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316 条记录 (耗时 0.016 秒)

    ION CHANNELS, IN PARTICULAR VANILLOID RECEPTOR-LIKE (VR-L) RECEPTOR
    104.
    发明公开
    ION CHANNELS, IN PARTICULAR VANILLOID RECEPTOR-LIKE (VR-L) RECEPTOR 审中-公开
    离子通道，特别是在香草素受体样受体

    公开(公告)号：EP1117782A2

    公开(公告)日：2001-07-25

    申请号：EP99949193.9

    申请日：1999-10-08

    申请人： UNIVERSITY COLLEGE LONDON

    发明人： GARCIA, Reynaldo ,  WOOD, John NicholasUni. College London ,  ENGLAND, StevenPfizer Limited

    IPC分类号： C12N15/12 ,  C07K14/705 ,  C12Q1/68 ,  A01K67/00 ,  A61K48/00 ,  C12N15/11 ,  C07H21/00 ,  G01N33/50 ,  C07K16/28

    CPC分类号： C07K14/705 ,  A01K2217/05 ,  A61K48/00

    摘要： The invention provides isolated non-selective cation channel proteins which are (a) activatable by noxious heat; (b) obtainable from human T lymphocytes; (c) not capsaicin sensitive, particularly the VR-L protein (Seq ID No. 2), plus or variants (e.g. homologues or fragments) thereof. Also provided are nucleic acids encoding these (e.g. Seq ID No. 1), or which have utility in probing, amplifying or down-regulating these. Methods of providing the proteins and nucleic acids are disclosed, as are vectors, host cells, and organisms utilising them, and antibodies. Also disclosed are methods of influencing the electrophysiological and/or pharmacological properties of a cell (e.g. by way of therapy) based on manipulation of the proteins or nucleic acids, and methods for screening for substances having ion-channel modulating activity (which may be potential analgesics or other compounds which affect nociception, immunomodulatory agents or neuromodulatory agents).

    IMPROVEMENTS IN OR RELATING TO HELICALLY WOUND REINFORCING COMPONENTS FOR FLEXIBLE TUBULAR CONDUITS
    105.
    发明公开
    IMPROVEMENTS IN OR RELATING TO HELICALLY WOUND REINFORCING COMPONENTS FOR FLEXIBLE TUBULAR CONDUITS 审中-公开
    螺旋缠绕加强件FOR柔性管状PIPES

    公开(公告)号：EP1073857A1

    公开(公告)日：2001-02-07

    申请号：EP99919416.0

    申请日：1999-04-30

    申请人： UNIVERSITY COLLEGE LONDON

    发明人： WITZ, Joel Aaron ,  BURKE, Raymond Nicholas

    IPC分类号： F16L11/16 ,  F16L11/08

    CPC分类号： F16L11/16 ,  E21B17/015 ,  F16L11/083

    摘要： This invention relates to flexible tubular conduits or pipes particularly in situations where the conduits need to withstand relatively high pressures. In such cases, the conduits are reinforced by helically wound armor which is compliant in flexure, and profiled to allow each subsequent turn to interlock with the previous turn. The invention provides a locking mechanism (8, 9) located in the axial direction of the tubular conduit comprising one or more projections (8) on one or both radial sides and a corresponding number of sockets (9) on the opposing radial sides, such that the projections (8) of one turn of the winding (10) engaging in the sockets (9) of the next turn of the winding (10), each projection (8) having an enlarged head portion (11) connected to a body by a narrow neck portion (12), and each socket having a corresponding shape to hold the projection captive in the socket, the sockets (8) and projections (9) having dimensions to allow a limited relative rotation between the adjacent turns of the winding and to resist separation, closing, and relative radial movement of the respective turns.

    DETERMINATION OF THE RATIO OF ABSORPTION COEFFICIENTS AT DIFFERENT WAVELENGTHS IN A SCATTERING MEDIUM
    107.
    发明公开
    DETERMINATION OF THE RATIO OF ABSORPTION COEFFICIENTS AT DIFFERENT WAVELENGTHS IN A SCATTERING MEDIUM 失效
    散射介质中不同波长吸收系数的比值确定

    公开(公告)号：EP0956495A1

    公开(公告)日：1999-11-17

    申请号：EP98902110.0

    申请日：1998-01-30

    申请人： UNIVERSITY COLLEGE LONDON

    发明人： KOHL, Matthias ,  WATSON, Russell ,  COPE, Mark

    IPC分类号： G01N21 ,  A61B5

    CPC分类号： G01N21/314

    摘要： A method of determining the ratio of the absolute absorption coefficients νa(μ2) and νa(μ1) of a light scattering medium at two different wavelengths comprising: a) passing light (as herein defined) through the medium; b) measuring a characteristic X of the light at two wavelengths μ1 and μ2 which is affected by the absorption coefficient during its passage through the medium; c) effecting changes Δνa(μ1) and Δνa(μ2) in the absorption coefficients at the two wavelengths; d) repeating step (b); e) determining the ratio of the absolute absorption coefficients νa(μ1) and νa(μ2) at said two wavelengths from the said changes therein Δνa(μ1) and Δνa(μ2) or from quantities representative thereof, from the characteristic X, and from the ratio of transport scattering coefficients of the medium νs'(μ1) and νs'(μ2) at the two wavelengths.

    摘要翻译： 一种确定两种不同波长的光散射介质的绝对吸收系数νa（μ2）和νa（μ1）之比的方法，包括：a）使光（如本文所定义的）通过介质; b）测量在通过介质期间受吸收系数影响的两个波长μ1和μ2处的光的特性X; c）在两个波​​长处的吸收系数中改变Δνa（μ1）和Δνa（μ2）; d）重复步骤（b）; e）根据其中的所述变化Δνa（μ1）和Δνa（μ2）或由其代表量确定所述两个波长处的绝对吸收系数νa（μ1）和νa（μ2）的比率，从特性X和 在两个波长处介质νs'（μ1）和νs'（μ2）的传输散射系数的比率。