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公开(公告)号：EP0287110B1
公开(公告)日：1994-03-02
申请号：EP88106040.4
申请日：1988-04-15
发明人： Kondo, Eiji , Kawamura, Yoshimi , Tsuji, Naoki , Matsumoto, Koichi , Kobayashi, Masaaki , Kamigauchi, Toshiyuki , Hayashi, Yoshiyuki , Konishi, Takao
CPC分类号： C07K9/008
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92.发明授权Platinum complexes and antitumor agents containing them as an active ingredient 失效铂复合物和含有它们作为活性成分的抗肿瘤药物。
公开(公告)号：EP0390138B1
公开(公告)日：1994-01-05
申请号：EP90106012.9
申请日：1990-03-29
IPC分类号： C07C59/01 , C07C211/36 , C07F15/00 , A61K31/28
CPC分类号： C07C59/01 , C07C62/02 , C07C62/04 , C07F15/0093
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93.发明授权Benzotriazole derivatives and chiral derivatization reagents for carboxylic acids thereof 失效衍生的苯并三唑衍生物和由其为羧酸的手性衍生物的制备试剂。
公开(公告)号：EP0363964B1
公开(公告)日：1993-12-29
申请号：EP89118988.8
申请日：1989-10-12
IPC分类号： C07D249/20 , G01N21/64 , G01N33/15
CPC分类号： C07D249/20
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94.发明授权Monoclonal antibodies recognizing alpha-hANP and corresponding hybridomas, their preparation and use 失效针对人α-Atrialnatriüretic多肽和相应的杂交瘤，其制备和用途的单克隆抗体。
公开(公告)号：EP0306309B1
公开(公告)日：1993-12-01
申请号：EP88308100.2
申请日：1988-09-01
发明人： Imura, Hiroo , Nakao, Kazuwa , Ishikawa, Eiji , Kono, Masao , Inouye, Ken
IPC分类号： C12P21/08 , C07K15/00 , C12N5/20 , G01N33/577
CPC分类号： G01N33/6893
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公开(公告)号：EP0452145A3
公开(公告)日：1993-03-10
申请号：EP91303256.1
申请日：1991-04-12
发明人： Nagafuzi, Norboru , Tsukada, Takayuki , Shima, Kazuhiro , Takagishi, Yasushi , Suzuki, Yusuke , Tomoda, Yoshitaka , Hayashi, Takashi
CPC分类号： B82Y5/00 , A61K9/1641 , A61K9/5073 , A61K47/6951
摘要： A process for preparing a coated composition comprising a pharmaceutically active substance stable to heat, which comprises centrifugally granualting a mixture comprising said active substance and a first thermomelting material as a binder under heating without using any solvent and coating the resultant granules with a second thermomelting material as a coating material under heating, the melting point of the second thermomelting material being lower than that of the first thermomelting material.
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公开(公告)号：EP0348203B1
公开(公告)日：1993-02-24
申请号：EP89306331.3
申请日：1989-06-23
发明人： Kita, Toru Chisan Mansion Ichijoji 603 , Narumiya, Shuh Sky Mansion 413, 561-4, Komanomachi , Narisada, Masayuki , Watanabe, Fumihiko , Matsumoto, Saichi , Doteuchi, Masami , Mizui, Takuji
IPC分类号： C07C323/22 , A61K31/10
CPC分类号： C07C323/52 , Y02P20/55 , Y10S514/824
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公开(公告)号：EP0522868A1
公开(公告)日：1993-01-13
申请号：EP92306347.3
申请日：1992-07-10
CPC分类号： C07K14/70571 , C07K14/72
摘要： DNA encoding an endothelin receptor shown in SEQ ID NO: 1 or 2 in the Sequence Listing is isolated from cDNA which is prepared from poly(A)⁺RNA derived from a human placenta. In addition, an expression vector containing the DNA and a transformant containing the expression vector are obtained. An endothelin receptor is obtained by culturing this transformant. A receptor shown in SEQ ID NO: 1 is an ET A -receptor which has a high affinity for endothelins 1 and 2, especially for the endothelin 1. A receptor shown in SEQ ID NO: 2 is an ET B -receptor which has an affinity for endothelins 1, 2 and 3 with no selectivity.
摘要翻译： 从序列表中SEQ ID NO：1或2所示的内皮素受体编码的DNA从由人胎盘的聚（A）+ RNA制备的cDNA中分离。 此外，获得含有DNA的表达载体和含有表达载体的转化体。 通过培养该转化体获得内皮素受体。 SEQ ID NO：1所示的受体是对内皮素1和2具有高亲和力的ETA-受体，特别是内皮素1。SEQ ID NO：2所示的受体是ETB受体，其对 内皮素1,2和3，没有选择性。
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公开(公告)号：EP0267378B1
公开(公告)日：1992-11-04
申请号：EP87112029.1
申请日：1987-08-19
IPC分类号： A61K31/12 , A61K31/215 , A61K31/22 , A61K31/255 , A61K31/34 , A61K31/26 , A61K31/335
CPC分类号： A61K31/12 , A61K31/215 , A61K31/22 , A61K31/255 , A61K31/26 , A61K31/335 , A61K31/34
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公开(公告)号：EP0467647A3
公开(公告)日：1992-08-12
申请号：EP91306442.4
申请日：1991-07-16
发明人： Kubota, Tadatoshi , Kume, Masaharu
IPC分类号： C07D501/59 , A61K31/545
CPC分类号： C07D249/04 , C07D501/00 , Y02P20/55
摘要： A novel thioalkylthio cephalosporin antibiotic compound of formula I :
wherein Acyl is C 1 - C 12 acyl ; Het is optionally substituted monocyclic heteroaromatic group containing one or more hetero atoms ; R 1 is a single bond or C 1 - C 4 alkylene ; R 2 is a straight or branched C 1 - C 4 alkylene ; X is a sulfur atom or sulfoxide group ; and Y is a hydrogen atom or methoxy group, or a pharmaceutically acceptable salt or an amino-, carboxy- and/or hydroxy-protected derivative thereof, a formulation containing the same and a method for treating bacterial infections.-
100.发明公开A radioactive iodine compound for labeling an antibody 失效Radioaktive Jodverbindung zur Markierung vonAntikörpern。
公开(公告)号：EP0488778A2
公开(公告)日：1992-06-03
申请号：EP91311108.4
申请日：1991-11-29
发明人： Yamauchi, Akira , Ueda, Akira , Kono, Masao , Igano, Kenichi , Inouye, Ken
IPC分类号： C07D207/452 , G01N33/58
CPC分类号： C07D207/40 , G01N33/534
摘要： The radioactive iodine compound of this invention or an intermediate for preparing the compound is represented by the following formula (I):
wherein R is H or ¹²⁵I.
The radioactive compound can readily introduce a radioactive isotope element such as ¹²⁵I into an antibody molecule without damaging the activity of the antibody molecule. Therefore, the compound can preferably be used to label an antibody of immunoradiometric assay, and allow a higher degree of measurement sensitivity.摘要翻译： 本发明的放射性碘化合物或用于制备化合物的中间体由下式（I）表示：其中R为H或<1> 2 <5> I的
。 放射性化合物可以容易地将一种放射性同位素元素例如1 <2> 5 I引入抗体分子中而不损害抗体分子的活性。 因此，化合物可以优选用于标记免疫放射测定的抗体，并且允许更高程度的测量灵敏度。
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