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136 条记录 (耗时 0.007 秒)

    NON-CRYSTALLINE MATERIALS HAVING COMPLETE PHOTONIC, ELECTRONIC, OR PHONONIC BAND GAPS
    104.
    发明公开
    NON-CRYSTALLINE MATERIALS HAVING COMPLETE PHOTONIC, ELECTRONIC, OR PHONONIC BAND GAPS 审中-公开
    NICHT KRISTALLINE MATERIALIEN MITVOLLSTÄNDIGPHOTONISCHEN，ELEKTRONISCHEN ODER PHONONISCHENBANDLÜCKEN

    公开(公告)号：EP2445986A4

    公开(公告)日：2017-09-13

    申请号：EP10797577

    申请日：2010-06-22

    申请人： UNIV PRINCETON

    发明人： STEINHARDT PAUL J ,  TORQUATO SALVATORE ,  FLORESCU MARIAN

    IPC分类号： G02B5/00 ,  C09K11/00 ,  G02B1/00 ,  G02B6/125

    CPC分类号： G02B1/005 ,  B82Y20/00 ,  G01K17/00 ,  G01L1/24 ,  G01N21/17 ,  G02B5/3025 ,  G02B6/1225 ,  G02B6/125 ,  G02B27/0012 ,  H01L33/0058 ,  H01L33/0095 ,  H01L33/16 ,  Y10T29/49993

    摘要： The invention provides an article of manufacture, and methods of designing and making the article. The article permits or prohibits waves of energy, especially photonic/electromagnetic energy, to propagate through it, depending on the energy band gaps built into it. The structure of the article may be reduced to a pattern of points having a hyperuniform distribution. The point-pattern may exhibit a crystalline symmetry, a quasicrystalline symmetry or may be aperiodic. In some embodiments, the point pattern exhibits no long-range order. Preferably, the point-pattern is isotropic. In all embodiments, the article has a complete, TE- and TM-optimized band-gap. The extraordinary transmission phenomena found in the disordered hyperuniform photonic structures of the invention find use in optical micro-circuitry (all-optical, electronic or thermal switching of the transmission), near-field optical probing, thermophotovoltaics, and energy-efficient incandescent sources.

    摘要翻译： 本发明提供了一种制造物品，以及设计和制造该物品的方法。 该文章允许或禁止能量波，特别是光子/电磁能，通过它传播，取决于内置的能带隙。 物品的结构可以被缩小为具有超均匀分布的点的图案。 点图案可以表现出晶体对称性，准晶体对称性或者可以是非周期性的。 在一些实施例中，点图案不显示长程有序。 优选地，点图案是各向同性的。 在所有实施例中，该文章具有完整的TE和TM优化的带隙。 在本发明的无序超均匀光子结构中发现的非凡透射现象可用于光学微电路（传输的全光，电子或热切换），近场光探测，热光电伏特和高能效白炽光源。

    SPLIT INTEINS, CONJUGATES AND USES THEREOF
    107.
    发明公开
    SPLIT INTEINS, CONJUGATES AND USES THEREOF 审中-公开
    GETEILTE INTEINE，KONJUGATE DAVON UND VERWENDUNGEN DAVON

    公开(公告)号：EP2877490A4

    公开(公告)日：2016-07-06

    申请号：EP13809861

    申请日：2013-06-24

    申请人： UNIV PRINCETON

    发明人： MUIR TOM W ,  VILA-PERELLO MIQUEL ,  LIU ZHIHUA ,  SHAH NEEL H

    IPC分类号： C07K16/18

    CPC分类号： C07K16/18 ,  C07K14/195 ,  C07K2319/50 ,  C07K2319/92 ,  C12N9/93 ,  C12N15/62 ,  C12P21/02 ,  C12P21/06

    摘要： Disclosed herein are split inteins, fused proteins of split inteins, and methods of using split inteins to efficiently purify and modify proteins of interest. Thus, provided herein are fusion proteins of a polypeptide and a split intein N-fragment, or variant thereof, as described below in greater detail. Also provided are complexes of the fusion protein and a split intein C-fragment or variant thereof as described in detail below. The complex of the fusion protein and C-fragment or variant thereof can be via a covalent interaction between the fusion protein and C-fragment or variant or via a noncovalent interaction (e.g., ionic, H-bonding, and/or van der Waals interaction). Further provided herein are split intein C-fragments or variants thereof.

    摘要翻译： 本文公开了分裂的内含肽，裂解内含肽的融合蛋白，以及使用裂解内含肽来有效纯化和修饰目的蛋白的方法。 因此，本文提供了多肽和分裂内蛋白N-片段或其变体的融合蛋白，如下文更详细描述的。 还提供了融合蛋白的复合物和分裂的内含肽C片段或其变体，如下面详细描述的。 融合蛋白和C-片段或其变体的复合体可以通过融合蛋白和C片段或变体之间的共价相互作用或通过非共价相互作用（例如，离子，H键合和/或范德华相互作用 ）。 本文进一步提供分裂的内含肽C-片段或其变体。

    MULTISCALE SPECTRAL NANOSCOPY
    108.
    发明公开
    MULTISCALE SPECTRAL NANOSCOPY 审中-公开
    MULTISKALARE SPEKTRALE NANOSKOPIE

    公开(公告)号：EP2874700A4

    公开(公告)日：2016-04-13

    申请号：EP13820283

    申请日：2013-07-18

    申请人： UNIV PRINCETON

    发明人： YANG HAW ,  WELSHER KEVIN

    IPC分类号： A61N5/00 ,  G01N15/14 ,  G01N21/64 ,  G02B21/00

    CPC分类号： G01N21/6458 ,  G01N15/1475 ,  G01Q90/00 ,  G02B21/0024

    摘要： A system and method for non-invasively tracking a particle in a sample is disclosed. The system includes a 2-photon or confocal laser scanning microscope (LSM) and a particle-holding device coupled to a stage with X-Y and Z position control. The system also includes a tracking module having a tracking excitation laser, X-Y and Z radiation-gathering components configured to detect deviations of the particle in an X-Y and Z directions. The system also includes a processor coupled to the X-Y and Z radiation gathering components, generate control signals configured to drive the stage X-Y and Z position controls to track the movement of the particle. The system may also include a synchronization module configured to generate LSM pixels stamped with stage position and a processing module configured to generate a 3D image showing the 3D trajectory of a particle using the LSM pixels stamped with stage position.

    ORGANO-CASCADE CATALYSIS: ONE-POT PRODUCTION OF CHEMICAL LIBRARIES
    109.
    发明公开
    ORGANO-CASCADE CATALYSIS: ONE-POT PRODUCTION OF CHEMICAL LIBRARIES 审中-公开
    ORGANO CASSETTE CATALYSTS：STERLING CHEMICAL LIBRARIES

    公开(公告)号：EP2179080A4

    公开(公告)日：2015-04-15

    申请号：EP08782114

    申请日：2008-07-21

    申请人： UNIV PRINCETON

    发明人： MACMILLAN DAVID

    IPC分类号： C40B50/08 ,  C40B40/04

    CPC分类号： C07C45/61 ,  C40B40/04 ,  C40B50/08

    摘要： A method for production of a chemical library is provided, where the method involves: reacting, in a single vessel, a) a plurality, x, of aldehydes and/or ketones; and b) either (i) a plurality, y, of nucleophiles, (ii) a plurality, z, of electrophiles or both (i) and (ii); in the presence of c) a cascade catalyst capable of catalyzing reaction between said plurality of aldehydes and/or ketones and said plurality of nucleophiles, said plurality of electrophiles or both; to obtain a mixture of x-y &bgr;-nucleophile substituted aldehydes and/or ketones, xz α-electrophile substituted aldehydes and/or ketones or xyz &bgr;-nucleophile substituted, α-electrophile substituted aldehydes and/or ketones; and the chemical libraries thus produced.

    摘要翻译： 提供了一种生产化学文库的方法，其中所述方法包括：在单个容器中使a）多个x的醛和/或酮酮反应; 和b）（i）多个y，亲核体，（ii）多个z，亲电子体，或（i）和（ii）两者; 在c）能够催化所述多种醛和/或酮和所述多种亲核试剂，所述多种亲电子体或两者之间的反应的级联催化剂的存在下， 以获得x-y和bgr-亲核体取代的醛和/或酮的混合物，xzα-亲电取代的醛和/或酮或xyz和bgr-亲核体取代的α-亲电试剂取代的醛和/或酮; 和这样生产的化学文库。