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91.发明公开3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS 审中-公开3.4 SUBSTITUIERTE PIPERIDINDERIVATE ALS RENININHIBITOREN
公开(公告)号：EP2300453A1
公开(公告)日：2011-03-30
申请号：EP09749373.8
申请日：2009-05-21
发明人： CHEN, Austin Chih-Yu , DUBÉ, Daniel , FOURNIER, Pierre-André , GRIMM, Erich L. , LACOMBE, Patrick , LALIBERTÉ, Sébastien , MACDONALD, Dwight , MACKAY, D. Bruce , MCKAY, Daniel James , WU, Tom Yao-Hsiang
IPC分类号： C07D401/04 , A61K31/4709
CPC分类号： C07D401/04 , C07D401/14
摘要： The present invention relates to 3,4-substituted piperidinyl - based renin inhibitor compounds bearing at 4-position lsoqumolone and having the Formula (I) : The invention further relates to pharmaceutical compositions containing said compounds, as well as their use in treating cardiovascular events and renal insufficiency.
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92.发明公开SUBSTITUTED 2-NAPHTHOIC ACIDS AS ANTAGONISTS OF GPR105 ACTIVITY 审中-公开取代的2-NAPHTOESÄURENAS GPR105活性拮抗剂
公开(公告)号：EP2229373A1
公开(公告)日：2010-09-22
申请号：EP08856275.6
申请日：2008-12-01
发明人： BELLEY, Michel , DESCHENES, Denis , FORTIN, Rejean , FOURNIER, Jean-Francois , GAGNE, Sebastien , GAREAU, Yves , GAUTHIER, Jacques, Yves , LI, Lianhai , ROBICHAUD, Joel , THERIEN, Michel , TRANMER, Geoffrey, K. , WANG, Zhaoyin
IPC分类号： C07D333/24 , A61K31/192 , A61K31/381 , A61P3/04 , A61P3/10 , C07C65/11 , C07C65/24 , C07C63/36 , C07C69/76 , C07D317/60 , C07D249/08 , C07D211/34 , C07C317/44 , C07C323/62 , C07C65/30 , C07C65/34 , C07D211/52 , C07D333/34
CPC分类号： C07D211/34 , C07C65/24 , C07C65/30 , C07C65/40 , C07C69/76 , C07C69/94 , C07C317/44 , C07C317/46 , C07C323/62 , C07D211/52 , C07D249/08 , C07D317/60 , C07D333/16 , C07D333/24 , C07D333/34 , C07D487/04
摘要： Substituted 2-naphthoic acids of structural formula I are effective as antagonists of the biological activity of GPR105 protein. They are useful for the treatment, control or prevention of disorders responsive to antagonism of this receptor, such as diabetes, particularly, Type 2 diabetes, insulin resistance, hyperglycemia, lipid disorders, obesity, atherosclerosis, and conditions associated with the Metabolic Syndrome.
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公开(公告)号：EP2076490A4
公开(公告)日：2010-07-28
申请号：EP07815904
申请日：2007-09-24
IPC分类号： C07C317/48 , A61K31/275
CPC分类号： C07C317/48 , C07C2601/02
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公开(公告)号：EP1891003A4
公开(公告)日：2010-07-21
申请号：EP06741585
申请日：2006-05-30
IPC分类号： C07C317/50 , A61K31/275
CPC分类号： C07C317/48 , C07C2601/02
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公开(公告)号：EP2097377B1
公开(公告)日：2010-07-07
申请号：EP07845514.4
申请日：2007-11-14
发明人： DUBE, Daniel , GALLANT, Michel , GRIMM, Erich L. , JUTEAU, Helene , LALIBERTE, Sebastien , WU, Tom Yao-Hsiang
IPC分类号： C07D211/60 , A61K31/451 , A61K31/4545 , A61P9/10 , A61P9/12 , C07D401/04
CPC分类号： C07D211/60 , C07D401/04
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公开(公告)号：EP1893562A4
公开(公告)日：2010-04-28
申请号：EP06761056
申请日：2006-06-14
发明人： OBALLA RENATA
IPC分类号： C07C255/46 , A61K31/16 , A61K31/165 , A61K31/277 , C07C235/34 , C07C237/24 , C07D213/56
CPC分类号： C07C255/46 , C07C235/34 , C07C235/40 , C07C237/24 , C07C2601/02 , C07D213/56
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97.发明公开PAPAIN FAMILY CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES 审中-公开寄生性疾病的治疗木瓜蛋白酶族的半胱氨酸蛋白酶抑制剂
公开(公告)号：EP1909784A4
公开(公告)日：2010-04-21
申请号：EP06761177
申请日：2006-07-24
IPC分类号： A61K31/00 , A61K31/275 , A61P33/00
CPC分类号： A61K31/275 , A61K45/06 , A61K2300/00
摘要： Several parasites responsible for mammalian diseases are dependent on cysteine protease for various life-cycle functions. Inhibition of these proteases can be useful in the treatment of these parasitic diseases, including toxoplasmosis, malaria, African trypanosomiasis, Chagas disease, leishmaniasis or schistosomiasis.
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98.发明公开BICYCLIC HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE 审中-公开双环杂芳族化合物作为抑制剂硬脂酰辅酶A DELTA-9脱氢酶
公开(公告)号：EP2152719A1
公开(公告)日：2010-02-17
申请号：EP08748339.2
申请日：2008-05-22
发明人： LEGER, Serge , DESCHENES, Denis , FORTIN, Rejean , ISABEL, Elise , POWELL, David
IPC分类号： C07D513/04 , A61K31/519 , A61K31/522 , A61P3/00 , C07D473/30 , C07D498/04
CPC分类号： C07D513/04
摘要： Bicyclic heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; Type 2 diabetes; insulin resistance; hyperglycemia; Metabolic Syndrome; neurological disease; cancer; and liver steatosis. Formula (I).
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公开(公告)号：EP1817276A4
公开(公告)日：2009-12-09
申请号：EP05808098
申请日：2005-11-18
IPC分类号： C07C255/46 , A61K31/275 , A61P19/10
CPC分类号： C07C255/46 , C07C2601/02
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公开(公告)号：EP2114971A1
公开(公告)日：2009-11-11
申请号：EP08706319.4
申请日：2008-01-24
发明人： COLUCCI, John , WILSON, Marie-Claire , HAN, Yongxin , DUFRESNE, Claude , BELLEY, Michel , LAU, Cheuk, K. , BAYLY, Christopher
IPC分类号： C07F9/60 , A61K31/662 , A61K31/675 , A61P3/10 , A61P35/00 , C07F9/38 , C07F9/40
CPC分类号： C07F9/60 , A61K31/662 , A61K45/06 , C07F9/3808 , C07F9/3834 , Y02A50/395
摘要： The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown (Formula I) above and methods of treating or preventing PTP-1B mediated diseases, including diabetes.
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