公开(公告)号：EP2114916A2

公开(公告)日：2009-11-11

申请号：EP08708543.7

申请日：2008-02-01

申请人： NeuroSearch A/S

发明人： ERIKSEN, Birgitte, L. ,  SØRENSEN, Ulrik, Svane ,  HOUGAARD, Charlotte ,  TEUBER, Lene ,  PETERS, Dan ,  JOHANSEN, Tina, Holm ,  CHRISTOPHERSEN, Palle

IPC分类号： C07D401/04 ,  C07D405/14 ,  A61K31/4439 ,  A61P11/00

CPC分类号： C07D401/04 ,  C07D405/14

摘要： This invention relates to novel pyridinyl-pyrazole derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.

公开(公告)号：EP1594868B1

公开(公告)日：2009-11-11

申请号：EP04709633.4

申请日：2004-02-10

申请人： NeuroSearch A/S

发明人： PETERS, Dan ,  NIELSEN, Elsebet Ostergaard ,  OLSEN, Gunnar M. ,  SCHEEL-KRÜGER, Jurgen

IPC分类号： C07D451/02 ,  A61K31/46 ,  A61P25/00

CPC分类号： C07D451/02

摘要： This invention relates to novel 8-aza-bicyclop[3.2. 1 ]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

公开(公告)号：EP2094655A1

公开(公告)日：2009-09-02

申请号：EP07857650.1

申请日：2007-12-17

申请人： NeuroSearch A/S

发明人： NARDI, Antonio ,  DEMNITZ, Joachim ,  GRUNNET, Morten ,  CHRISTOPHERSEN, Palle ,  JONES, David Spencer ,  NIELSEN, Elsebet Østergaard ,  STRØBÆK, Dorte ,  MADSEN, Lars Siim

IPC分类号： C07C335/18 ,  C07D257/04 ,  A61K31/17 ,  A61P15/12

CPC分类号： C07D257/04 ,  A61K31/17 ,  A61K31/41 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/53 ,  C07C335/18

摘要： The invention relates to novel biphenyl thio-urea derivatives of Formula (I), wherein A represents hydroxy or tetrazolyl; R1 represents halo, hydroxy or phenyl, which phenyl may optionally be substituted with halo; and R2 and R3, independent of each other, represent halo, trifluoromethyl, nitro and/or phenyl, that are found to be potent modulators of ion channels and, as such, they are valuable candidates for the treatment of disease or disorders as diverse as those which are responsive to modulation of ion channels.

公开(公告)号：EP1877052B1

公开(公告)日：2009-07-22

申请号：EP06725630.5

申请日：2006-04-07

申请人： NeuroSearch A/S

发明人： LARSEN, Janus S. ,  TEUBER, Lene ,  AHRING, Philip K. ,  NIELSEN, Elsebet Østergaard ,  MIRZA, Naheed

IPC分类号： A61K31/4184 ,  C07D401/10 ,  C07D403/10 ,  C07D417/10 ,  C07D417/14 ,  A61P25/00

CPC分类号： C07D403/10 ,  C07D401/10 ,  C07D417/10

摘要： This invention relates to novel benzimidazole derivatives of formula (I), pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABA receptor complex, and in particular for combating anxiety and related diseases.

公开(公告)号：EP2049538A1

公开(公告)日：2009-04-22

申请号：EP07729593.9

申请日：2007-05-29

申请人： NeuroSearch A/S

发明人： PETERS, Dan ,  OLSEN, Gunnar, M. ,  NIELSEN, Elsebet, Østergaard ,  TIMMERMANN, Daniel, B. ,  LOECHEL, Steven, Charles

IPC分类号： C07D471/08 ,  A61K31/551 ,  A61P25/00

CPC分类号： C07D471/08

摘要： This invention relates to a novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its use in the manufacture of pharmaceutical compositions. The compound of the invention is found to be a cholinergic ligand at the nicotinic acetylcholine receptors. Due to its pharmacological profile the compound of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

公开(公告)号：EP2029594A1

公开(公告)日：2009-03-04

申请号：EP07729313.2

申请日：2007-05-21

申请人： NEUROSEARCH A/S

发明人： PETERS, Dan ,  OLSEN, Gunnar, M. ,  NIELSEN, Elsebet, Østergaard ,  TIMMERMANN, Daniel, B. ,  LOECHEL, Steven, Charles ,  CHRISTENSEN, Jeppe, Kejser ,  DYHRING, Tino

IPC分类号： C07D471/08 ,  A61K31/55 ,  A61P25/00

CPC分类号： C07D471/08

摘要： This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonane derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

公开(公告)号：EP2027122A1

公开(公告)日：2009-02-25

申请号：EP07729315.7

申请日：2007-05-21

申请人： NeuroSearch A/S

发明人： PETERS, Dan ,  OLSEN, Gunnar M. ,  NIELSEN, Elsebet Østergaard ,  TIMMERMANN, Daniel, B. ,  LOECHEL, Steven, Charles ,  CHRISTENSEN, Jeppe, Kejser ,  DYHRING, Tino

IPC分类号： C07D471/08 ,  A61K31/551 ,  A61P25/00 ,  A61P25/28

CPC分类号： C07D471/08

摘要： This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonane derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

公开(公告)号：EP1819709B1

公开(公告)日：2009-02-11

申请号：EP05817438.4

申请日：2005-11-29

申请人： NEUROSEARCH A/S

发明人： PETERS, Dan ,  TIMMERMANN, Daniel, B. ,  OLSEN, Gunnar, M. ,  NIELSEN, Elsebet, Østergaard ,  JØRGENSEN, Tino, Dyhring

IPC分类号： C07D487/08 ,  A61K31/4995 ,  A61P25/00

CPC分类号： C07D487/08

摘要： This invention relates to novel diazabicyclic aryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

公开(公告)号：EP1663192B1

公开(公告)日：2008-12-03

申请号：EP04766708.4

申请日：2004-09-06

申请人： NeuroSearch A/S

发明人： OLESEN, Soeren, Peter ,  GRUNNET, Morten ,  CHRISTOPHERSEN, Palle ,  STROBAEK, Dorte ,  DEMNITZ, Joachim ,  HANSEN, Rie, S.

IPC分类号： A61K31/17 ,  A61K31/41 ,  A61K31/00 ,  A61P9/06 ,  A61P9/10

CPC分类号： A61K31/00 ,  A61K31/17 ,  A61K31/41

摘要： This invention relates to the use of ERG channel openers for the treatment of cardiac arrhythmias, and to the use of specific compounds for such treatment. In a separate aspect the invention provides novel compounds useful as ERG channel openers.

公开(公告)号：EP1987033A1

公开(公告)日：2008-11-05

申请号：EP07712214.1

申请日：2007-02-13

申请人： NEUROSEARCH A/S

发明人： PETERS, Dan ,  TIMMERMANN, Daniel, B. ,  OLSEN, Gunnar, M. ,  NIELSEN, Elsebet, Østergaard ,  CHRISTENSEN, Jeppe, Kejser ,  DYHRING, Tino

IPC分类号： C07D471/08 ,  A61K31/4995 ,  A61P25/28

CPC分类号： C07D471/08

摘要： This invention relates to novel diaza-bicyclo-alkane derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.