公开(公告)号：EP1805312B1

公开(公告)日：2009-07-15

申请号：EP05790011.0

申请日：2005-09-22

申请人： Bayer CropScience AG

发明人： FROHBERG, Claus ,  KOCH, Rainhard

IPC分类号： C12N15/82 ,  C12N9/10 ,  A01H5/00

CPC分类号： C08B37/0072 ,  A23L7/198 ,  A61K36/899 ,  C12N9/1051 ,  C12N15/8246

摘要： The present invention relates to plant cells and plants which synthesize hyaluronan and to methods for preparing such plants, and also to methods for preparing hyaluronan with the aid of these plant cells or plants. Furthermore, the present invention relates to the use of plants for preparing hyaluronan and to food or feed which comprises hyaluronan.

摘要翻译： 本发明涉及合成透明质酸的植物细胞和植物以及制备这种植物的方法，还涉及借助于这些植物细胞或植物制备透明质酸的方法。 此外，本发明涉及植物用于制备透明质酸的用途以及包含透明质酸的食物或饲料。

公开(公告)号：EP2039777A1

公开(公告)日：2009-03-25

申请号：EP07744851.2

申请日：2007-06-07

申请人： Kyowa Hakko Bio Co., Ltd.

发明人： MURATA, Hideki c/o Yamaguchi Production Center ,  FUKUDA, Kazuo c/o Logistics Center Kyowa Hakko Bio Co., Ltd.

IPC分类号： C12P19/26

CPC分类号： A61K31/728 ,  C08B37/0003 ,  C08B37/0072

摘要： A partially purified product of a hyaluronic acid salt obtained from a culture of a microorganism capable of producing hyaluronic acid, preferably a microorganism belonging to the genus Streptcoccus, is brought into contact with a solution containing a salt and a hydrophilic organic solvent, thereby transferring to a liquid phase, impurities contained in said partially purified product such as proteins, nucleic acids, colorants, endotoxins and the like, and then isolating the hyaluronic acid salt as a precipitate.

摘要翻译： 从能够产生透明质酸的微生物的培养物获得的部分纯化的透明质酸产物，优选属于Streptcoccus属的微生物与含有盐和亲水性有机溶剂的溶液接触，从而转移到 液相，所述部分纯化产物中含有的杂质如蛋白质，核酸，着色剂，内毒素等，然后分离出透明质酸盐作为沉淀物。

公开(公告)号：EP2038309A2

公开(公告)日：2009-03-25

申请号：EP07812817.0

申请日：2007-07-11

申请人： University of Utah Research Foundation

发明人： PRESTWICH, Glenn, D. ,  SERBAN, Monica

IPC分类号： C08B37/08

CPC分类号： C08B37/0072 ,  A61K9/06 ,  A61K47/36 ,  A61L27/38 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/402 ,  A61L2300/41 ,  A61L2300/414 ,  A61L2300/416 ,  C08B37/0063 ,  C08H1/00 ,  C08L5/08 ,  C12N5/0068 ,  C12N2533/80

摘要： Described herein are macromolecules modified with electrophilic groups and methods of making and using thereof. The preparation of a thiol-reactive, electrophililic derivative of HA in order to prepare 'crosslinker-free' hydrogels are described as well as compounds and methods that are capable of coupling two or more molecules, such as macromolecules, under mild conditions. Specifically disclosed is the introduction of reactive bromo- and iodoacetate functionalities at the hydroxyl groups that are abundantly present on the HA polymer. The 'crosslinker- free' hydrogels described have numerous applications including, but not limited to, drug delivery, small molecule delivery, wound healing, burn injury healing, tissue regeneration/engineering, cell culturing, and bio-artificial materials.

公开(公告)号：EP2011816A1

公开(公告)日：2009-01-07

申请号：EP08356103.5

申请日：2008-07-04

申请人： Piron, Estelle

发明人： Piron, Estelle

IPC分类号： C08J3/075 ,  C08J3/24 ,  C08L5/08 ,  A61L27/52 ,  A61L27/50 ,  A61L27/48 ,  C08B37/08

CPC分类号： A61L27/52 ,  A61L27/20 ,  A61L27/48 ,  A61L27/50 ,  C08B37/0072 ,  C08J3/075 ,  C08J3/246 ,  C08J2305/00 ,  C08J2305/08 ,  C08L5/08 ,  C08L2205/22 ,  C08L2666/26

摘要： La présente invention concerne des gels injectables de polysaccharides, comprenant au moins un premier gel de polysaccharide fortement réticulé sous forme de particules, et au moins un second gel de polysaccharide faiblement réticulé formant matrice, ledit au moins premier gel étant lié par liaisons de covalence audit au moins second gel.
Procédé de préparation desdits gels injectables, et utilisations notamment en chirurgie réparatrice, en chirurgie esthétique, et en chirurgie de comblement des tissus biologiques.

摘要翻译： 共交联的凝聚凝胶包括以均匀分布在第二弱交联多糖凝胶中的颗粒形式强烈交联的多糖的第一凝胶，其中第一凝胶与第二凝胶共价结合，并且强烈交联的速率 交联多糖比弱交联多糖的交联率高。 包括独立权利要求：（1）包含凝胶的组合物; （2）凝胶制剂，包括提供第一强交联多糖颗粒，将提供步骤中获得的颗粒在水性介质中混合以获得悬浮液，向悬浮液中加入第二多糖，其中第二多糖相同或 与第一多糖不同，交联第二多糖直到交联速率X2以获得第二多糖的第二弱共交联多糖，在交联剂的存在下与颗粒弱交联，从而获得 共交联凝胶和回收共交联凝胶，其包含与第二弱交联多糖的基质共价结合的第一强交联多糖的颗粒; （3）用于注射包含共交联凝胶的凝胶的试剂盒，优选以准备使用的水凝胶的形式，在无菌注射器中调理并需要注射，包括注射针。

公开(公告)号：EP2007816A1

公开(公告)日：2008-12-31

申请号：EP07731267.6

申请日：2007-04-06

申请人： Adocia

发明人： SOULA, Gérard ,  SOULA, Rémi ,  SOULA, Olivier

IPC分类号： C08B37/00 ,  C08B15/06 ,  C08B37/02 ,  C08B37/04 ,  C08B37/08 ,  C08B37/14 ,  A61K47/36

CPC分类号： A61K9/0019 ,  A61K47/36 ,  C08B11/20 ,  C08B15/06 ,  C08B37/00 ,  C08B37/0021 ,  C08B37/003 ,  C08B37/0045 ,  C08B37/0069 ,  C08B37/0072 ,  C08B37/0084

摘要： The invention concerns a dextran and/or dextran derivative bifunctionalized by at least one imidazolyl radical (Im) and at least one hydrophobic group (Hy), said radical and group being each, identical and/or different, and, grafted or bound to the dextran and/or dextran derivative by one or more linker arms R, Ri or Rh and functions F, Fi or Fh as well as pharmaceutical compositions comprising one of said dextrans and at least one active principle.

公开(公告)号：EP1994062A1

公开(公告)日：2008-11-26

申请号：EP07702514.6

申请日：2007-03-02

申请人： Novozymes Biopolymer A/S

发明人： EENSCHOOTEN, Corinne ,  CHRISTENSEN, Morten, Würtz

IPC分类号： C08B37/08 ,  A61K31/728 ,  A61K8/73 ,  A61K47/36

CPC分类号： A61K8/735 ,  A61K31/728 ,  A61K47/36 ,  A61K2800/52 ,  A61Q7/00 ,  A61Q19/00 ,  A61Q19/08 ,  C08B37/0072 ,  C08L5/08

摘要： A hyaluronic acid derivative, and methods of producing and using said derivative, the derivative comprising n repeating units and having the general structural formula (I), wherein, in at least one repeating unit, one or more of R1, R2, R3, R4 comprises an etherbound aryl/alkyl sulfone having the general structural fomula (II), wherein R comprises an alkyl- or aryl-group, and otherwise R1, R2, R3, R4 are hydroxyl groups, OH.

公开(公告)号：EP1948131A2

公开(公告)日：2008-07-30

申请号：EP06818627.9

申请日：2006-11-17

申请人： URSAPHARM Arzneimittel GmbH & Co. KG

发明人： HOLZER, Frank ,  GROSS, Dorothea

IPC分类号： A61K9/00

CPC分类号： A61K31/728 ,  A61K9/0048 ,  A61K31/00 ,  A61K47/36 ,  C08B37/0072

摘要： The invention relates to a pharmaceutical composition that is free from dexpanthenol, calcium ions, and phosphate and comprises at least one calcium chelating agent, at least one ophthalmologically compatible viscosity regulator, and one or several optional pharmaceutical adjuvants. The invention further relates to the use of a calcium chelating agent and an ophthalmologically compatible viscosity regulator for producing a phosphate-free pharmaceutical composition used for the treatment and/or prevention of epithelial defects.

公开(公告)号：EP1174463A4

公开(公告)日：2008-04-16

申请号：EP00904045

申请日：2000-02-18

申请人： DENKI KAGAKU KOGYO KK

发明人： HASHIMOTO MASAMICHI ,  UMEDA TOSHIHIKO ,  ARAI KAZUHIKO ,  MIYATA YOSHIAKI ,  YAMAMOTO OSAMU ,  HIMEDA YASUKAZU

IPC分类号： A61L26/00 ,  A61L27/20 ,  A61L27/52 ,  A61L31/04 ,  C08B37/08 ,  C08L1/28 ,  C08L5/08 ,  C08L29/04 ,  A61L15/64 ,  C08L1/26

CPC分类号： A61L31/042 ,  A61L26/0023 ,  A61L26/008 ,  A61L27/20 ,  A61L27/52 ,  C08B37/0072 ,  C08L1/286 ,  C08L5/08 ,  C08L29/04 ,  C08L1/26 ,  C08L2666/02

摘要： A hyaluronic acid gel composition comprising hyaluronic acid and a polymer, which is substantially unmodified with a chemical cross-linking agent or a chemical modifying agent and which has a percentage dissolution of hyaluronic acid of 50% or lower in 12 hours in a neutral aqueous solution of 37 DEG C.

公开(公告)号：EP1896511A1

公开(公告)日：2008-03-12

申请号：EP06769044.6

申请日：2006-06-26

申请人： Bioland Ltd.

发明人： KIM, Ki Soo ,  KIM, Jin Guk ,  CHOI, Bong Rak ,  KIM, Young Heui ,  KIM, Ki Ho ,  YU, Heui Jong ,  CHO, Nam Suk

IPC分类号： C08B37/08

CPC分类号： C08B37/0072 ,  A23L33/10

摘要： Present invention relates to a method for preparing low molecular weight hyaluronic acid and the salt thereof from high molecular weight hyaluronic acid using by ion exchange resin and it has various advantages over prior arts such as easy to mass production, economic production, uniform production of purposed low molecular weight hyaluronic acid, prevention of the ring cleavage of monosacchride in hyaluronic acid occurring in chemical hydrolysis and undesired formation of by-product having double bonded sugar ring occurring in enzymatic hydrolysis. Therefore, the inventive method of the present invention could provide effective and economic method for preparing low-molecular weight hyaluronic acid with mass production and low cost and the low molecular weight hyaluronic acid and the salt thereof prepared from the method of the present invention may extensively be used as a medicine, cosmetic, medical material, food additives etc.

公开(公告)号：EP1879924A2

公开(公告)日：2008-01-23

申请号：EP06722923.7

申请日：2006-04-28

申请人： Novozymes Biopolymer A/S

发明人： THWAITES, Eric ,  BARFOD, Martin ,  BACH, Poul

IPC分类号： C08B37/00 ,  C08B37/10

CPC分类号： C08B37/0003 ,  C08B37/0072

摘要： The invention provides in a first aspect a method for controlling the content of selected component(s) in one or more polymer(s) by: (a) contacting the polymer(s) with at least one molecular sieve; and optionally (b) isolating the polymer from the molecular sieve(s).