公开(公告)号：EP3275969A1

公开(公告)日：2018-01-31

申请号：EP16768508.0

申请日：2016-03-14

申请人： Hodogaya Chemical Co., Ltd. ,  Hirata Corporation ,  Kyushu University National University Corporation

发明人： ADACHI, Chihaya ,  NISHIDE, Jun-ichi ,  HIRAGA, Yasuhide ,  TAKAHASHI, Takehiro

IPC分类号： C09K11/06 ,  C07D209/86 ,  H01L51/50

CPC分类号： H01L51/5056 ,  C07D209/86 ,  C09K11/06 ,  H01L51/50 ,  H01L51/5072 ,  H01L51/5092

摘要： To provide a light-emitting material of a light emitting layer, particularly a dopant material or a host material of a light emitting layer emitting delayed fluorescence, or a material suitable for a hole blocking layer, as a material for an organic electroluminescent device having a high efficiency, and also to provide an organic photoluminescent device or an organic electroluminescent device having a high efficiency and a high luminance, particularly an organic EL device suppressed in the roll-off phenomenon, by using the material.
A material for an organic electroluminescent device, containing a benzonitrile derivative of the following general formula (1), and an organic electroluminescent device containing a pair of electrodes and one layer or plural layers including at least a light emitting layer intervening between the electrodes, the organic electroluminescent device using the material.

摘要翻译： 为了提供发光层的发光材料，尤其是发射延迟荧光的发光层的掺杂剂材料或主体材料，或者适合于空穴阻挡层的材料，作为用于有机电致发光器件的材料 并且通过使用该材料还提供具有高效率和高亮度的有机光致发光装置或有机电致发光装置，特别是抑制滚落现象的有机EL装置。 一种有机电致发光元件用材料，其特征在于，含有下述通式（1）所示的苯甲腈衍生物和有机电致发光元件，所述有机电致发光元件含有一对电极和至少包含介于所述电极间的发光层的一层或多层， 使用该材料的有机电致发光器件。

公开(公告)号：EP2511358B1

公开(公告)日：2018-01-03

申请号：EP10835820.1

申请日：2010-11-18

申请人： Kyushu University, National University Corporation ,  Mitsui Mining and Smelting Co., Ltd.

发明人： DOI, Toshiro ,  KUROKAWA, Syuhei ,  OHNISHI, Osamu ,  HASEGAWA, Tadashi ,  KAWASE, Yasuhiro ,  YAMAGUCHI, Yasuhide

IPC分类号： C09K3/14 ,  B24B37/04 ,  H01L21/304 ,  C09G1/02 ,  H01L21/02 ,  H01L29/16

CPC分类号： C09K3/1463 ,  B24B37/044 ,  C09G1/02 ,  H01L21/02024 ,  H01L29/1608

摘要： The present invention provides an abrasive treatment technique capable of planarizing at an extremely high rate silicon carbide, which is thermally and chemically extremely stable and for which it is extremely difficult to efficiently perform an abrasive treatment. The present invention is a polishing slurry for silicon carbide wherein the polishing slurry includes a suspension liquid in which the pH thereof is 6.5 or more and manganese dioxide particles are suspended. The polishing slurry for silicon carbide is preferably a suspension in which manganese dioxide particles are suspended in an aqueous solution allowed to have a redox potential falling in a range enabling manganese to be present as manganese dioxide. The redox potential V of the polishing slurry preferably falls within the range specified by the following formula representing a relation between V and pH, pH being a variable: 1.014 - 0.591 pH ‰¤ V ‰¤ 1.620 - 0.0743 pH

公开(公告)号：EP2960349B1

公开(公告)日：2017-10-04

申请号：EP14785986.2

申请日：2014-04-08

申请人： Kyushu University, National University Corporation ,  Sumitomo Metal Mining Co., Ltd.

发明人： GOTO, Masahiro ,  KUBOTA, Fukiko ,  BABA, Yuzo

IPC分类号： C22B11/00 ,  C22B3/26

CPC分类号： C22B61/00 ,  C07C237/06 ,  C22B11/04

公开(公告)号：EP3214666A1

公开(公告)日：2017-09-06

申请号：EP15855365.1

申请日：2015-10-30

申请人： Kyushu University National University Corporation

发明人： NAKANOTANI Hajime ,  ADACHI Chihaya ,  HIGUCHI Takahiro

IPC分类号： H01L51/50 ,  H05B33/12 ,  H05B33/22

CPC分类号： H01L51/5036 ,  C09K11/06 ,  H01L51/50 ,  H01L51/5024 ,  H01L51/5044 ,  H01L51/5056 ,  H05B33/14 ,  H05B33/22 ,  Y02B20/181

摘要： An organic light-emitting device having a layer 10 containing a delayed blue fluorescent material, a layer 11 containing separately or together a green fluorescent material and a red fluorescent material, and a spacer layer 12 arranged between the layer 10 and the layer 11 can efficiently emit white color.

摘要翻译： 具有包含延迟的蓝色荧光材料的层10，分开或一起包含绿色荧光材料和红色荧光材料的层11以及布置在层10和层11之间的间隔层12的有机发光装置可以有效地 发出白色。

公开(公告)号：EP3205639A1

公开(公告)日：2017-08-16

申请号：EP15848889.0

申请日：2015-09-30

申请人： Kyushu University, National University Corporation

发明人： TORIKAI, Kohei

IPC分类号： C07C43/174 ,  C07B51/00 ,  C07C41/16 ,  C07C43/164 ,  C07C309/63

CPC分类号： C07B41/02 ,  C07B51/00 ,  C07C15/14 ,  C07C22/04 ,  C07C41/16 ,  C07C43/164 ,  C07C43/174 ,  C07C309/63 ,  C07D209/04 ,  C07D215/02 ,  C07D333/72 ,  Y02P20/55

摘要： A novel agent for introducing a protecting group for a hydroxy group and/or a mercapto group that can be introduced and removed under mild conditions is provided. The agent for introducing a protecting group for a hydroxy group and/or mercapto group of a substrate compound having the hydroxy group and/or mercapto group is represented by the following formula (I), wherein A represents a ring structure having 1 to 5 rings in which two carbon atoms of an adjacent benzene ring are included, the ring structure comprises a substituted or unsubstituted five-membered ring or six-membered ring and optionally include a heterocycle; each of R 1 , R 2 , R 3 , and R 4 is independently a hydrogen atom or a linear or branched alkyl group having 1 to 5 carbon atoms; and X is a halogen atom or OSO 2 R 5 (R 5 = an aryl group or an alkyl group) .

摘要翻译： 提供了用于引入可在温和条件下引入和除去的羟基和/或巯基的保护基的新型试剂。 用于引入具有羟基和/或巯基的底物化合物的羟基和/或巯基的保护基团的试剂由下式（I）表示：其中A表示具有1至5个环的环结构 其中包括相邻苯环的两个碳原子，所述环结构包含取代或未取代的五元环或六元环并且任选地包含杂环; R 1，R 2，R 3和R 4中的每一个独立地为氢原子或具有1至5个碳原子的直链或支链烷基; X是卤原子或OSO 2 R 5（R 5 =芳基或烷基）。

公开(公告)号：EP3176241A1

公开(公告)日：2017-06-07

申请号：EP16189891.1

申请日：2010-12-02

申请人： Nippon Steel & Sumikin Chemical Co., Ltd. ,  Kyushu University, National University Corporation

发明人： ENDO, Ayataka ,  ADACHI, Chihaya ,  YOSHIMURA, Kazuaki ,  KAWADA, Atsushi ,  MIYAZAKI, Hiroshi ,  KAI, Takahiro

IPC分类号： C09K11/06 ,  C07D519/00 ,  H01L51/50 ,  C09B57/00 ,  H01L51/00 ,  H05B33/10 ,  C07D487/04 ,  C07D209/86

CPC分类号： C09K11/06 ,  C07D209/86 ,  C07D487/04 ,  C09B57/00 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1018 ,  C09K2211/1029 ,  C09K2211/1044 ,  C09K2211/1059 ,  H01L51/0072 ,  H01L51/5012 ,  H05B33/10 ,  Y10S428/917

摘要： Provided are a fluorescence-emitting material which improves luminous efficiency of an organic light-emitting element such as an organic EL element or an organic PL element and an organic light-emitting element using the fluorescence-emitting material. The fluorescence-emitting material includes a compound having an indolocarbazole skeleton represented by the following general formula (1). The organic light-emitting element includes an organic EL element including: a substrate; an anode; a cathode; and a light-emitting layer, the anode and the cathode being laminated on the substrate and the light-emitting layer being sandwiched between the anode and the cathode, in which the light-emitting layer includes: the organic light-emitting material; and as a host material, an organic compound having excited triplet energy higher than that of the organic light-emitting material. In the general formula (1) : a ring A represents an aromatic ring represented by the formula (1a) to be fused with an adjacent ring; a ring B represents a heterocycle represented by the formula (1b) to be fused with an adjacent ring; Ar represents an aromatic hydrocarbon group or an aromatic heterocyclic group; R's each represent hydrogen or a monovalent substituent; and n represents an integer of 1 to 4.

摘要翻译： 本发明提供一种提高有机EL元件或有机PL元件等有机发光元件或使用该荧光发光材料的有机发光元件的发光效率的荧光发光材料。 荧光发光材料包括具有由以下通式（1）表示的吲哚并咔唑骨架的化合物。 有机发光元件包括有机EL元件，该有机EL元件包括：基板; 阳极; 阴极; 以及发光层，所述阳极和所述阴极层叠在所述基板上，并且所述发光层夹在所述阳极和所述阴极之间，其中所述发光层包括：所述有机发光材料; 并且作为主体材料，具有比有机发光材料更高的激发三重态能量的有机化合物。 在通式（1）中：环A表示由式（1a）表示的与邻近的环稠合的芳族环; 环B表示由式（1b）表示的与相邻的环稠合的杂环; Ar表示芳香族烃基或芳香族杂环基， R各自表示氢或一价取代基; 并且n表示1至4的整数。

公开(公告)号：EP3118205A1

公开(公告)日：2017-01-18

申请号：EP15762299.4

申请日：2015-03-03

申请人： Kyushu University National University Corporation ,  Shin-Etsu Chemical Co., Ltd.

发明人： NAGASHIMA Hideo ,  SUNADA Yusuke ,  OGUSHI Hajime ,  SAKUTA Koji

IPC分类号： C07F19/00 ,  B01J31/22 ,  C07C5/03 ,  C07C9/15 ,  C07C15/073 ,  C07C209/50 ,  C07C211/04 ,  C07F7/08 ,  C07B61/00 ,  C07F15/00

摘要： A neutral or cationic mononuclear ruthenium divalent complex represented by formula (1) can actualize exceptional catalytic activity in at least one reaction among a hydrosilylation reaction, hydrogenation reaction, and carbonyl compound reduction reaction.

(In the formula, R 1 -R 6 each independently represent a hydrogen atom or an alkyl group, aryl group, aralkyl group, organooxy group, monoorganoamino group, diorganoamino group, monoorganophosphino group, diorganophosphino group, monoorganosilyl group, diorganosilyl group, triorganosilyl group, or organothio group optionally substituted by X; at least one pair comprising any of R 1 -R 3 and any of R 4 -R 6 together represents a crosslinkable substituent; X represents a halogen atom, organooxy group, monoorganoamino group, diorganoamino group, or organothio group; L each independently represent a two-electron ligand other than CO and thiourea ligands; two L may bond to each other; and m represents an integer of 3 or 4.)

摘要翻译： 由式（1）表示的中性或阳离子单核钌二价络合物可以在氢化硅烷化反应，氢化反应和羰基化合物还原反应中的至少一个反应中实现卓越的催化活性。 （式中，R 1 -R 6各自独立地表示氢原子或烷基，芳基，芳烷基，有机氧基，单官能氨基，二有机基氨基，单官能团，二有机膦基，单有机甲硅烷基，二有机甲硅烷基，三有机甲硅烷基 或任选被X取代的有机硫基;至少一对包含R 1 -R 3和R 4 -R 6中的任一个一起代表可交联取代基; X表示卤素原子，有机氧基，单有机基氨基，二有机基氨基， 或有机硫基; L各自独立地表示除CO和硫脲配体以外的双电子配体;两个L可以彼此键合; m表示3或4的整数。）

公开(公告)号：EP3081939A1

公开(公告)日：2016-10-19

申请号：EP14868998.7

申请日：2014-12-11

申请人： Shiseido Company Ltd. ,  Kyushu University, National University Corporation

发明人： HAMASE, Kenji ,  MIYOSHI, Yurika ,  MITA, Masashi

IPC分类号： G01N33/68 ,  G01N33/493

CPC分类号： G01N33/6812 ,  G01N2800/347

摘要： The present invention addresses the problem of identifying a biomarker of renal failure, said biomarker being available from urine or blood, and fluctuating from an early stage than glomerular filtration rate and serum creatinine level, and thus developing a technique for diagnosing early stage kidney failure. A method for analyzing the blood, plasma, serum or urine of a renal failure suspected subject comprises a step of measuring the concentration of a pair of D-form and L-form of at least one amino acid selected from the amino acid group consisting of [D-serine] and [L-serine], etc., contained in the blood, plasma, serum or urine of the subject, and calculating, as an pathological index of the subject, the ratio of the D-form concentration to the L-form concentration or the percentage of the D-form concentration relative to the total concentration of the D-form and L-form.

公开(公告)号：EP2130910B1

公开(公告)日：2016-10-19

申请号：EP08739932.5

申请日：2008-03-31

申请人： Kyushu University, National University Corporation

发明人： KOGA, Toshinobu ,  NAGASATO, Soichi ,  IWAMOTO, Yukihide ,  NAKAYAMA, Koichi

IPC分类号： A61L27/38 ,  C12N5/0775 ,  C12N5/07 ,  C12N11/00

CPC分类号： C12N5/0062 ,  A61L27/3843 ,  C12M23/08 ,  C12M25/00 ,  C12N11/00

公开(公告)号：EP3000876A1

公开(公告)日：2016-03-30

申请号：EP14801845.0

申请日：2014-05-14

申请人： Kyushu University National University Corporation ,  Tella, Inc.

发明人： YONEMITSU, Yoshikazu ,  SAITO, Satoru ,  HARADA, Yui ,  YAZAKI, Yuichiro ,  ISHIDAO, Takefumi

IPC分类号： C12N5/0783 ,  A61K35/14 ,  A61P31/04 ,  A61P31/12 ,  A61P35/02

CPC分类号： C12N5/0646 ,  A61K35/17 ,  A61K35/51 ,  A61K35/545 ,  C12N2500/90 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/22 ,  C12N2501/2302 ,  C12N2501/2306 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2501/26 ,  C12N2502/1171 ,  C12N2506/11

摘要： [Problem to be Solved]
To develop a technique in which NK cells having a high cytotoxic activity can be prepared with high purity from hematopoietic precursor cells without using a serum or feeder cells of an animal.
[Solution]
A method for expanding NK cells includes the steps of expanding hematopoietic precursor cells under a single culturing condition using a medium supplemented with IL-15, SCF, IL-7 and Flt3L, and differentially inducing the cells obtained in the expanding step into NK cells under a culturing condition using a medium supplemented with IL-2. A pharmaceutical composition contains the NK cells prepared by the method for expanding NK cells of the present invention. The pharmaceutical composition of the present invention is used for treating an infectious disease and/or a cancer.

摘要翻译： [待解决的问题]为了开发可以从造血前体细胞制备具有高细胞毒活性的NK细胞而不使用动物的血清或饲养细胞的技术。 [解决方案]扩增NK细胞的方法包括以下步骤：使用补充有IL-15，SCF，IL-7和Flt3L的培养基在单一培养条件下扩增造血前体细胞，并将扩增步骤中获得的细胞差异诱导 NK细胞在培养条件下使用补充有IL-2的培养基。 药物组合物含有通过本发明的NK细胞扩增方法制备的NK细胞。 本发明的药物组合物用于治疗感染性疾病和/或癌症。