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    4-(3-BENZYLOXYPHENYLTHIO)-2-CHLORO-1-(3-NITROPROPYL)BENZENE CRYSTAL
    92.
    发明公开
    4-(3-BENZYLOXYPHENYLTHIO)-2-CHLORO-1-(3-NITROPROPYL)BENZENE CRYSTAL 有权
    4-（3-苄氧基苯硫基）-2- CHLOR-1-（3-硝基丙基）BENZOLKRISTALL

    公开(公告)号：EP2840079A1

    公开(公告)日：2015-02-25

    申请号：EP13778567.1

    申请日：2013-04-17

    申请人： Kyorin Pharmaceutical Co., Ltd.

    发明人： TSUBUKI, Takeshi ,  SATO, Hiroya

    IPC分类号： C07C323/20 ,  C07C319/28

    CPC分类号： C07C323/20 ,  C07B2200/13 ,  C07C319/28

    摘要： 4-(3-benzyloxyphenylthio)-2-chloro-1-(3-nitropropyl)benzene (compound 1) is used as an intermediate for producing a 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl]-1-,3-propanediol hydrochloride which has excellent immunosuppressive activity. This compound 1 is traditionally obtained only as an oil and thus handling and refining were difficult.
    [Solution] A crystal of the compound 1 is obtained. A method of crystallizing the same is also established. Furthermore, a simple refining method is also found which comprises stirring in suspension the crystal in a solvent. Since the compound 1 can be obtained as a crystal, it is easier to handle and long term storage is possible.

    摘要翻译： 使用4-（3-苄氧基苯硫基）-2-氯-1-（3-硝基丙基）苯（化合物1）作为制备2-氨基-2- [2- [4-（3-苄氧基苯硫基） - 2-氯苯基]乙基] -1-丙-1,3-二醇盐酸盐，具有优异的免疫抑制活性。 该化合物1传统上仅作为油获得，因此难以处理和精制。 [溶液]获得化合物1的晶体。 也建立了使其结晶的方法。 此外，还发现了一种简单的精炼方法，其包括将晶体悬浮在溶剂中进行搅拌。 由于化合物1可以作为晶体获得，因此易于处理并且可以长期储存。

    COMPLEX OF ORGANIC COMPOUND AND COPPER NANOPARTICLES, COMPLEX OF ORGANIC COMPOUND AND COPPER OXIDE (I) NANOPARTICLES, AND PROCESSES FOR PRODUCTION OF THE COMPLEXES
    94.
    发明公开
    COMPLEX OF ORGANIC COMPOUND AND COPPER NANOPARTICLES, COMPLEX OF ORGANIC COMPOUND AND COPPER OXIDE (I) NANOPARTICLES, AND PROCESSES FOR PRODUCTION OF THE COMPLEXES 有权
    从复杂有机化合物和铜纳米颗粒，有机化合物和氧化亚铜纳米粒子和方法的复杂用于生产复杂

    公开(公告)号：EP2551039A1

    公开(公告)日：2013-01-30

    申请号：EP11759147.9

    申请日：2011-02-28

    申请人： DIC Corporation

    发明人： SANO Yoshiyuki ,  JIN Ren-Hua ,  UOTA Masafumi

    IPC分类号： B22F1/02 ,  B22F1/00 ,  B22F9/24 ,  C01G3/02 ,  C07C323/12 ,  C07C323/19 ,  C07C323/20 ,  C07C323/52

    CPC分类号： C07F1/08 ,  B22F1/0018 ,  B22F1/02 ,  B22F9/24 ,  B82Y30/00 ,  B82Y40/00 ,  C01G3/02 ,  C01P2002/72 ,  C01P2004/64 ,  C07C323/12 ,  C07C323/20 ,  C07C323/52 ,  Y10S977/773 ,  Y10S977/896

    摘要： Provided is a composite including copper nanoparticles or copper(I) oxide nanoparticles and a thioether-containing organic compound represented by X(OCH 2 CHR 1 ) n OCH 2 CH(OH)CH 2 SZ [X represents an alkyl group; R 1 represents a hydrogen atom or a methyl group; n represents an integer of 2 to 100; R 1 is independent between repeating units and may be the same or different; and Z represents an alkyl group, an allyl group, an aryl group, an arylalkyl group, -R 2 -OH, -R 2 -NHR 3 , or -R 2 -(COR 4 ) m (where R 2 represents a saturated hydrocarbon group; R 3 represents a hydrogen atom, an acyl group, an alkoxycarbonyl group, or a benzyloxycarbonyl group; R 4 represents a hydroxy group, an alkyl group, or an alkoxy group; and m represents 1 to 3)]. Provided is a method for producing a composite of an organic compound and copper nanoparticles or a composite of an organic compound and copper(I) oxide nanoparticles, the method including reducing a copper compound in the presence of a thioether-containing organic compound represented by the general formula (1) above.

    摘要翻译： 本发明提供一种复合材料包含铜纳米颗粒或铜（I）氧化物纳米颗粒，并通过X（OCH 2 CHR 1）N OCH 2 CH（OH）CH 2 SZ [X darstellt到烷基的含硫醚的有机化合物; R 1表示氢原子或甲基; Ñdarstellt为2至100的整数; R 1为重复单元之间独立并且可以相同或不同; 和烷基的Ždarstellt到烯丙基，在芳基烷基的芳基，-R 2 -OH，-R 2 -NHR 3，或-R 2 - （COR 4）M（其中R 2表示的饱和烃 基团; R 3 darstellt氢原子，上酰基，烷氧基羰基，或者苄氧羰基; R 4表示羟基，烷基上的基团，或在烷氧基;并且m darstellt 1至3）。 提供了一种用于生产有机化合物和铜纳米颗粒的复合物，或有机化合物和铜（I）氧化物纳米颗粒的复合物，该方法包括在含硫醚的有机化合物的由所表示的存在下，还原铜化合物的方法 通式（1）的上方。

    PROCESS FOR PRODUCTION OF ALCOHOL COMPOUND
    95.
    发明授权
    PROCESS FOR PRODUCTION OF ALCOHOL COMPOUND 有权
    方法用于生产酒精相关

    公开(公告)号：EP2036878B1

    公开(公告)日：2012-08-22

    申请号：EP07768063.5

    申请日：2007-07-03

    申请人： Sumitomo Chemical Company, Limited

    发明人： SAKAMOTO, Toru ,  SEKO, Shinzo

    IPC分类号： C07C41/16 ,  C07C43/23 ,  C07C319/20 ,  C07C323/20 ,  C07B61/00

    CPC分类号： C07C41/16 ,  C07C319/20 ,  C07C323/20 ,  C07C43/23

    摘要： A process for the production of an alcohol compound represented by the formula (III), comprising reacting a phenol represented by the formula (I) with a haloalcohol represented by the formula (II) in a biphase system composed of a water-immiscible organic solvent and an aqueous alkali metal hydroxide solution in the presence of a phase-transfer catalyst. (I) wherein X1, X2, X3 and X4 independently represent a hydrogen atom, a halogen atom or an alkyl group having 1 to 3 carbon atoms; Z represents an oxygen atom or a sulfur atom; and R represents an alkyl group, an alkenyl group, an alkynyl group, or an aralkyl group which may be substituted by a halogen atom. (II) wherein Y represents a chlorine atom or a bromine atom; and n represents an integer of 2 or 3. (III) wherein X1, X2, X3, X4, Z, R and n are as defined above.

    DERIVES SOUFRES DE RESORCINOL, LEUR PREPARATION ET LEURS UTILISATIONS COSMETIQUES
    96.
    发明公开
    DERIVES SOUFRES DE RESORCINOL, LEUR PREPARATION ET LEURS UTILISATIONS COSMETIQUES 审中-公开
    GESCHWEFELTE DORIVATE VON RESORCIN，DEREN HERSTELLUNG UND DEREN KOSMETISCHE ANWENDUNGEN

    公开(公告)号：EP2417104A1

    公开(公告)日：2012-02-15

    申请号：EP10713194.8

    申请日：2010-04-08

    申请人： Pierre Fabre Dermo-Cosmétique

    发明人： POIGNY, Stéphane

    IPC分类号： C07C317/22 ,  C07C323/20 ,  A61K8/46 ,  A61Q5/08 ,  A61Q19/02 ,  A61Q19/08 ,  A61P17/00 ,  A01N31/16 ,  A01N39/00 ,  A01N41/10 ,  A01P1/00

    CPC分类号： C07C323/20 ,  A01N31/16 ,  A01N37/10 ,  A01N41/10 ,  A01N47/10 ,  A61K8/46 ,  A61K2800/522 ,  A61K2800/524 ,  A61Q5/08 ,  A61Q19/02 ,  A61Q19/08 ,  C07C317/22

    摘要： The present invention relates to a compound of the general formula (I) where: X = S, SO or SO
    2 ; and one of the radicals R
    1 and R
    2 is a hydrogen atom and the other is a radical: a C
    1 to C
    18 linear or branched alkyl, optionally substituted by one or more halogen atom(s); a C
    2 to C
    18 linear or branched alkenyl, optionally substituted by one or more halogen atom(s); an aralkyl, optionally substituted by one or more C
    1 to C
    6 alkoxy group(s); or a COR
    3 or CONHR
    3 , but not simultaneously, where R
    3 is a radical: a C
    1 to C
    18 linear or branched alkyl, optionally substituted by one or more halogen atom(s); a C
    2 to C
    18 linear or branched alkenyl, optionally substituted by one or more halogen atom(s); an aralkyl, optionally substituted by one or more C
    1 to C
    6 alkoxy group(s); an aralkenyl, optionally substituted by one or more C
    1 to C
    6 alkoxy groups and/or one or more OH group(s); or an aryl radical, optionally substituted by one or more C
    1 to C
    6 alkoxy group(s).

    摘要翻译： 本发明涉及通式（I）的化合物，其中：X = S，SO或SO 2; 基团R 1和R 2中的一个为氢原子，另一个为自由基：任选被一个或多个卤素原子取代的C 1至C 18直链或支链烷基; 任选被一个或多个卤素原子取代的C 2至C 18直链或支链烯基; 任选被一个或多个C 1至C 6烷氧基取代的芳烷基; 或COR 3或CONHR 3，但不是同时地，其中R 3是自由基：任选被一个或多个卤素原子取代的C 1 -C 18直链或支链烷基; 任选被一个或多个卤素原子取代的C 2至C 18直链或支链烯基; 任选被一个或多个C 1至C 6烷氧基取代的芳烷基; 任选被一个或多个C 1至C 6烷氧基和/或一个或多个OH基团取代的芳烯基; 或任选被一个或多个C 1至C 6烷氧基取代的芳基。