公开(公告)号：EP1736060A2

公开(公告)日：2006-12-27

申请号：EP06020381.7

申请日：2003-04-08

申请人： Ocean Nutrition Canada Ltd.

发明人： Yan, Nianxi

IPC分类号： A23L1/00 ,  A23L1/30 ,  A61K9/50 ,  B01J13/10

CPC分类号： A23L1/0029 ,  A23L33/115 ,  A23P10/30 ,  A23V2002/00 ,  A61K9/501 ,  A61K9/5052 ,  B01J13/10 ,  Y10S514/962 ,  Y10S514/963 ,  Y10T428/2984 ,  Y10T428/2985 ,  Y10T428/2989 ,  Y10T428/2991 ,  A23V2200/224 ,  A23V2250/5432 ,  A23V2250/1618

摘要： Microcapsules comprising an agglomeration of primary microcapsules, each individual primary microcapsule having a primary shell and the agglomeration being encapsulated by an outer shell, may be prepared by providing an aqueous mixture of a loading substance and a shell material, adjusting pH, temperature, concentration and/or mixing speed to form primary shells of shell material around the loading substance and cooling the aqueous mixture until the primary shells agglomerate and an outer shell of shell material forms around the agglomeration. Such microcapsules are useful for storing a substance and for delivering the substance to a desired environment.

摘要翻译： 包括初级微胶囊聚集的微胶囊，每个单独的初级微胶囊具有主要外壳，并且由外壳包封的附聚物可以通过提供负载物质和壳材料的水性混合物来调节pH，温度，浓度和 /或混合速度以在负载物质周围形成壳材料的初级壳体并冷却含水混合物，直到初级壳体附聚物和外壳材料的外壳围绕附聚物形成。 这种微胶囊可用于储存物质并将物质输送到期望的环境中。

公开(公告)号：EP1718406A1

公开(公告)日：2006-11-08

申请号：EP05717631.5

申请日：2005-02-14

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE

发明人： DUBOIS, Monique ,  ZEMB, Thomas

IPC分类号： B01J13/10

CPC分类号： B01J13/10 ,  A61K9/1274

摘要： The invention relates to crystallised, catanionic membranes in organised solid bilayer form, comprising laterally-alternating anionic surfactants (TA) with H+ counter ions and cationic surfactants (TC) with OH- counter ions which are co-crystallised with a mole fraction QTA/(QTA + QTC) greater than 0.5. According to the invention, the membrane forms a surface which is flat, at least locally, and the bilayer is stabilised by at least one polymer which is neutral and hydrophobic or which has an opposite overall electric charge to the effective charge of the catanionic membrane, said polymer being absorbed on the surface. The invention also relates to a method of preparing the membranes, the uses thereof, for example, as a medicament for the vectorisation of active species or for the retention of volatile molecules.

公开(公告)号：EP1585592A1

公开(公告)日：2005-10-19

申请号：EP03813094.4

申请日：2003-11-11

申请人： UNILEVER N.V. ,  UNILEVER PLC

发明人： MELLEMA, Michel,Unilever R & D Vlaardingen

IPC分类号： B01J13/10 ,  B01J13/14 ,  A23L1/30 ,  A23P1/04 ,  A61K9/50

CPC分类号： A23D7/0056 ,  A23D7/015 ,  A23L5/44 ,  A23L33/105 ,  A23L33/155 ,  A23P10/30 ,  A23V2002/00 ,  A61K9/5036 ,  A61K9/5052 ,  B01J13/10 ,  A23V2200/224 ,  A23V2250/54244 ,  A23V2250/5072 ,  A23V2250/54246 ,  A23V2250/5036 ,  A23V2250/5028 ,  A23V2250/5026 ,  A23V2250/211

摘要： The invention relates to a complex coacervate encapsulate comprising a lipophilic core and a hydrophilic wall, wherein the wall substantially covers the core, wherein the wall substantially consists of beta-lactoglobulin and one or more polymers having an isoelectric point below that of beta-lactoglobulin.

摘要翻译： 本发明涉及包含亲脂性核和亲水性壁的复合凝聚层胶囊，其中所述壁基本上覆盖所述核，其中所述壁基本上由β-乳球蛋白和一种或多种等电点低于β-乳球蛋白的聚合物组成。

公开(公告)号：EP1524030A1

公开(公告)日：2005-04-20

申请号：EP03023471.0

申请日：2003-10-18

申请人： Cognis Iberia S.L

发明人： Viladot Petit, Josep-Lluis, Dr. ,  Asensio, Juan-Antonio ,  Seva, Manuel

IPC分类号： B01J13/04 ,  B01J13/10 ,  B05B1/02 ,  B05B7/04

CPC分类号： B05B1/02 ,  B01J13/04 ,  B01J13/10 ,  B05B7/0416

摘要： Vorgeschlagen wird ein Verfahren zur kontinuierlichen Herstellung von Mikrokapseln mit einem mittleren Durchmesser von 0,1 bis 5 mm durch Vertropfen und spontane Koazervation einer gegebenenfalls mit Wirk- und Zusatzstoffen beladenen Zubereitung einer ersten Komponente (a) in die Zubereitung einer zweiten Komponente (b), welches sich dadurch auszeichnet, dass die Vertropfung durch mindestens eine Kapillare erfolgt und der Abriss der Tropfen am Auslass der Kapillare durch mindestens einen horizontal, tangential oder vertikal zur Fallrichtung der Tropfen verlaufenden Gasstrom bewirkt wird.

摘要翻译： 通过液滴形成和可能含有活性和添加物质的制剂的自发凝聚来生产平均直径为0.1mm至5mm的微胶囊的方法包括使用至少一个毛细管和至少一个气流在管中进行液滴分离 结束。 还包括用于实现所提出的方法的装置的独立权利要求。

公开(公告)号：EP0856355B1

公开(公告)日：2004-04-07

申请号：EP98101258.6

申请日：1998-01-26

申请人： Givaudan SA

发明人： Soper, Jon C. ,  Thomas, M. Teresa

IPC分类号： B01J13/02 ,  B01J13/10

CPC分类号： B01J13/02 ,  Y10T428/2984 ,  Y10T428/2985

公开(公告)号：EP1371410A1

公开(公告)日：2003-12-17

申请号：EP02077443.6

申请日：2002-06-14

申请人： NIZO food research

发明人： The designation of the inventor has not yet been filed

IPC分类号： B01J13/10

CPC分类号： B01J13/10

摘要： A new and improved method of micro-encapsulation by complex coacervation is provided which comprises the use of whey proteins together with a weak polyelectrolyte substituting for gelatin to allow better use of the encapsulated material, preferably in conjunction with gum Arabic.

摘要翻译： 提供了一种新的改进的复合凝聚微胶囊化方法，其包括将乳清蛋白与弱聚合电解质一起用于明胶，以更好地使用包封的材料，优选与阿拉伯胶。

公开(公告)号：EP1307282A1

公开(公告)日：2003-05-07

申请号：EP01971841.0

申请日：2001-08-01

申请人： Max-Planck-Gesellschaft zur Förderungder Wissenschaften e.V.

发明人： VOIGT, Andreas ,  SUKHORUKOV, Gleb ,  ANTIPOV, Alexei ,  DONATH, Edwin ,  MÖHWALD, Helmuth ,  SEIBT, Horst

IPC分类号： B01J13/02 ,  B01J13/10 ,  B01J13/22

CPC分类号： A61K9/5192 ,  A61K9/5026 ,  A61K9/5089 ,  A61K9/5138 ,  B01J13/02 ,  B01J13/10 ,  B01J13/22 ,  Y10T428/2984

摘要： The invention relates to a method for applying a shell to liquid template particles, comprising the following steps: (a) preparation of an emulsion of liquid template particles in a continuous liquid or gel phase, whereby at least one amphiphilic polyelectrolyte or polyelectrolyte complex, or a copolymer of charged hydrophilic monomers and oil soluble monomers is dissolved in the fluid template particles and/or the continuous phase and a film is formed at the phase boundary between the liquid template particle and the continuous phase and (b) application of a shell to the film formed at the phase boundary.

公开(公告)号：EP1246692A1

公开(公告)日：2002-10-09

申请号：EP01903643.3

申请日：2001-01-12

申请人： Max-Planck-Gesellschaft zur Förderungder Wissenschaften e.V.

发明人： CARUSO, Frank ,  TRAU, Dieter,The Hong Kong University ,  MÖHWALD, Helmuth ,  RENNEBERG, Reinhard,The Hong Kong University

IPC分类号： B01J13/10 ,  B01J13/22 ,  A61K7/00 ,  A23P1/04 ,  A61K9/50

CPC分类号： A61K8/11 ,  A23P10/30 ,  A61K9/5089 ,  A61K2800/412 ,  A61K2800/434 ,  A61Q19/00 ,  B01J13/10 ,  B01J13/22

摘要： The invention is directed to (i) the encapsulation of uncharged organic substances in polymeric capsules by using a multi-step strategy that involves charging the surface of the microcrystals with an amphiphilic substance, followed by consecutively depositing polyelectrolytes of opposite charge to assemble a multilayered shell of polymeric material around the microcrystal template, and (ii) the formation of polymer multilayer cages derived from the coated crystals by facile removal of the crystalline template.

公开(公告)号：EP1116516A1

公开(公告)日：2001-07-18

申请号：EP00111523.7

申请日：2000-05-29

申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

发明人： Caruso, Dr. Frank ,  Möhwald, Prof. Dr.Helmuth ,  Trau, Dieter ,  Renneberg, Prof. Dr.Reinhard

IPC分类号： B01J13/10 ,  B01J13/22 ,  A61K7/00 ,  A23P1/04 ,  A61K9/50

CPC分类号： A61K8/11 ,  A23P10/30 ,  A61K9/5089 ,  A61K2800/412 ,  A61K2800/434 ,  A61Q19/00 ,  B01J13/10 ,  B01J13/22

摘要： The invention is directed to (i) the encapsulation of electrically uncharged organic substances in polymeric capsules by using a multi-step strategy that involves charging the surface of the microcrystals with an amphiphilic substance, followed by consecutively depositing polyelectrolytes of opposite charge to assemble a multilayered shell of polymeric material around the microcrystal template, and (ii) the formation of polymer multilayer cages derived from the coated crystals by facile removal of the crystalline template.

摘要翻译： 本发明涉及（i）通过使用多步骤策略将电不带电荷的有机物质包封在聚合物胶囊中，所述多步骤策略涉及用两亲物质对微晶体的表面进行充电，随后连续沉积相反电荷的聚电解质以组装多层 在微晶模板周围的聚合材料壳，和（ii）通过容易地除去结晶模板形成由涂覆的晶体衍生的聚合物多层笼。

公开(公告)号：EP0771190A4

公开(公告)日：2000-12-20

申请号：EP95926758

申请日：1995-07-19

申请人： UNIV SOUTH FLORIDA

发明人： NEWKOME GEORGE R ,  MOOREFIELD CHARLES N ,  BAKER GREGORY R

IPC分类号： A61K9/107 ,  A61K47/30 ,  A61K47/48 ,  B01F17/30 ,  C07C233/47 ,  C07D213/68 ,  C07D213/75 ,  C07D239/62 ,  C07D239/64 ,  C08G73/02 ,  C08G73/06 ,  C08J3/02 ,  A61K9/50 ,  A61K51/00 ,  B01J13/00 ,  B01J13/10

CPC分类号： C07D213/75 ,  A61K47/6907 ,  A61K47/6949 ,  B82Y5/00 ,  C07C233/47 ,  C07D213/68 ,  C07D239/62 ,  C07D239/64 ,  C08G73/028 ,  C08G73/0627 ,  Y10S424/16 ,  Y10S525/903 ,  Y10S525/936 ,  Y10T428/2985 ,  Y10T428/2987

摘要： A lock unimolecular micelle includes at least one engineered acceptor specifically binding a ligand (or specifically a 'key' unimolecular micelle) thereto. A key unimolecular micelle comprises a core molecule and a plurality of branches extending therefrom, at least one of the branches including a shank portion extending therefrom having a terminal moiety at an end thereof for binding to a complimentary acceptor of a lock unimolecular micelle. Together, the lock and key micelles form a unit, either irreversibly or reversibly bound wherein the lock micelles is a soluble receptor engineered to specifically bind to the specifically engineered key micelle.

摘要翻译： 锁定单分子胶束包括至少一个特异性结合配体（或特别是“关键”单分子胶束）的工程受体。 关键的单分子胶束包含核心分子和从其延伸的多个分支，至少一个分支包括从其延伸的柄部分，其末端具有末端部分以结合锁定单分子胶束的互补受体。 锁和键胶束一起形成单元，或者不可逆地或可逆地结合，其中锁胶团是可溶性受体，其被设计为特异性地结合到特定设计的关键胶粒。