

申请日：2005-06-20

申请人： MEDAREX INC

发明人： CARDARELLI JOSEPHINE M ,  WITTE ALISON ,  SRINIVASAN MOHAN

IPC分类号： C07K16/28 ,  C12P21/08

CPC分类号： C07K16/2866 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/76 ,  C07K2317/92

公开(公告)号：EP1963371A2

公开(公告)日：2008-09-03

申请号：EP06840171.0

申请日：2006-12-08

申请人： Medarex, Inc.

发明人： KORMAN, Alan J. ,  SELBY, Mark J. ,  LU, Li-Sheng ,  WITTE, Alison ,  HUANG, Haichun

IPC分类号： C07K16/28 ,  G01N33/53 ,  A61P35/00

CPC分类号： C07K16/2827 ,  A61K47/6849 ,  A61K51/1027 ,  A61K2039/505 ,  C07H21/00 ,  C07K16/30 ,  C07K16/3015 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/40 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/55 ,  C12N15/00 ,  C12N15/09 ,  C12N15/62

摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.

公开(公告)号：EP1907424A2

公开(公告)日：2008-04-09

申请号：EP06786260.7

申请日：2006-06-30

申请人： MEDAREX, INC.

发明人： KORMAN, Alan, J. ,  SELBY, Mark, J. ,  WANG, Changyu ,  SRINIVASAN, Mohan ,  PASSMORE, David, B. ,  HUANG, Haichun ,  CHEN, Haibin

IPC分类号： C07K16/28

CPC分类号： C07K16/2827 ,  A61K45/06 ,  A61K47/6817 ,  A61K47/6825 ,  A61K47/6849 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/2818 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/567 ,  C07K2317/732 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  Y02A50/386 ,  Y02A50/403 ,  Y02A50/407 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/466

摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to PD-Ll with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The disclosure also provides methods for detecting PD-Ll, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-Ll antibodies.

公开(公告)号：EP1899379A2

公开(公告)日：2008-03-19

申请号：EP06785284.8

申请日：2006-06-20

申请人： MEDAREX, INC.

发明人： RAO-NAIK, Chetana ,  KING, David, John ,  LIU, Jie ,  HUANG, Haichun ,  PASSMORE, David, B. ,  BELL, Alasdair, Fraser ,  CARDARELLI, Josephine, M. ,  PAN, Chin ,  THI DO, To, Uyen ,  CHEN, Sharline

IPC分类号： C07K16/28 ,  A61P35/00 ,  A61P35/02

CPC分类号： C07K16/2803 ,  A61K47/6817 ,  A61K47/6825 ,  A61K47/6849 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/732 ,  C07K2317/77 ,  Y02A50/412

摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to CD19 with high affinity. Nucleic acid molecules encoding such CD19 antibodies, expression vectors, host cells and methods for expressing the CD19 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the CD19 antibodies are also provided. Methods for detecting CD19, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma, are disclosed.

摘要翻译： 本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合CD19的人单克隆抗体。 还提供了编码这种CD19抗体的核酸分子，表达载体，宿主细胞和用于表达CD19抗体的方法。 还提供了免疫偶联物，双特异性分子和包含CD19抗体的药物组合物。 公开了用于检测CD19的方法，以及用于治疗各种B细胞恶性肿瘤（包括非霍奇金淋巴瘤）的方法。

公开(公告)号：EP1896582A1

公开(公告)日：2008-03-12

申请号：EP06746353.9

申请日：2006-05-02

申请人： ONO PHARMACEUTICAL CO., LTD. ,  MEDAREX, INC.

发明人： KORMAN, Alan, J. ,  SRINIVASAN, Mohan ,  WANG, Changyu ,  SELBY, Mark, J. ,  CHEN, Bing ,  CARDARELLI, Josephine, M.

IPC分类号： C12N15/09 ,  C07K16/28 ,  C12N5/00 ,  C12P21/08 ,  C12Q1/02

CPC分类号： A61K39/39558 ,  A61K39/00 ,  A61K39/3955 ,  A61K47/6849 ,  A61K51/10 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/18 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/2818 ,  C07K16/468 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.

公开(公告)号：EP1854808A3

公开(公告)日：2008-02-27

申请号：EP07009216.8

申请日：1999-03-18

申请人： MEDAREX, INC.

发明人： Murphy, Gerald P. ,  Holmes, Eric H. ,  Boynton, Alton L. ,  Tino, William Thomas

IPC分类号： C07K14/00 ,  C07K16/00

CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K16/28 ,  C07K2317/34 ,  C12N2799/026 ,  Y10S435/81

摘要： The present invention relates to monoclonal antibodies that bind to the extracellular domain of prostate-specific membrane antigen (PSMA), hybridoma cell lines producing the antibodies, and methods of using such antibodies for diagnosis and treatment of cancer. In particular, thirty-five monoclonal antibodies reactive with PSMA expressed on the cell surface are exemplified. Additionally, the present invention relates to a novel protein variant (PSM') of PSMA detected by a number of the antibodies of the invention. The hydrolase activity of PSMA and PSM' allows the use of an immunoenzymatic assay for their detection.

公开(公告)号：EP1865991A2

公开(公告)日：2007-12-19

申请号：EP06749436.9

申请日：2006-04-07

申请人： MEDAREX, INC.

发明人： GANGWAR, Sanjeev ,  SUFI, Bilal

IPC分类号： A61K47/48 ,  C07D405/06 ,  A61P35/00

CPC分类号： C07D405/06 ,  A61K47/65 ,  C07D405/14

摘要： The present disclosure provides drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-cleavable substrate conjugates, and to methods of treatment using them.