公开(公告)号：EP1267908A1

公开(公告)日：2003-01-02

申请号：EP01919363.0

申请日：2001-03-01

申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A.

发明人： FRUCHART, Jean-Charles,Institut Pasteur de Lille ,  MONTEYNE, Philippe,GlaxoSmithKline ,  PALMANTIER, Remi,GlaxoSmithKline ,  VAN MECHELEN, Marcelle, Paulette,GlaxoSmithKline

IPC分类号： A61K38/17

CPC分类号： A61K39/0012 ,  A61K2039/55577 ,  A61K2039/6081

摘要： Novel vaccine therapies, and prophylactic treatments of atherosclerotic diseases involving use of immugones comprising apolipoproteins, or fragments thereof, having at least one of the following activities: (a) the inhibition of the binding of Apolipoprotein B to its receptor, and, or, (b) the inhibition of lipoprotein lipase. A preferred example of one such apolipoprotein is Apolipoprotein C-III (ApoCIII). The vaccines of the present invention, comprising said immunogens, prevent atheroslerosis plaque formation, thereby reducing coronary or cerebrovascular disease. Artherosclerosis is also treated by selectively inhibiting the activity of specific apolipoproteins e.g. ApoCIII in a human, comprising administering an agent which results in the selective inhibition of the apolipoprotein activity to a human. Atherosclerosis is also treated by active or passive vaccination, by administering an antibody that is capable of binding to a apoliprotein e.g. ApoCIII that has at least one of the following activities: (a) the inhibition of the binding of Apolipoprotein B to its receptor, and, or, (b) the inhibition of lipoprotein lipase.

公开(公告)号：EP1265915A2

公开(公告)日：2002-12-18

申请号：EP01929345.5

申请日：2001-02-16

申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A.

发明人： CABEZON-SILVA, T.E.V.,SmithKline Beecham Bio. SA ,  CASSART, J.P.,SmithKline Beecham Biologicals SA ,  COCHE, Thierry,SmithKline Beecham Biologicals SA ,  GAULIS, S.R.J.T.,SmithKline Beecham Bio. SA ,  VINALS Y DE BASSOLS, C.,SmithKline Beecham Bio.SA

IPC分类号： C07K14/00

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  C07K14/82

摘要： CASB7439 polypeptides and polynucleotides, immunogenic compositions comprising them and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing CASB7439 polypeptides and polynucleotides in diagnostics, and vaccines for prophylactic and therapeutic treatment of cancers, particularly colorectal cancers, autoimmune diseases, and related conditions.

摘要翻译： 公开了CASB7439多肽和多核苷酸，包含它们的免疫原性组合物和通过重组技术生产这些多肽的方法。 还公开了在诊断中利用CASB7439多肽和多核苷酸的方法，以及用于预防和治疗癌症，特别是结肠直肠癌，自身免疫疾病和相关病症的疫苗。

公开(公告)号：EP1212426A1

公开(公告)日：2002-06-12

申请号：EP00964177.0

申请日：2000-09-14

申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A.

发明人： THONNARD, Joelle

IPC分类号： C12N15/31 ,  C12N15/62 ,  C07K14/21 ,  C07K16/12 ,  A61K31/711 ,  A61K39/02 ,  A61K39/40

CPC分类号： C07K14/212 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/53 ,  C07K16/1214 ,  C07K2319/00

摘要： The invention provides BASB109 polypeptides and polynucleotides encoding BASB109 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.

公开(公告)号：EP1206548A1

公开(公告)日：2002-05-22

申请号：EP00956353.7

申请日：2000-07-31

申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A.

发明人： THONNARD, Joelle,SmithKline Beecham Bio. s. a.

IPC分类号： C12N15/31 ,  C07K14/21 ,  C07K16/12 ,  A61K39/02 ,  A61K39/395 ,  A61K48/00 ,  G01N33/569

CPC分类号： C07K14/212 ,  A61K39/00 ,  A61K48/00

摘要： The invention provides BASB118 polypeptides and polynucleotides encoding BASB118 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.

公开(公告)号：EP1196586A1

公开(公告)日：2002-04-17

申请号：EP00942127.2

申请日：2000-06-23

申请人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.),formerly SMITHKLINE BIOLOGICALS (S.A.)

发明人： THONNARD, JoelleSmithKline Beecham Biologicals SA

IPC分类号： C12N15/31 ,  C07K14/21 ,  A61K39/02 ,  A61K39/395 ,  A61K48/00 ,  G01N33/569 ,  C07K16/12

CPC分类号： C07K14/212 ,  A61K39/00 ,  A61K48/00

摘要： The invention provides BASB111 polypeptides and polynucleotides encoding BASB111 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.

公开(公告)号：EP1187629A2

公开(公告)日：2002-03-20

申请号：EP00920647.5

申请日：2000-04-04

申请人： SmithKline Beecham Biologicals s.a.

发明人： FRIEDE, Martin,SmithKline Beecham Biologicals SA ,  GARCON, Nathalie ,  HERMAND, Philippe

IPC分类号： A61K39/00 ,  A61K39/39 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61P37/08 ,  A61P25/28

CPC分类号： A61K39/39 ,  A61K39/0011 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/55577 ,  A61K2039/55583 ,  A61K2039/6068 ,  Y02A50/386 ,  Y02A50/412

摘要： The present invention relates to adjuvant compositions which are suitable to be used in vaccines. In particular, the adjuvant compositions of the present invention comprises a saponin and an immunostimulatory oligonucleotide, optionally with a carrier. Also provided by the present invention are vaccines comprising the adjuvants of the present invention and an antigen. Further provided are methods of manufacture of the adjuvants and vaccines of the present invention and their use as medicaments. Methods of treating an individual susceptible to or suffering from a disease by the administration of the vaccines of the present invention are also provided.

公开(公告)号：EP1171159A2

公开(公告)日：2002-01-16

申请号：EP00940231.4

申请日：2000-04-17

申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A.

发明人： DESCHAMPS, Marguerite ,  LAFERRIERE, Craig, Antony, Joseph

IPC分类号： A61K39/295 ,  A61P31/04 ,  A61P31/14

CPC分类号： A61K39/092 ,  A61K39/102 ,  A61K39/12 ,  A61K39/155 ,  A61K39/385 ,  A61K2039/5254 ,  A61K2039/543 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/57 ,  A61K2039/6068 ,  A61K2039/70 ,  C12N2501/056 ,  C12N2760/18534

摘要： This invention relates to a vaccine composition comprising: (a) one or more Streptococcus pneumoniae polysaccharides either conjugated to a protein or peptide, or non-conjugated; and (b) an RSV antigen in conjunction with an adjuvant which is a preferential stimulator of a Th1 type immune response. The combination vaccines provided by the invention are useful particularly for children and the elderly.

公开(公告)号：EP1163265A1

公开(公告)日：2001-12-19

申请号：EP00907603.5

申请日：2000-02-23

申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A.

发明人： RUELLE, Jean-Louis

IPC分类号： C07K14/21 ,  C12N15/00 ,  C07K16/12

CPC分类号： C12R1/38 ,  A61K2039/53

摘要： The invention provides BASB081 polypeptides from moraxella catarrhalis and polynucleotides encoding BASB081 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.

公开(公告)号：EP1162993A2

公开(公告)日：2001-12-19

申请号：EP00907633.2

申请日：2000-02-28

申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A.

发明人： VINALS y de BASSOLS, Carlota

IPC分类号： A61K38/17 ,  A61K39/395 ,  C07K14/705 ,  A61P35/00 ,  A61K39/00 ,  A61K48/00 ,  C07K16/28 ,  G01N33/68 ,  C12Q1/68 ,  C12N15/12

CPC分类号： A61K39/0011 ,  A61K48/00 ,  C07K14/705

摘要： Use of CASB616 polypeptides and polynucleotides in diagnostics, and vaccines for prophylactic and therapeutic treatment of cancers, particularly colon cancers, autoimmune diseases, and related conditions.

公开(公告)号：EP1151105A1

公开(公告)日：2001-11-07

申请号：EP00903670.8

申请日：2000-02-04

申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A.

发明人： THONNARD, JoelleSmithKline Beecham Bio. S.A.

IPC分类号： C12N15/31 ,  C07K14/22 ,  C12N1/11 ,  A61K39/095 ,  A61K39/40 ,  C07K16/12 ,  G01N33/50 ,  C12N15/62

CPC分类号： C07K14/22 ,  A61K38/00 ,  C07K2319/00

摘要： The invention provides BASB064 polypeptides and polynucleotides encoding BASB064 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.