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    Pharmaceutical agents for the treatment of cerebral amyloidosis
    5.
    发明公开
    Pharmaceutical agents for the treatment of cerebral amyloidosis 失效
    Pharmazutische Wirkstoffe zur Behandlung von Hirnamyloidose

    公开(公告)号：EP1930308A1

    公开(公告)日：2008-06-11

    申请号：EP07021294.9

    申请日：1998-05-19

    申请人： NYMOX CORPORATION

    发明人： Averback, Paul ,  Ghanbari, Hossein ,  Beheshti, Iraj ,  Morse, David

    IPC分类号： C07C43/164 ,  A61K31/08 ,  C07C43/174 ,  C07C217/10 ,  C07D211/90 ,  C07D295/02 ,  C07D295/08 ,  C07D473/04 ,  A61K31/495 ,  A61K31/44 ,  A61K31/52

    CPC分类号： C07D295/03 ,  C07C43/164 ,  C07C43/1745 ,  C07C211/28 ,  C07C217/10 ,  C07D211/90 ,  C07D295/088 ,  C07D473/04

    摘要： The invention relates to a compound of the following general formula (III):

    wherein:
    R 1 and R 2 each are one or more independent substituents selected from the group consisting of hydrogen, C1-C5 alkyl, C2-C5 alkenyl, C3-C5 cycloalkyl, C1-C5 alkoxy, C2-C5 alkynyl, halogen, C1-C5 haloalkyl, alkylamino, phenyl, nitro and carboxyl;
    R 3 is selected from the group consisting of amino, C1-C5 substituted amino and CH 2 ;
    n and m are independently an integer of from 0-5;

    or a pharmaceutically acceptable salt of such compound;
    a compound of the following general formula (IV):

    wherein:
    R 1 and R 2 each are one or more independent substituents selected from the group consisting of hydrogen, C1-C5 alkyl, C2-C5 alkenyl, C3-C5 cycloalkyl, C1-C5 alkoxy, C2-C5 alkynyl, halogen, C1-C5 haloalkyl, alkylamino, phenyl, nitro and ca rboxyl;
    R 3 and R 4 each are independent and selected from the group consisting of hydrogen and C1-C5 alkyl;
    n is an integer of from 1 to 5;

    or a pharmaceutically acceptable salt of such compound;
    a compound of the following general formula (V):

    wherein:
    R 1 and R 2 each are one or more independent substituents selected from the group consisting of hydrogen, C1-C5 alkyl, C2-C5 alkenyl, C3-C5 cycloalkyl, C1-C5 alkoxy, C2-C5 alkynyl, halogen, C1-C5 haloalkyl, alkylamino, phenyl, nitro and carboxyl;
    R 3 is selected from hydrogen and C1-C5 alkyl;
    R 4 is selected from hydrogen and C1-C5 alkyl;
    n is an integer of from 1 to 5 inclusive;
    or a pharmaceutically acceptable salt of such compound; and
    a compound of the following general formula (VI):

    wherein:
    R 1 and R 2 each are one or more independent substituents selected from the group consisting of hydrogen, C1-C5 alkyl, C2-C5 alkenyl, C3-C5 cycloalkyl, C1-C5 alkoxy, C2-C5 alkynyl, halogen, C1-C5 haloalkyl, alkylamino, phenyl, nitro and carboxyl;
    R3 and R4 each are independent and selected from hydrogen and C1-C5 alkyl;
    n is an integer of from 1 to 5 inclusive;
    or a pharmaceutically acceptable salt of such compound.
    Also compositions comprising the compounds III-VI as well as uses of said compounds.

    摘要翻译： 本发明涉及以下通式（III）的化合物：其中：R 1和R 2各自为选自氢，C 1 -C 5烷基，C 2 -C 5烯基，C 3 -C 5中的一个或多个独立取代基 环烷基，C 1 -C 5烷氧基，C 2 -C 5炔基，卤素，C 1 -C 5卤代烷基，烷基氨基，苯基，硝基和羧基; R 3选自氨基，C 1 -C 5取代的氨基和CH 2; n和m独立地为0-5的整数; 或该化合物的药学上可接受的盐; 下列通式（IV）的化合物：其中：R 1和R 2各自为一个或多个选自氢，C 1 -C 5烷基，C 2 -C 5烯基，C 3 -C 5环烷基，C 1 -C 5环烷基， C5烷氧基，C2-C5炔基，卤素，C1-C5卤代烷基，烷基氨基，苯基，硝基和羧基; R 3和R 4各自独立地选自氢和C 1 -C 5烷基; n为1〜5的整数， 或该化合物的药学上可接受的盐; 下列通式（V）的化合物：其中：R 1和R 2各自为一个或多个选自氢，C 1 -C 5烷基，C 2 -C 5烯基，C 3 -C 5环烷基，C 1 -C 5环烷基， C5烷氧基，C2-C5炔基，卤素，C1-C5卤代烷基，烷基氨基，苯基，硝基和羧基; R 3选自氢和C 1 -C 5烷基; R 4选自氢和C 1 -C 5烷基; n为1〜5的整数， 或该化合物的药学上可接受的盐; 和下列通式（VI）的化合物：其中：R 1和R 2各自为一个或多个选自氢，C 1 -C 5烷基，C 2 -C 5烯基，C 3 -C 5环烷基，C 1 -C 5环烷基 C 5烷氧基，C 2 -C 5炔基，卤素，C 1 -C 5卤代烷基，烷基氨基，苯基，硝基和羧基; R 3和R 4各自独立地选自氢和C 1 -C 5烷基; n为1〜5的整数， 或该化合物的药学上可接受的盐。 还包含化合物III-VI的组合物以及所述化合物的用途。

    MONOMERES, POLYMERES INCORPORANT LESDITS MONOMERES ET LEUR UTILISATION AU SEIN DE DISPOSITIFS ORGANIQUES ELECTROLUMINESCENTS
    8.
    发明公开
    MONOMERES, POLYMERES INCORPORANT LESDITS MONOMERES ET LEUR UTILISATION AU SEIN DE DISPOSITIFS ORGANIQUES ELECTROLUMINESCENTS 有权
    单体，含聚合物和它们在机电致发光元件

    公开(公告)号：EP1212271A1

    公开(公告)日：2002-06-12

    申请号：EP00962635.9

    申请日：2000-09-14

    申请人： UNIVERSITE JOSEPH FOURIER - Grenoble 1

    发明人： STEPHAN, Olivier ,  ARMAND, Michel ,  VIAL, Jean-Claude

    IPC分类号： C07C43/174 ,  C09K11/06 ,  H01L51/30 ,  C08G61/10

    CPC分类号： H01L51/0039 ,  C07C43/1747 ,  C07C43/2055 ,  C07C43/225 ,  C07C2603/18 ,  C08G61/10 ,  H01L51/0035 ,  H01L51/0038 ,  H01L51/0043 ,  H01L51/5012

    摘要： The invention concerns a monomer of general formula A-(Q-S)p wherein: A = an aromatic or heteroaromatic ring; Q = a carbonaceous or siliceous divalent radical, respectively corresponding to general formulae: (CR1R2)n wherein: R1, R2 = H, alkyl, alkenyl comprising between 1 to 4 carbon atoms and n ranges between 4 and 24; and [O-Si(R1R2)]n wherein R1, R2 = H, alkyl, alkenyl comprising between 1 and 4 carbon atoms and n ranges between 3 and 24; S = a solvating segment consisting of at least an aliphatic chain comprising at least a polar heteroatom. 1≤p≤6. The invention also concerns the polymer (homopolymer or copolymer) incorporating said monomer, and their use in organic electroluminescent devices.

    摘要翻译： 本发明涉及通式A-（Q-S）p worin的单体：A =芳族或杂芳族环; Q =含碳或含硅二价基团，分别对应于一般公式：（CR <1> [R <2>）n其中，R <1>，R <2> = H，烷基，烯基1之间，其包括至4个碳原子 和n 4和24之间的范围; 和[O-的Si（R <1> [R <2>）] n其中R <1>，R <2> = H，烷基，烯基，其包括1和4之间的碳原子和n为3和24之间; S =溶剂化段，其由至少脂族链，其包含至少一个杂原子的极性的。 1 <= p <= 6 本发明因此涉及聚合物（均聚物或共聚物）将所述单体和它们在有机发光器件中使用。