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公开(公告)号：EP2514424A1
公开(公告)日：2012-10-24
申请号：EP10837591.6
申请日：2010-12-14
发明人： KATAYAMA, Akiko , INOO, Katsuyuki
IPC分类号： A61K31/5415 , A61K9/70 , A61K47/18 , A61K47/32 , A61P29/00
CPC分类号： A61K31/5415 , A61K9/7053 , A61K31/245 , A61K2300/00
摘要： An adhesive patch is provided in which piroxicam is formulated as a non-steroidal anti-inflammatory analgesic. In particular, provided is a piroxicam-containing transdermally absorbable adhesive patch in which an absorption promoter to piroxicam is formulated to achieve high anti-inflammatory and analgesic effects without inhibiting releasing of these drugs. The piroxicam-containing transdermally absorbable adhesive patch contains piroxicam as a medicinal component and oxybuprocaine or a pharmaceutically acceptable salt thereof as an absorption promoter. In the piroxicam-containing transdermally absorbable adhesive patch, the content of piroxicam is from 0.1% to 5% by weight to the total weight of a drug-containing plaster and the content of oxybuprocaine or the pharmaceutically acceptable salt thereof is from 1% to 30% by weight to the total weight of the drug-containing plaster.
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公开(公告)号：EP2460524A1
公开(公告)日：2012-06-06
申请号：EP10804110.4
申请日：2010-07-28
发明人： HASUI, Akihiro , MIYAGI, Takamitsu
CPC分类号： A61K31/573 , A61K9/0009 , A61K47/18 , A61K47/32 , A61N1/0428 , A61N1/0432 , A61N1/0448 , A61N1/30
摘要： It is an object of the present inventions to produce a pharmaceutical composition for the iontophoresis wherein a drug stability is excellent, and it is easy to blend and fill up when manufactured and it is possible to manufacture at low cost. A pharmaceutical composition for an iontophoresis according to the present invention, is characterized in that the composition contains a nonionic synthetic polymer, betamethasone sodium phosphate and solvent. Furthermore, in a preferred embodiment of a pharmaceutical composition for an iontophoresis according to the present invention, the composition is characterized in that the nonionic synthetic polymer is polyvinyl alcohol (PVA). Furthermore, in a preferred embodiment of a pharmaceutical composition for an iontophoresis according to the present invention, the composition is characterized in that the mixing amount of the polyvinyl alcohol (PVA) is 0.5 to 30.0 percent by weight.
摘要翻译： 本发明的目的在于制造用于离子电渗疗法的药物组合物，其中药物稳定性优异，并且制造时容易混合和填充，并且可以以低成本制造。 根据本发明的用于离子电渗疗法的药物组合物的特征在于，所述组合物含有非离子合成聚合物，倍他米松磷酸钠和溶剂。 此外，在本发明的离子电渗疗法用药物组合物的优选方式中，其特征在于，非离子性合成高分子为聚乙烯醇（PVA）。 另外，在本发明的离子电渗疗法用药物组合物的优选方式中，其特征在于，聚乙烯醇（PVA）的配合量为0.5〜30.0重量％。
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93.发明公开
公开(公告)号：EP2246054A1
公开(公告)日：2010-11-03
申请号：EP09706430.7
申请日：2009-01-26
CPC分类号： A61K9/7076 , A61K9/0014 , A61K9/7023 , A61K9/7053 , A61K31/4468 , A61K47/06 , A61K47/14 , A61K47/32
摘要： A patch for external use which has a laminate structure comprising a substrate and a pressure-sensitive adhesive layer which contains a styrene/isoprene/styrene block copolymer as the base and further contains a tackifier resin consisting of a rosin resin and at least one other tackifier resin, a softening agent consisting of polybutene and liquid paraffin, a fatty acid ester, and fentanyl, characterized in that the weight ratio of the rosin resin to fentanyl is 1 to 5, the weight ratio of the rosin resin to the whole tackifier resin is 0.1 to 0.6, and the tackifier resin accounts for 30 to 60wt% of the whole pressure-sensitive adhesive layer. The patch is excellent in the permeation of fentanyl through the skin and in storage stability, and is weak in irritation to skin.
摘要翻译： 一种外用贴剂，其具有包含基材和粘合剂层的层叠结构，所述粘合剂层含有苯乙烯/异戊二烯/苯乙烯嵌段共聚物作为基材，并且还含有由松香树脂和至少一种其它增粘剂组成的增粘树脂 树脂，由聚丁烯和液体石蜡组成的软化剂，脂肪酸酯和芬太尼，其特征在于松香树脂与芬太尼的重量比为1〜5，松香树脂与全部增粘树脂的重量比为 0.1〜0.6，增粘树脂占整个压敏粘合剂层的30〜60重量％。 芬太尼通过皮肤渗透和保存稳定性优异，并且对皮肤的刺激性弱。
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公开(公告)号：EP1249239B1
公开(公告)日：2008-05-21
申请号：EP00981741.2
申请日：2000-12-15
发明人： INAMOTO, Yukiko , KAWATA, Mitsuhiro , KAWABATA, Seiichiro , NAKAYAMA, Daisuke , HISAICHI, Shin-ichi , TOKUDA, Masaaki
CPC分类号： A61K9/0014 , A61K9/06 , A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/616 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/26
摘要： Antipruritic agents for external use containing aspirin, which exerts an excellent therapeutic effect on itching with little side effects, as the active ingredient.
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公开(公告)号：EP1170006B8
公开(公告)日：2008-03-19
申请号：EP99959803.0
申请日：1999-12-14
IPC分类号： A61K31/045 , A61K9/70 , A61K9/06 , A61K36/53 , A61K36/534 , A61K36/14 , A61K36/738 , A61K47/10 , A61K47/30 , A61P25/06
CPC分类号： A61K9/7061 , A61K9/06 , A61K31/045 , Y10S514/947 , Y10S514/953
摘要： Drugs having an effect of relieving hemicrania which contain l-menthol and an essential oil exclusively as the active ingredients. More particularly, ointments and patches having an effect of relieving hemicrania to be topically administered for relieving hemicrania which are prepared by blending l-menthol and an essential oil with ointment compositions containing a water-soluble polymer, a polyhydric alcohol and water.
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公开(公告)号：EP1889594A3
公开(公告)日：2008-02-27
申请号：EP07022865.5
申请日：1998-07-14
CPC分类号： A61Q19/00 , A61K8/0208 , A61K8/97 , A61K2800/242 , A61K2800/75
摘要： The present invention relates to aqueous cataplasms containing a watercress extract which are excellent in the humectant effect and also capable of reducing skin irritation and giving a comfortableness of use even if a calefacient is blended. In particular, the present invention provides the aqueous cataplasms containing a watercress extract with which one or more members selected from the group consisting of powdered capsicum, capsicum extract, capsicum tincture, capsaicin and nonanoic acid vanillylamide can be blended as calefacients.
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公开(公告)号：EP1833471A1
公开(公告)日：2007-09-19
申请号：EP04807500.6
申请日：2004-12-15
IPC分类号： A61K9/70 , A61K31/245
CPC分类号： A61K31/24 , A61K9/7053 , A61K9/7076 , A61K31/245 , A61K47/14 , A61K47/18
摘要： The present invention provides to patches having excellent skin-permeability and therapeutic effect by the drug with lower irritation. In an external patch in which an adhesive layer containing an adhesive base and a drug are laminated with a backing, the external patch wherein the adhesive base contains 5-50 % by weight of synthetic rubber polymer, 10-60 % by weight of adhesive resin and 25-60 % by weight of liquid paraffin, and the drug is etofenamate. According to the present invention, there is obtainable the patches having excellent skin-permeability and therapeutic effect by the drug with lower irritation.
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公开(公告)号：EP1632226A1
公开(公告)日：2006-03-08
申请号：EP04745727.0
申请日：2004-06-10
发明人： KONISHI, Tatsuya , ABE, Yasuko , MACHIDA, Yuji
IPC分类号： A61K31/245 , A61K31/125 , A61K9/70 , A61K31/60 , A61K45/00 , A61P29/00
CPC分类号： A61K45/06 , A61K9/7053 , A61K9/7076 , A61K31/125 , A61K31/245 , A61K31/60 , A61K36/534 , A61K36/61 , A61K36/81 , A61K2300/00
摘要： An anti-inflammatory analgesic adhesive patch which has an excellent anti-inflammatory analgesic effect and is reduced in unpleasant irritant feeling during wear. It is characterized by containing, as active ingredients, benzocaine and an ingredient having a counter-irritation effect, wherein the ingredient having a counter-irritation effect comprises one or more members selected from the group consisting of 1-menthol, dl-menthol, dl-camphor, d-camphor, methyl salicylate, glycol salicylate, peppermint oil, eucalyptus oil, capsaicin, capsicum extract, and nonylic acid vanillamide and the benzocaine is contained in an amount of 0.5 to 20 wt.%
摘要翻译： 一种消炎止痛贴剂，其具有优异的消炎镇痛作用，并减少穿着时令人不快的刺激感。 其特征在于含有作为活性成分的苯佐卡因和具有抗刺激作用的成分，其中所述具有抗刺激作用的成分包含选自1-薄荷醇，dl-薄荷醇，dl - 樟脑，d-樟脑，水杨酸甲酯，水杨酸乙二醇酯，薄荷油，桉树油，辣椒碱，辣椒提取物和壬酸香草酰胺，苯佐卡因的含量为0.5-20重量％
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99.发明公开
公开(公告)号：EP1623711A1
公开(公告)日：2006-02-08
申请号：EP04732726.7
申请日：2004-05-13
IPC分类号： A61K31/565 , A61K31/57 , A61K9/70 , A61P3/06 , A61P5/30 , A61P9/10 , A61P15/12 , A61P19/10 , A61P25/28 , A61P29/00
CPC分类号： A61K9/7053 , A61K9/7076 , A61K31/565 , A61K31/57 , A61L15/585 , A61K2300/00 , C08L39/06 , C08L53/02
摘要： An external patch capable of stable prolonged release and transdemtal absorption of active ingredient hormones (estrogens and/or progestogens) contained in a pressure sensitive adhesive layer, which external patch ensures low irritation on the skin. In particular, an external patch comprising a support and, superimposed thereon, a pressure sensitive adhesive layer, characterized in that the pressure sensitive adhesive layer comprises, as indispensable components, 5 to 50 wt.% of styrene/isoprene/styrene block copolymer, 20 to 70 wt.% of tackifier resin, 10 to 60 wt.% of softener and 1 to 20 wt.% of polyvinylpyrrolidone and contains, as an active ingredient, estrogen and/or progestogen.
摘要翻译： 包含在压敏粘合剂层中的活性成分激素（雌激素和/或孕激素）的稳定的延长释放和透过吸收的外部贴剂，该外部贴片确保对皮肤的低刺激性。 特别地，包括支撑体并且叠加在其上的压敏粘合剂层的外部贴片，其特征在于，所述压敏粘合剂层包含5至50重量％的苯乙烯/异戊二烯/苯乙烯嵌段共聚物，20重量％ 至70重量％的增粘树脂，10至60重量％的软化剂和1至20重量％的聚乙烯吡咯烷酮，并且含有作为活性成分的雌激素和/或孕激素。
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100.发明公开THERAPEUTIC AGENT FOR HEMORRHOIDAL DISEASE 审中-公开治疗师WIRKSTOFF ZUR BEHANDLUNG VONHÄMORRHOIDALENERKRANKUNGEN
公开(公告)号：EP1609472A1
公开(公告)日：2005-12-28
申请号：EP04711719.7
申请日：2004-02-17
CPC分类号： A61K31/616 , A61K9/0031
摘要： An external preparation containing acetylsalicylic acid or its pharmaceutically acceptable salt as an active ingredient for treating anal diseases having therapeutic activity on hemorrhoids (internal hemorrhoid, external hemorrhoid), hemorrhoidal disease owing to anal fissure and other anal diseases together with activity on pain and pruritus.
摘要翻译： 含有乙酰水杨酸或其药学上可接受的盐作为有效成分的外用制剂，用于治疗对痔疮（内痔疮，外痔疮）具有治疗活性的肛门疾病，由肛裂引起的痔疮疾病以及其他肛门疾病以及对疼痛和瘙痒的活动。
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