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210 条记录 (耗时 0.014 秒)

    Semipermeable nerve guidance channels
    92.
    发明公开
    Semipermeable nerve guidance channels 失效
    HalbdurchlässigerFührungskanalfürNerven。

    公开(公告)号：EP0286284A1

    公开(公告)日：1988-10-12

    申请号：EP88302678.3

    申请日：1988-03-25

    申请人： BROWN UNIVERSITY RESEARCH FOUNDATION

    发明人： Valentini, Robert F. ,  Aebischer, Patrick ,  Galletti, Pierre M.

    IPC分类号： A61F2/00

    CPC分类号： A61B17/1128 ,  A61B17/00491 ,  A61B17/11 ,  A61B2017/00004 ,  A61F2002/30235 ,  A61F2230/0069 ,  A61L27/26 ,  A61L31/04 ,  A61L2430/32

    摘要： Medical devices and methods employing semipermeable materials, such as acrylic copolymers, polyurethane isocyanate, and other biocompatible semipermeable polymers, are disclosed for use as guidance channels in regenerating nerves. The devices can be formed by tubular semipermeable conduits adapted to receive the ends of a severed or damaged nerve. The tubular conduits define lumens through which axons can regenerate to restore motor and/or sensory functions. The guidance materials are chosen such that they are capable of allowing the diffusion of nutrients and other metabolites to the regenerating nerve site while excluding fibroblasts and other scar-forming cells. In particular, tubular channels which have a smooth inner surface and longitudinally oriented trabeculae result in significantly larger regenerated nerve cables and higher numbers of regenerated myelinated axons.

    摘要翻译： 公开了使用半透性材料的医疗装置和方法，例如丙烯酸共聚物，聚氨酯异氰酸酯和其它生物相容性半透性聚合物，用作再生神经中的引导通道。 装置可以由适于接收切断或损伤的神经的端部的管状半透管形成。 管状导管定义腔，通过其可以再生轴突以恢复运动和/或感觉功能。 选择指导材料，使得它们能够允许营养物和其它代谢物扩散到再生神经部位，同时排除成纤维细胞和其他瘢痕形成细胞。 特别地，具有光滑的内表面和纵向取向的小梁的管状通道导致明显更大的再生神经电缆和更多数量的再生有髓轴突。

    TREATMENT OF METASTASIS
    93.
    发明公开
    TREATMENT OF METASTASIS 失效
    治疗转移。

    公开(公告)号：EP0167567A1

    公开(公告)日：1986-01-15

    申请号：EP85900412.0

    申请日：1984-12-13

    申请人： BROWN UNIVERSITY RESEARCH FOUNDATION

    发明人： AGARWAL, Kailash, C. ,  PARKS, Robert, E., Jr.

    IPC分类号： A61K31

    CPC分类号： A61K31/35

    摘要： Un procédé de réduction de l'incidence de métastases chez des patients victimes de tumeurs consiste à administrer de la forskoline ou ses analogues, puissants inhibiteurs de l'agglutination de thrombocytes. Les composés de forskoline sont définis généralement comme diterpénoïdes de labdane et présentent la formule générale (I). Ces composés peuvent être administrés seuls ou en combinaison avec d'autres inhibiteurs de l'agglutination de thrombocytes.

    Catheter
    95.
    发明公开
    Catheter 失效
    导管。

    公开(公告)号：EP0074114A1

    公开(公告)日：1983-03-16

    申请号：EP82108224.5

    申请日：1982-09-07

    申请人： BROWN UNIVERSITY RESEARCH FOUNDATION

    发明人： Galletti, Pierre M. ,  De Rossi, Danilo Emilio ,  Dario, Paolo

    IPC分类号： A61B5/00 ,  A61B5/02 ,  A61M25/00

    CPC分类号： G01L9/008 ,  A61B5/02156 ,  A61B5/03 ,  A61M25/005 ,  A61M2025/0002

    摘要： A catheter (12) including a support (40) suitable for insertion into a body organ, a transducer (50) carried by the support, the transducer (50) including a flexible piezoelectric polymeric membrane (52), and a pair of surface electrodes (54, 56) mounted on the membrane (52), the support (40) including a rigid portion defining a flexure cavity (58) inside the catheter (12), the membrane (52) being mounted on the rigid support portion (40) to permit free flexing of the membrane (52) into and out of the cavity (58), one surface of the membrane (52) communicating with the cavity (58), the other surface of the membrane (52) being exposed to the exterior of the catheter (12) to receive and flex in response to pressure variations in the organ, and means (60, 62) for transmitting from the electrodes (54, 56) to external circuitry electrical signals produced by said flexure.