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91.发明公开Variants of ADP-Glucose pyrophosphorylase affecting phosphate sensitivity and other parameters 审中-公开磷酸盐灵敏度和影响ADP葡萄糖焦磷酸化酶的变体的其他参数
公开(公告)号：EP2186900A3
公开(公告)日：2010-06-02
申请号：EP10001868.8
申请日：2002-12-03
CPC分类号： C12N9/1241 , C07K2319/00 , C12N15/8245 , C12N15/8261 , C12N15/8271 , C12N15/8273 , Y02A40/146
摘要： The subject invention concerns chimeric AGP subunit proteins and polynucleotides that encode the chimeric proteins. The subject invention provides for mutant AGP enzymes comprising a chimeric subunit of the invention that are less sensitive to inorganic phosphate than wild type AGP enzymes. In one embodiment, the AGP subunit is a small subunit of a plant AGP enzyme. The subject invention also concerns plants comprising a polynucleotide encoding a chimeric AGP subunit protein of the invention. The subject invention also concerns methods for producing a plant comprising a polynucleotide of the present invention. Plants produced according to the invention comprise AGP enzymes that are less sensitive to inorganic phosphate than wild type AGP enzyme.
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92.发明公开SYSTEMS AND METHODS BASED ON RADIATION INDUCED HEATING OR IGNITION OF FUNCTIONALIZED FULLERENES 审中-公开系统和方法与放射线感应加热或点燃功能化富勒烯
公开(公告)号：EP2101910A2
公开(公告)日：2009-09-23
申请号：EP07874293.9
申请日：2007-11-16
发明人： KRISHNA, Vijay , MOUDGIL, Brij , KOOPMAN, Ben
CPC分类号： A61N5/062 , A61N1/403 , A61N5/00 , A61N5/025 , A61N5/0625 , A61N5/10 , A61N2005/0659 , A61N2005/0661 , A61N2005/0663 , A61N2005/067 , B01J19/121 , B01J19/123 , B01J19/125 , B01J19/126 , B01J19/127 , B01J19/128 , B01J19/129 , C06B23/001 , C06C9/00
摘要： A method of irradiating a target region containing at least one fullerene comprising molecule promotes the heating or combustion of the target region. The heating method can be employed in a variety of applications including: selective targeting and destruction of cancer cells, detonation of explosives, ignition of a combustible mixture, photolithographic processes, and writing of optical storage media.
摘要翻译： 照射含有至少一个富勒烯分子，其包含靶区域的方法促进所述目标区域的加热或燃烧。 选择性靶向和肿瘤细胞的破坏，爆炸物引爆，可燃混合物的点火，光刻工艺，和光存储介质的写入：加热方法可以在包括各种应用中。
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公开(公告)号：EP2096112A2
公开(公告)日：2009-09-02
申请号：EP09160649.1
申请日：1997-03-31
IPC分类号： C07D277/10 , C07D417/04 , A61K31/426 , A61K31/4709 , A61P7/00
CPC分类号： C07D417/04 , C07D277/10 , C07D277/12
摘要： Derivatives of 2-(2-Hydroxy aryl)-thiazoline-4-carboxylic acids are useful as chelators of trivalent metals in therapeutic applications.
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公开(公告)号：EP1613204B1
公开(公告)日：2009-08-19
申请号：EP04758954.4
申请日：2004-03-26
发明人： SHAW, Gerry , PIKE, Brian, R. , TULI, Sonal, S.
CPC分类号： G01N33/6896 , C07K16/18 , G01N2333/47 , G01N2800/28
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95.发明公开
公开(公告)号：EP2069391A2
公开(公告)日：2009-06-17
申请号：EP07810893.3
申请日：2007-07-27
CPC分类号： G01N33/6893 , A61K31/203 , A61K38/02 , G01N2500/04 , G01N2800/16 , A61K2300/00
摘要： Methods are disclosed for treating or preventing ophthalmic conditions related to a toxic visual cycle product. Compounds and compositions useful in these methods, either alone or in combination with other therapeutic agents, are also described, along with methods of screening for new agents useful in said the therapeutic and prophylactic methods of the invention.
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公开(公告)号：EP1373488B1
公开(公告)日：2009-04-29
申请号：EP02733846.6
申请日：2002-03-14
CPC分类号： C12N9/1241 , C12N15/8245
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97.发明公开System and method for real-time diagnosis, treatment, and therapeutic drug monitoring 审中-公开系统和Verfahren zur Echtzeitdiagnose，Behandlung und therapeutischerWirkstoffüberwachung
公开(公告)号：EP1990639A1
公开(公告)日：2008-11-12
申请号：EP08161973.6
申请日：2005-02-28
发明人： Melker, Richard J. , Sackellares, James Chris , Gold, Mark S. , Dennis, Donn Michael , Martin, Charles R. , Stewart, Jon D.
IPC分类号： G01N33/543 , G01N33/53 , A61K9/51 , G01N33/50 , G01N33/497 , A61B5/11
CPC分类号： G01N33/50 , A61B5/082 , A61B5/4094 , A61B5/411 , A61B5/4821 , A61M5/142 , A61M5/1723 , A61M16/01 , A61M16/085 , A61M2016/1035 , A61M2230/437
摘要： Systems and methods for diagnosing and/or treating diseases as well as monitoring disease treatment. For diagnosis, the present invention uses nanoparticle-based assemblies, which comprise a nanoparticle; a surrogate marker; and a means for detecting a specific chemical entity. In certain embodiments, nanoparticle-based assemblies include a payload for simultaneous diagnosis and treatment of disease. In further embodiments, a therapeutic drug and therapeutic drug marker are administered to a patient to monitor disease treatment. Bodily fluid samples are analyzed using sensor technology to detect the presence of surrogate and/or therapeutic drug markers to provide an efficient and accurate means for diagnosing a disease and/or monitoring disease treatment.
摘要翻译： 用于诊断和/或治疗疾病以及监测疾病治疗的系统和方法。 为了诊断，本发明使用包含纳米颗粒的基于纳米颗粒的组件; 替代标记 以及用于检测特定化学实体的手段。 在某些实施方案中，基于纳米颗粒的组件包括用于同时诊断和治疗疾病的有效载荷。 在另外的实施方案中，向患者施用治疗药物和治疗药物标记物以监测疾病治疗。 使用传感器技术分析体液样品以检测替代物和/或治疗药物标记物的存在，以提供用于诊断疾病和/或监测疾病治疗的有效和准确的手段。
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98.发明公开METHOD OF ATTACHING AN ANTIMICROBIAL CATIONIC POLYELECTROLYTE TO THE SURFACE OF SUBSTRATE 有权方法为保障抗菌阳离子聚电解质在基板的表面
公开(公告)号：EP1937418A2
公开(公告)日：2008-07-02
申请号：EP06802188.0
申请日：2006-08-22
IPC分类号： B05D7/06
CPC分类号： A01N33/12 , A01N37/12 , A61L2/18 , A61L2/232 , A61L15/46 , A61L2300/208 , A61L2300/216 , A61L2300/404 , A61L2300/80 , A01N25/10 , A01N25/24 , A01N25/34 , A01N2300/00
摘要： A method of bonding an antimicrobial cationic polyelectrolyte to the surface of a substrate is described, wherein the antimicrobial thus attached to the substrate provides the substrate with antimicrobial properties, and at least a portion of the bonded antimicrobial is substantially non- leachable during normal conditions of use and storage. A method of manufacturing an antimicrobial material is described which comprises exposure of the substrate to a solution of antimicrobial cationic polyelectrolyte, followed by drying the exposed substrate thoroughly to impart a non-leaching property to at least a portion of the antimicrobial cationic polyelectrolytes.
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公开(公告)号：EP1909812A2
公开(公告)日：2008-04-16
申请号：EP06800453.0
申请日：2006-07-27
IPC分类号： A61K38/04
CPC分类号： A61K31/11 , A61K31/047 , A61K31/16 , A61K31/19 , A61K31/223 , A61K31/365 , A61K31/395 , A61K31/4015 , A61K31/473 , A61K31/52 , A61K33/02 , A61K45/06 , A61K2300/00
摘要： The invention features compositions and methods comprising at least one compound selected from a proteasomal inhibitor, an autophagy inhibitor, a lysosomal inhibitor, an inhibitor of protein transport from the ER to the Golgi, an Hsp90 chaperone inhibitor, a heat shock response activator, a glycosidase inhibitor or histone deacetylase inhibitor that are useful for treating or preventing a protein conformation disease in a subject by correcting misfolded proteins in vivo. The compositions and methods can further comprise an 11-cis-retinal or 9-cis-retinal compound. Examples of protein conformation disorders and/or diseases may include retinitis pigmentosa, age-related macular degeneration, glaucoma, corneal dystrophies, retinoschises, Stargardt's disease, autosomal dominant druzen, Best's macular dystrophy, αl -antitrypsin deficiency, cystic fibrosis, Huntington's disease, Parkinson's disease, Alzheimer's disease, nephrogenic diabetes insipidus, cancer and/or Jacob-Creutzfeld disease.
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公开(公告)号：EP1906874A2
公开(公告)日：2008-04-09
申请号：EP06800450.6
申请日：2006-07-27
发明人： KAUSHAL, Shalesh , GRANT, Maria, G.
IPC分类号： A61F2/00
CPC分类号： A61K38/1709 , A61F9/008 , A61F2009/00863 , A61F2009/00872 , A61K31/121 , A61K31/167 , A61K31/192 , A61K31/336 , A61K31/52 , A61K31/7004
摘要： The invention generally provides methods for recruiting stem cells to an ocular tissue. The methods involve inducing heat shock in the ocular tissue using a subthreshold laser and/or an agent. In some embodiments, the heat shock is induced following the administration of an agent that mobilizes HSCs.
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